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Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer Prevention Study II cohort.

Abstract

Supplementation with antioxidant vitamins has been associated with decreased risk of stomach cancer or regression of precancerous lesions in high-risk areas of China and Colombia. We examined the association between stomach cancer mortality and regular use (> or =15 times per month) of individual vitamin C supplements, individual vitamin E supplements, and multivitamins among 1,045,923 United States adults in the Cancer Prevention Study II (CPS-II) cohort. CPS-II participants completed a questionnaire at enrollment in 1982 and were followed for mortality through 1998. During follow-up, there were 1,725 stomach cancer deaths (1,127 in men and 598 in women). After adjustment for multiple potential stomach cancer risk factors, vitamin C use at enrollment was associated with reduced risk of stomach cancer mortality [rate ratio (RR), 0.83; 95% confidence interval (CI), 0.68-1.01]. However, this reduction in risk was observed only among participants with short duration use at enrollment (RR, 0.68; 95% CI, 0.51-0.91 for <10 years of use; RR, 1.00; 95% CI, 0.73-1.38 for > or =10 years of use). There was no association between stomach cancer mortality and regular use of vitamin E (RR, 1.02; 95% CI, 0.82-1.27) or multivitamins (RR, 0.89; 95% CI, 0.77-1.03), regardless of duration of use. Our results suggest that the use of vitamin C, vitamin E, or multivitamin supplements may not substantially reduce risk of stomach cancer mortality in North American populations in which stomach cancer rates are relatively low. Our results do not rule out effects of vitamin supplementation in areas in which stomach cancer rates are high and stomach cancer etiology may differ.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, GA 30329-4251, USA.

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    Source

    MeSH

    Adult
    Age Distribution
    Aged
    Aged, 80 and over
    Ascorbic Acid
    Cohort Studies
    Dietary Supplements
    Female
    Humans
    Male
    Middle Aged
    Primary Prevention
    Proportional Hazards Models
    Risk Factors
    Sex Distribution
    Stomach Neoplasms
    Survival Analysis
    Survival Rate
    United States
    Vitamin E

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    11815399

    Citation

    Jacobs, Eric J., et al. "Vitamin C, Vitamin E, and Multivitamin Supplement Use and Stomach Cancer Mortality in the Cancer Prevention Study II Cohort." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 11, no. 1, 2002, pp. 35-41.
    Jacobs EJ, Connell CJ, McCullough ML, et al. Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer Prevention Study II cohort. Cancer Epidemiol Biomarkers Prev. 2002;11(1):35-41.
    Jacobs, E. J., Connell, C. J., McCullough, M. L., Chao, A., Jonas, C. R., Rodriguez, C., ... Thun, M. J. (2002). Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer Prevention Study II cohort. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 11(1), pp. 35-41.
    Jacobs EJ, et al. Vitamin C, Vitamin E, and Multivitamin Supplement Use and Stomach Cancer Mortality in the Cancer Prevention Study II Cohort. Cancer Epidemiol Biomarkers Prev. 2002;11(1):35-41. PubMed PMID: 11815399.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer Prevention Study II cohort. AU - Jacobs,Eric J, AU - Connell,Cari J, AU - McCullough,Marjorie L, AU - Chao,Ann, AU - Jonas,Carolyn R, AU - Rodriguez,Carmen, AU - Calle,Eugenia E, AU - Thun,Michael J, PY - 2002/1/30/pubmed PY - 2002/3/15/medline PY - 2002/1/30/entrez SP - 35 EP - 41 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 11 IS - 1 N2 - Supplementation with antioxidant vitamins has been associated with decreased risk of stomach cancer or regression of precancerous lesions in high-risk areas of China and Colombia. We examined the association between stomach cancer mortality and regular use (> or =15 times per month) of individual vitamin C supplements, individual vitamin E supplements, and multivitamins among 1,045,923 United States adults in the Cancer Prevention Study II (CPS-II) cohort. CPS-II participants completed a questionnaire at enrollment in 1982 and were followed for mortality through 1998. During follow-up, there were 1,725 stomach cancer deaths (1,127 in men and 598 in women). After adjustment for multiple potential stomach cancer risk factors, vitamin C use at enrollment was associated with reduced risk of stomach cancer mortality [rate ratio (RR), 0.83; 95% confidence interval (CI), 0.68-1.01]. However, this reduction in risk was observed only among participants with short duration use at enrollment (RR, 0.68; 95% CI, 0.51-0.91 for <10 years of use; RR, 1.00; 95% CI, 0.73-1.38 for > or =10 years of use). There was no association between stomach cancer mortality and regular use of vitamin E (RR, 1.02; 95% CI, 0.82-1.27) or multivitamins (RR, 0.89; 95% CI, 0.77-1.03), regardless of duration of use. Our results suggest that the use of vitamin C, vitamin E, or multivitamin supplements may not substantially reduce risk of stomach cancer mortality in North American populations in which stomach cancer rates are relatively low. Our results do not rule out effects of vitamin supplementation in areas in which stomach cancer rates are high and stomach cancer etiology may differ. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/11815399/Vitamin_C_vitamin_E_and_multivitamin_supplement_use_and_stomach_cancer_mortality_in_the_Cancer_Prevention_Study_II_cohort_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=11815399 DB - PRIME DP - Unbound Medicine ER -