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Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model.
Nat Med 2002; 8(2):136-42NMed

Abstract

Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms remain controversial and poorly understood. Here we establish a link between migraine aura and headache by demonstrating that cortical spreading depression, implicated in migraine visual aura, activates trigeminovascular afferents and evokes a series of cortical meningeal and brainstem events consistent with the development of headache. Cortical spreading depression caused long-lasting blood-flow enhancement selectively within the middle meningeal artery dependent upon trigeminal and parasympathetic activation, and plasma protein leakage within the dura mater in part by a neurokinin-1-receptor mechanism. Our findings provide a neural mechanism by which extracerebral cephalic blood flow couples to brain events; this mechanism explains vasodilation during headache and links intense neurometabolic brain activity with the transmission of headache pain by the trigeminal nerve.

Authors+Show Affiliations

Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11821897

Citation

Bolay, Hayrunnisa, et al. "Intrinsic Brain Activity Triggers Trigeminal Meningeal Afferents in a Migraine Model." Nature Medicine, vol. 8, no. 2, 2002, pp. 136-42.
Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med. 2002;8(2):136-42.
Bolay, H., Reuter, U., Dunn, A. K., Huang, Z., Boas, D. A., & Moskowitz, M. A. (2002). Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature Medicine, 8(2), pp. 136-42.
Bolay H, et al. Intrinsic Brain Activity Triggers Trigeminal Meningeal Afferents in a Migraine Model. Nat Med. 2002;8(2):136-42. PubMed PMID: 11821897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. AU - Bolay,Hayrunnisa, AU - Reuter,Uwe, AU - Dunn,Andrew K, AU - Huang,Zhihong, AU - Boas,David A, AU - Moskowitz,Michael A, PY - 2002/2/1/pubmed PY - 2002/5/4/medline PY - 2002/2/1/entrez SP - 136 EP - 42 JF - Nature medicine JO - Nat. Med. VL - 8 IS - 2 N2 - Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms remain controversial and poorly understood. Here we establish a link between migraine aura and headache by demonstrating that cortical spreading depression, implicated in migraine visual aura, activates trigeminovascular afferents and evokes a series of cortical meningeal and brainstem events consistent with the development of headache. Cortical spreading depression caused long-lasting blood-flow enhancement selectively within the middle meningeal artery dependent upon trigeminal and parasympathetic activation, and plasma protein leakage within the dura mater in part by a neurokinin-1-receptor mechanism. Our findings provide a neural mechanism by which extracerebral cephalic blood flow couples to brain events; this mechanism explains vasodilation during headache and links intense neurometabolic brain activity with the transmission of headache pain by the trigeminal nerve. SN - 1078-8956 UR - https://www.unboundmedicine.com/medline/citation/11821897/Intrinsic_brain_activity_triggers_trigeminal_meningeal_afferents_in_a_migraine_model_ L2 - http://dx.doi.org/10.1038/nm0202-136 DB - PRIME DP - Unbound Medicine ER -