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[Detection of TNF-alpha and NCF in the serum and BALF of patients with sarcoidosis and evaluate their clinical significance].
Zhonghua Jie He He Hu Xi Za Zhi. 1999 Jan; 22(1):37-9.ZJ

Abstract

OBJECTIVE

To evaluate the role of cytokines released by the inflammatory cells and immunocytes from patients in pathogenesis of developing sarcoidosis.

METHODS

With well- microchemotaxis and allergy immunology, the level of tumor necrosis factor-alpha (TNF-alpha) and neutrophil chemotactic factor (NCF) was measured in the serum and BALF of 11 sarcoidosis and 7 IPF and 8 normal subjects (non-smokers).

RESULTS

The levels of TNFalpha (11.9 +/- 3.2, 11.7 +/- 3.0 ng x L(-1)) and NCF (191 +/- 51, 203 +/- 44 cell x 10HP(-1)) of BALF in the patients with sarcoidosis and IPF were significantly higher than these in control group (P < 0.01) and were higher than those in serum. The level of TNF-alpha in the BALF of patients with sarcoidosis was positively correlated with the percentage of lymphocytes (r = 0.73, P < 0.01). The activity of NCF in the BALF of patients with IPF was positively correlated with the percentage of neutrophils (r = 0.89, P < 0.01).

CONCLUSIONS

It indicated that TNF-alpha and NCF might play an important role in the pathogenetic process of the sarcoidosis and IPF, and can act as the marker of activity of these diseases.

Authors+Show Affiliations

Respiration Disease Institute of China Medical University, Shenyang 110001.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11812354

Citation

Li, Z, et al. "[Detection of TNF-alpha and NCF in the Serum and BALF of Patients With Sarcoidosis and Evaluate Their Clinical Significance]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 22, no. 1, 1999, pp. 37-9.
Li Z, Chen W, Hou X, et al. [Detection of TNF-alpha and NCF in the serum and BALF of patients with sarcoidosis and evaluate their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1999;22(1):37-9.
Li, Z., Chen, W., Hou, X., & Yu, R. (1999). [Detection of TNF-alpha and NCF in the serum and BALF of patients with sarcoidosis and evaluate their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 22(1), 37-9.
Li Z, et al. [Detection of TNF-alpha and NCF in the Serum and BALF of Patients With Sarcoidosis and Evaluate Their Clinical Significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1999;22(1):37-9. PubMed PMID: 11812354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Detection of TNF-alpha and NCF in the serum and BALF of patients with sarcoidosis and evaluate their clinical significance]. AU - Li,Z, AU - Chen,W, AU - Hou,X, AU - Yu,R, PY - 2002/1/29/pubmed PY - 2003/6/24/medline PY - 2002/1/29/entrez SP - 37 EP - 9 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 22 IS - 1 N2 - OBJECTIVE: To evaluate the role of cytokines released by the inflammatory cells and immunocytes from patients in pathogenesis of developing sarcoidosis. METHODS: With well- microchemotaxis and allergy immunology, the level of tumor necrosis factor-alpha (TNF-alpha) and neutrophil chemotactic factor (NCF) was measured in the serum and BALF of 11 sarcoidosis and 7 IPF and 8 normal subjects (non-smokers). RESULTS: The levels of TNFalpha (11.9 +/- 3.2, 11.7 +/- 3.0 ng x L(-1)) and NCF (191 +/- 51, 203 +/- 44 cell x 10HP(-1)) of BALF in the patients with sarcoidosis and IPF were significantly higher than these in control group (P < 0.01) and were higher than those in serum. The level of TNF-alpha in the BALF of patients with sarcoidosis was positively correlated with the percentage of lymphocytes (r = 0.73, P < 0.01). The activity of NCF in the BALF of patients with IPF was positively correlated with the percentage of neutrophils (r = 0.89, P < 0.01). CONCLUSIONS: It indicated that TNF-alpha and NCF might play an important role in the pathogenetic process of the sarcoidosis and IPF, and can act as the marker of activity of these diseases. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11812354/[Detection_of_TNF_alpha_and_NCF_in_the_serum_and_BALF_of_patients_with_sarcoidosis_and_evaluate_their_clinical_significance]_ L2 - http://www.diseaseinfosearch.org/result/6412 DB - PRIME DP - Unbound Medicine ER -