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Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism.
Horm Res. 2001; 56(1-2):25-31.HR

Abstract

OBJECTIVE

To evaluate the safety and efficacy of a low dose of flutamide (125 mg/day) in maintaining the clinical results already obtained using a higher dose (250 mg/day), in women suffering from hirsutism.

METHOD

Forty-three women suffering from hirsutism of varying origin received 250 mg/day of flutamide as an initial treatment for 12 months and, subsequently, 125 mg/day of flutamide for an additional 12 months as a maintenance treatment. Hirsutism was evaluated by the Ferriman-Gallwey score, and hair diameter and hair growth rate were determined by a special image analysis processor. Biochemical, clinical and hormonal parameters were evaluated in basal conditions and every 2-6 months.

RESULTS

The significant decrease in the hirsutism score, hair diameter and hair growth rate during the initial treatment period was confirmed at the end of the maintenance treatment period. Androgen levels decreased up to the end of the initial treatment period and partially decreased during the maintenance treatment. During the initial treatment period, 4 subjects showed an increase of aspartate aminotransferase and alanine aminotransferase and dropped out. During the maintenance treatment period, no side effects or complications were observed.

CONCLUSION

Satisfactory management of hirsutism with flutamide seems to be represented by an initial treatment period using 250 mg/day to achieve satisfactory results, followed by a long maintenance treatment period using 125 mg/day.

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Authors+Show Affiliations

Venturoli S
Reproductive Medicine Unit, Department of Gynecology and Obstetrics, University of Bologna, Italy. dirvent@med.unibo.it
Paradisi R
No affiliation info available
Bagnoli A
No affiliation info available
Colombo FM
No affiliation info available
Ravaioli B
No affiliation info available
Vianello F
No affiliation info available
Mancini F
No affiliation info available
Gualerzi B
No affiliation info available
Porcu E
No affiliation info available
Seracchioli R
No affiliation info available

MeSH

AdultAlanine TransaminaseAndrogen AntagonistsAspartate AminotransferasesDose-Response Relationship, DrugDrug Administration ScheduleFemaleFlutamideHirsutismHormonesHumansSingle-Blind MethodTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11815724

Citation

Venturoli, S, et al. "Low-dose Flutamide (125 Mg/day) as Maintenance Therapy in the Treatment of Hirsutism." Hormone Research, vol. 56, no. 1-2, 2001, pp. 25-31.
Venturoli S, Paradisi R, Bagnoli A, et al. Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism. Horm Res. 2001;56(1-2):25-31.
Venturoli, S., Paradisi, R., Bagnoli, A., Colombo, F. M., Ravaioli, B., Vianello, F., Mancini, F., Gualerzi, B., Porcu, E., & Seracchioli, R. (2001). Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism. Hormone Research, 56(1-2), 25-31.
Venturoli S, et al. Low-dose Flutamide (125 Mg/day) as Maintenance Therapy in the Treatment of Hirsutism. Horm Res. 2001;56(1-2):25-31. PubMed PMID: 11815724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism. AU - Venturoli,S, AU - Paradisi,R, AU - Bagnoli,A, AU - Colombo,F M, AU - Ravaioli,B, AU - Vianello,F, AU - Mancini,F, AU - Gualerzi,B, AU - Porcu,E, AU - Seracchioli,R, PY - 2002/1/30/pubmed PY - 2002/4/17/medline PY - 2002/1/30/entrez SP - 25 EP - 31 JF - Hormone research JO - Horm Res VL - 56 IS - 1-2 N2 - OBJECTIVE: To evaluate the safety and efficacy of a low dose of flutamide (125 mg/day) in maintaining the clinical results already obtained using a higher dose (250 mg/day), in women suffering from hirsutism. METHOD: Forty-three women suffering from hirsutism of varying origin received 250 mg/day of flutamide as an initial treatment for 12 months and, subsequently, 125 mg/day of flutamide for an additional 12 months as a maintenance treatment. Hirsutism was evaluated by the Ferriman-Gallwey score, and hair diameter and hair growth rate were determined by a special image analysis processor. Biochemical, clinical and hormonal parameters were evaluated in basal conditions and every 2-6 months. RESULTS: The significant decrease in the hirsutism score, hair diameter and hair growth rate during the initial treatment period was confirmed at the end of the maintenance treatment period. Androgen levels decreased up to the end of the initial treatment period and partially decreased during the maintenance treatment. During the initial treatment period, 4 subjects showed an increase of aspartate aminotransferase and alanine aminotransferase and dropped out. During the maintenance treatment period, no side effects or complications were observed. CONCLUSION: Satisfactory management of hirsutism with flutamide seems to be represented by an initial treatment period using 250 mg/day to achieve satisfactory results, followed by a long maintenance treatment period using 125 mg/day. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/11815724/Low_dose_flutamide__125_mg/day__as_maintenance_therapy_in_the_treatment_of_hirsutism_ L2 - https://www.karger.com?DOI=10.1159/000048086 DB - PRIME DP - Unbound Medicine ER -