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Listeria meningoencephalitis: two cases and a review of the literature.
Ann Acad Med Singapore. 2001 Nov; 30(6):659-63.AA

Abstract

INTRODUCTION

Although presently uncommon locally, Listeria is increasing an important cause of central nervous system (CNS) infection worldwide. It differs from the common meningitis pathogens in its clinical features and treatment.

CLINICAL PICTURE

We present 2 recently encountered cases of Listeria meningoencephalitis. In case 1, a previously healthy 42-year-old man presented with clinical features of meningoencephalitis. In case 2, a 64-year-old woman had clinical features of pneumonia and meningoencephalitis. Both had a predominantly lymphocytic picture in their cerebrospinal fluid (CSF) samples. Listeria grew in blood cultures of both patients and the CSF culture of the first.

TREATMENT

In both cases, Listeria was resistant to the empirical antibiotics used. Intravenous ampicillin was eventually used in both patients, with gentamicin, added for synergistic action in the first.

OUTCOME

The first patient developed complications of hydrocephalus, subdural collection and extensive cerebritis and ventriculitis. The second patient had focal seizures and a pontine infarct. Both did not survive.

CONCLUSION

These 2 recent cases with different presentations of intracranial listerosis highlight the increasing importance of listerial infections in Singapore. Clinicians need to be familiar with the features of this lethal disease in order to recognize and manage it successfully.

Authors+Show Affiliations

Division of Neurology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074. chanyc@nuh.com.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

11817300

Citation

Chan, Y C., et al. "Listeria Meningoencephalitis: Two Cases and a Review of the Literature." Annals of the Academy of Medicine, Singapore, vol. 30, no. 6, 2001, pp. 659-63.
Chan YC, Ho KH, Tambyah PA, et al. Listeria meningoencephalitis: two cases and a review of the literature. Ann Acad Med Singap. 2001;30(6):659-63.
Chan, Y. C., Ho, K. H., Tambyah, P. A., Lee, K. H., & Ong, B. K. (2001). Listeria meningoencephalitis: two cases and a review of the literature. Annals of the Academy of Medicine, Singapore, 30(6), 659-63.
Chan YC, et al. Listeria Meningoencephalitis: Two Cases and a Review of the Literature. Ann Acad Med Singap. 2001;30(6):659-63. PubMed PMID: 11817300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Listeria meningoencephalitis: two cases and a review of the literature. AU - Chan,Y C, AU - Ho,K H, AU - Tambyah,P A, AU - Lee,K H, AU - Ong,B K, PY - 2002/1/31/pubmed PY - 2002/3/23/medline PY - 2002/1/31/entrez SP - 659 EP - 63 JF - Annals of the Academy of Medicine, Singapore JO - Ann. Acad. Med. Singap. VL - 30 IS - 6 N2 - INTRODUCTION: Although presently uncommon locally, Listeria is increasing an important cause of central nervous system (CNS) infection worldwide. It differs from the common meningitis pathogens in its clinical features and treatment. CLINICAL PICTURE: We present 2 recently encountered cases of Listeria meningoencephalitis. In case 1, a previously healthy 42-year-old man presented with clinical features of meningoencephalitis. In case 2, a 64-year-old woman had clinical features of pneumonia and meningoencephalitis. Both had a predominantly lymphocytic picture in their cerebrospinal fluid (CSF) samples. Listeria grew in blood cultures of both patients and the CSF culture of the first. TREATMENT: In both cases, Listeria was resistant to the empirical antibiotics used. Intravenous ampicillin was eventually used in both patients, with gentamicin, added for synergistic action in the first. OUTCOME: The first patient developed complications of hydrocephalus, subdural collection and extensive cerebritis and ventriculitis. The second patient had focal seizures and a pontine infarct. Both did not survive. CONCLUSION: These 2 recent cases with different presentations of intracranial listerosis highlight the increasing importance of listerial infections in Singapore. Clinicians need to be familiar with the features of this lethal disease in order to recognize and manage it successfully. SN - 0304-4602 UR - https://www.unboundmedicine.com/medline/citation/11817300/Listeria_meningoencephalitis:_two_cases_and_a_review_of_the_literature L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -