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The prevalence of gastric autoantibodies in chronic alcoholics.
Am J Gastroenterol. 1975 Sep; 64(3):187-90.AJ

Abstract

One hundred fifty alcoholic men and women and 150 age and sex-matched nonalcoholic controls (after exclusion of pernicious anemia and cancer of the stomach) were evaluated for the presence of parietal cell antibodies (PCA). Blocking and binding intrinsic factor antibodies (IFA) were determined in the PCA positive sera. The prevalence and age and sex distribution of PCA in the alcoholics and nonalcoholics was identical. In alcoholics above the age of 60 years, the incidence of PCA, although higher than in those of the younger age group was similar to that in the nonalcoholics of the same age group (in men 6.3 percent and 7.3 percent and in women 7.5 percent and 10.0 percent respectively). Antral gastritis of moderate or severe degree was the frequent lesion in alcoholics. This form of gastritis was not associated with any significant increase in the incidence of PCA. No patients with sera positive for IFA were detected among the 22 PCA positive patients. There is no evidence for humoral derangement of the gastric autoimmunity in chronic alcoholics.

Authors

Pitchumoni CS
No affiliation info available
Lopes JD
No affiliation info available
Glass GB
No affiliation info available

MeSH

AdultAge FactorsAgedAlcoholismAntibodiesAutoantibodiesBiopsyFemaleGastric MucosaGastritisHumansIntrinsic FactorMaleMiddle Aged

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1181922

Citation

Pitchumoni, C S., et al. "The Prevalence of Gastric Autoantibodies in Chronic Alcoholics." The American Journal of Gastroenterology, vol. 64, no. 3, 1975, pp. 187-90.
Pitchumoni CS, Lopes JD, Glass GB. The prevalence of gastric autoantibodies in chronic alcoholics. Am J Gastroenterol. 1975;64(3):187-90.
Pitchumoni, C. S., Lopes, J. D., & Glass, G. B. (1975). The prevalence of gastric autoantibodies in chronic alcoholics. The American Journal of Gastroenterology, 64(3), 187-90.
Pitchumoni CS, Lopes JD, Glass GB. The Prevalence of Gastric Autoantibodies in Chronic Alcoholics. Am J Gastroenterol. 1975;64(3):187-90. PubMed PMID: 1181922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of gastric autoantibodies in chronic alcoholics. AU - Pitchumoni,C S, AU - Lopes,J D, AU - Glass,G B, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 187 EP - 90 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 64 IS - 3 N2 - One hundred fifty alcoholic men and women and 150 age and sex-matched nonalcoholic controls (after exclusion of pernicious anemia and cancer of the stomach) were evaluated for the presence of parietal cell antibodies (PCA). Blocking and binding intrinsic factor antibodies (IFA) were determined in the PCA positive sera. The prevalence and age and sex distribution of PCA in the alcoholics and nonalcoholics was identical. In alcoholics above the age of 60 years, the incidence of PCA, although higher than in those of the younger age group was similar to that in the nonalcoholics of the same age group (in men 6.3 percent and 7.3 percent and in women 7.5 percent and 10.0 percent respectively). Antral gastritis of moderate or severe degree was the frequent lesion in alcoholics. This form of gastritis was not associated with any significant increase in the incidence of PCA. No patients with sera positive for IFA were detected among the 22 PCA positive patients. There is no evidence for humoral derangement of the gastric autoimmunity in chronic alcoholics. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/1181922/The_prevalence_of_gastric_autoantibodies_in_chronic_alcoholics_ DB - PRIME DP - Unbound Medicine ER -