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Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats.
Pharmacol Biochem Behav. 2002 Jan-Feb; 71(1-2):245-9.PB

Abstract

Overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role. Thus, intervention by antioxidants can be a potential beneficial approach in the treatment of epilepsy. The present study was undertaken to see the effect of trans-resveratrol, a potent antioxidant, against kainic acid-induced seizures, and effect on markers of oxidative stress in brain. Kainic acid, 10 mg/kg ip, induced long-lasting seizures and associated symptoms. The brain level of malondialdehyde (MDA) was found to be significantly raised after kainic acid administration (295 +/- 18 nmol/g wet tissue) as compared to control (195 +/- 26 nmol/g wet tissue). Pretreatment (5 min) of single dose of trans-resveratrol (40 mg/kg i.p.) could not inhibit the convulsions though the latency was significantly increased. When multiple doses of trans-resveratrol were injected in two-dose schedules in different animals (20 and 40 mg/kg ip, 5 min prior and repeated 30 and 90 min after kainic acid), there was significant reduction in incidence of convulsions in both treatment schedules. The brain MDA levels were found to be significantly attenuated in the trans-resveratrol-treated groups (multiple doses of 20 and 40 mg/kg) as compared to the kainic acid alone. However, the glutathione level in control, kainic acid- and trans-resveratrol-treated animals were not significantly different. The protective effect of trans-resveratrol against kainic acid-induced convulsions and the attenuation of raised MDA level suggest the potential use of antioxidants at least as adjunct therapy in epilepsy.

Authors+Show Affiliations

Department of Pharmacology, Neuropharmacology Laboratory, All India Institute of Medical Sciences, New Delhi 110029, India. ykg@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11812529

Citation

Gupta, Y K., et al. "Protective Effect of Trans-resveratrol Against Kainic Acid-induced Seizures and Oxidative Stress in Rats." Pharmacology, Biochemistry, and Behavior, vol. 71, no. 1-2, 2002, pp. 245-9.
Gupta YK, Briyal S, Chaudhary G. Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats. Pharmacol Biochem Behav. 2002;71(1-2):245-9.
Gupta, Y. K., Briyal, S., & Chaudhary, G. (2002). Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats. Pharmacology, Biochemistry, and Behavior, 71(1-2), 245-9.
Gupta YK, Briyal S, Chaudhary G. Protective Effect of Trans-resveratrol Against Kainic Acid-induced Seizures and Oxidative Stress in Rats. Pharmacol Biochem Behav. 2002 Jan-Feb;71(1-2):245-9. PubMed PMID: 11812529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats. AU - Gupta,Y K, AU - Briyal,Seema, AU - Chaudhary,Geeta, PY - 2002/1/29/pubmed PY - 2002/4/6/medline PY - 2002/1/29/entrez SP - 245 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 71 IS - 1-2 N2 - Overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role. Thus, intervention by antioxidants can be a potential beneficial approach in the treatment of epilepsy. The present study was undertaken to see the effect of trans-resveratrol, a potent antioxidant, against kainic acid-induced seizures, and effect on markers of oxidative stress in brain. Kainic acid, 10 mg/kg ip, induced long-lasting seizures and associated symptoms. The brain level of malondialdehyde (MDA) was found to be significantly raised after kainic acid administration (295 +/- 18 nmol/g wet tissue) as compared to control (195 +/- 26 nmol/g wet tissue). Pretreatment (5 min) of single dose of trans-resveratrol (40 mg/kg i.p.) could not inhibit the convulsions though the latency was significantly increased. When multiple doses of trans-resveratrol were injected in two-dose schedules in different animals (20 and 40 mg/kg ip, 5 min prior and repeated 30 and 90 min after kainic acid), there was significant reduction in incidence of convulsions in both treatment schedules. The brain MDA levels were found to be significantly attenuated in the trans-resveratrol-treated groups (multiple doses of 20 and 40 mg/kg) as compared to the kainic acid alone. However, the glutathione level in control, kainic acid- and trans-resveratrol-treated animals were not significantly different. The protective effect of trans-resveratrol against kainic acid-induced convulsions and the attenuation of raised MDA level suggest the potential use of antioxidants at least as adjunct therapy in epilepsy. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/11812529/Protective_effect_of_trans_resveratrol_against_kainic_acid_induced_seizures_and_oxidative_stress_in_rats_ DB - PRIME DP - Unbound Medicine ER -