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Role of the 4G/5G polymorphism of PaI-1 gene promoter on PaI-1 levels in obese patients: influence of fat distribution and insulin-resistance.
Thromb Haemost. 2001 Nov; 86(5):1161-9.TH

Abstract

As PAI-1, a cardiovascular risk factor linked to insulin-resistance, may be influenced by a 4G/5G gene polymorphism in disease states, we studied both PAI-1 plasma concentration (PAI-1:Ag) and 4G/5G polymorphism, and their relationship with anthropometric and endocrinemetabolic parameters in 93 obese patients and 79 lean normal subjects. In obese patients PAI-1:Ag levels were significantly increased, namely in males and in those with central obesity, and tightly related to the insulin-resistance parameters. In obese patients the 4G/5G polymorphism was a determinant of PAI-1:Ag levels, which were highest in 4G/4G, intermediate in 4G/5G and lowest in 5G/5G genotype carriers. PAI-1:Ag levels were significantly associated with most of anthropometric and endocrine-metabolic parameters only in 4G allele obese carriers. Moreover, only in patients with central obesity was the relationship between genotype and PAI-1 concentration maintained, with the highest levels in the 4G/4G patients. In each genotype subset of patients with central, but not peripheral, obesity PAI-1:Ag levels were significantly increased compared to their lean counterparts. In conclusion, the 4G/5G polymorphism may influence PAI-1 expression in obesity, with a crucial role in central but not peripheral adiposity. Since subjects with central obesity are at high risk for cardiovascular disease, the effects of the 4G/5G polymorphism on PAI-1 concentration may further enhance this risk.

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Authors+Show Affiliations

Sartori MT
Department of Medical and Surgical Sciences, University of Padua, Italy. mtsart@unipd.it
Vettor R
No affiliation info available
De Pergola G
No affiliation info available
De Mitrio V
No affiliation info available
Saggiorato G
No affiliation info available
Della Mea P
No affiliation info available
Patrassi GM
No affiliation info available
Lombardi AM
No affiliation info available
Fabris R
No affiliation info available
Girolami A
No affiliation info available

MeSH

AdultBiomarkersBlood PressureBody ConstitutionBody Mass IndexCase-Control StudiesFemaleGenotypeHumansInsulin ResistanceMaleMiddle AgedObesityPlasminogen Activator Inhibitor 1Polymorphism, GeneticPostmenopausePromoter Regions, GeneticSex Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11816701

Citation

Sartori, M T., et al. "Role of the 4G/5G Polymorphism of PaI-1 Gene Promoter On PaI-1 Levels in Obese Patients: Influence of Fat Distribution and Insulin-resistance." Thrombosis and Haemostasis, vol. 86, no. 5, 2001, pp. 1161-9.
Sartori MT, Vettor R, De Pergola G, et al. Role of the 4G/5G polymorphism of PaI-1 gene promoter on PaI-1 levels in obese patients: influence of fat distribution and insulin-resistance. Thromb Haemost. 2001;86(5):1161-9.
Sartori, M. T., Vettor, R., De Pergola, G., De Mitrio, V., Saggiorato, G., Della Mea, P., Patrassi, G. M., Lombardi, A. M., Fabris, R., & Girolami, A. (2001). Role of the 4G/5G polymorphism of PaI-1 gene promoter on PaI-1 levels in obese patients: influence of fat distribution and insulin-resistance. Thrombosis and Haemostasis, 86(5), 1161-9.
Sartori MT, et al. Role of the 4G/5G Polymorphism of PaI-1 Gene Promoter On PaI-1 Levels in Obese Patients: Influence of Fat Distribution and Insulin-resistance. Thromb Haemost. 2001;86(5):1161-9. PubMed PMID: 11816701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the 4G/5G polymorphism of PaI-1 gene promoter on PaI-1 levels in obese patients: influence of fat distribution and insulin-resistance. AU - Sartori,M T, AU - Vettor,R, AU - De Pergola,G, AU - De Mitrio,V, AU - Saggiorato,G, AU - Della Mea,P, AU - Patrassi,G M, AU - Lombardi,A M, AU - Fabris,R, AU - Girolami,A, PY - 2002/1/31/pubmed PY - 2003/4/5/medline PY - 2002/1/31/entrez SP - 1161 EP - 9 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 86 IS - 5 N2 - As PAI-1, a cardiovascular risk factor linked to insulin-resistance, may be influenced by a 4G/5G gene polymorphism in disease states, we studied both PAI-1 plasma concentration (PAI-1:Ag) and 4G/5G polymorphism, and their relationship with anthropometric and endocrinemetabolic parameters in 93 obese patients and 79 lean normal subjects. In obese patients PAI-1:Ag levels were significantly increased, namely in males and in those with central obesity, and tightly related to the insulin-resistance parameters. In obese patients the 4G/5G polymorphism was a determinant of PAI-1:Ag levels, which were highest in 4G/4G, intermediate in 4G/5G and lowest in 5G/5G genotype carriers. PAI-1:Ag levels were significantly associated with most of anthropometric and endocrine-metabolic parameters only in 4G allele obese carriers. Moreover, only in patients with central obesity was the relationship between genotype and PAI-1 concentration maintained, with the highest levels in the 4G/4G patients. In each genotype subset of patients with central, but not peripheral, obesity PAI-1:Ag levels were significantly increased compared to their lean counterparts. In conclusion, the 4G/5G polymorphism may influence PAI-1 expression in obesity, with a crucial role in central but not peripheral adiposity. Since subjects with central obesity are at high risk for cardiovascular disease, the effects of the 4G/5G polymorphism on PAI-1 concentration may further enhance this risk. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/11816701/Role_of_the_4G/5G_polymorphism_of_PaI_1_gene_promoter_on_PaI_1_levels_in_obese_patients:_influence_of_fat_distribution_and_insulin_resistance_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11816701.ui DB - PRIME DP - Unbound Medicine ER -