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SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice.

Abstract

This study reports a series of spatial discrimination procedures in a Morris-type maze to investigate the effects of delta9-tetrahydrocannabinol (delta9-THC) on different phases of learning and memory in mice. Adult male mice were given training trails to find the submerged platform at a fixed location in the water maze adapted for mice. In additional experiments, mice were trained with the repeated acquisition procedure to test the working memory. Results indicate that delta9-THC (8 mg/kg i.p.) 30 min pretest impaired specifically the acquisition of spatial learning and the performance of mice in the working memory task, while consolidation and retrieval of a previously learned task were not affected. There was no evidence of motoric difficulty, as the number of quadrant line crossings was not decreased and no visible sign of sensorimotor disturbance was observed during swimming. Pretreatment with SR 141716A (1 mg/kg i.p.), a CB1 cannabinoid receptor antagonist, significantly prevented the learning deficits in the water maze. These findings show that delta9-THC impairs spatial discrimination learning in a selective way in the water maze in mice and that these deficits may be mediated by cannabinoid receptors.

Authors+Show Affiliations

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11817511

Citation

Da, SilvaGeorgeE, and Reinaldo N. Takahashi. "SR 141716A Prevents Delta 9-tetrahydrocannabinol-induced Spatial Learning Deficit in a Morris-type Water Maze in Mice." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 26, no. 2, 2002, pp. 321-5.
Da S, Takahashi RN. SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(2):321-5.
Da, S., & Takahashi, R. N. (2002). SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice. Progress in Neuro-psychopharmacology & Biological Psychiatry, 26(2), 321-5.
Da S, Takahashi RN. SR 141716A Prevents Delta 9-tetrahydrocannabinol-induced Spatial Learning Deficit in a Morris-type Water Maze in Mice. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(2):321-5. PubMed PMID: 11817511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice. AU - Da,SilvaGeorgeE, AU - Takahashi,Reinaldo N, PY - 2002/1/31/pubmed PY - 2002/7/23/medline PY - 2002/1/31/entrez SP - 321 EP - 5 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 26 IS - 2 N2 - This study reports a series of spatial discrimination procedures in a Morris-type maze to investigate the effects of delta9-tetrahydrocannabinol (delta9-THC) on different phases of learning and memory in mice. Adult male mice were given training trails to find the submerged platform at a fixed location in the water maze adapted for mice. In additional experiments, mice were trained with the repeated acquisition procedure to test the working memory. Results indicate that delta9-THC (8 mg/kg i.p.) 30 min pretest impaired specifically the acquisition of spatial learning and the performance of mice in the working memory task, while consolidation and retrieval of a previously learned task were not affected. There was no evidence of motoric difficulty, as the number of quadrant line crossings was not decreased and no visible sign of sensorimotor disturbance was observed during swimming. Pretreatment with SR 141716A (1 mg/kg i.p.), a CB1 cannabinoid receptor antagonist, significantly prevented the learning deficits in the water maze. These findings show that delta9-THC impairs spatial discrimination learning in a selective way in the water maze in mice and that these deficits may be mediated by cannabinoid receptors. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/11817511/SR_141716A_prevents_delta_9_tetrahydrocannabinol_induced_spatial_learning_deficit_in_a_Morris_type_water_maze_in_mice_ L2 - https://medlineplus.gov/memory.html DB - PRIME DP - Unbound Medicine ER -