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[Portal hypertensive gastropathy in patients with cirrhosis of the liver].
Recenti Prog Med. 2001 Dec; 92(12):735-40.RP

Abstract

Portal hypertensive gastropathy (PHG) is characterized by changes in the endoscopic appearance of the gastric mucosa, specific for portal hypertension. The identification of the elementary lesions of PHG allowed the development of a reproducible classification, defining mild and severe pictures, and the execution of a natural history study. This study showed a 80% overall prevalence of PHG in patient with cirrhosis of the liver and a correlation between duration of the disease and development of PHG. PHG has often been shown to be a fluctuating condition, thus suggesting that its pathophysiology is not only related to portal hypertension, but also to other, yet unknown, factors. Bleeding from PHG did not occur in patients with a recent diagnosis of liver cirrhosis. Acute and chronic bleeding occurred in 2.5% and 12% of patients, respectively. The death rate from acute PHG bleeding was lower (12.5%) than the death rate of variceal bleeding (39.1%). Vasoactive drugs can be used in the treatment of acute PHG bleeding. For chronic bleeding, non selective 13-blockers and, if needed, iron, are the treatment of choice. TIPS or surgical portosystemic shunt may be considered for acute or chronic PHG bleeding, if medical treatment fails. Clinical controlled trials are needed to evaluate the efficacy of these or other treatments.

Authors+Show Affiliations

Servizio di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Interna, IRCCS Ospedale Maggiore, Milano. gastro@polic.cilea.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ita

PubMed ID

11822093

Citation

Primignani, M, et al. "[Portal Hypertensive Gastropathy in Patients With Cirrhosis of the Liver]." Recenti Progressi in Medicina, vol. 92, no. 12, 2001, pp. 735-40.
Primignani M, Dell'Era A, Fazzini L, et al. [Portal hypertensive gastropathy in patients with cirrhosis of the liver]. Recenti Prog Med. 2001;92(12):735-40.
Primignani, M., Dell'Era, A., Fazzini, L., Zatelli, S., & de Franchis, R. (2001). [Portal hypertensive gastropathy in patients with cirrhosis of the liver]. Recenti Progressi in Medicina, 92(12), 735-40.
Primignani M, et al. [Portal Hypertensive Gastropathy in Patients With Cirrhosis of the Liver]. Recenti Prog Med. 2001;92(12):735-40. PubMed PMID: 11822093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Portal hypertensive gastropathy in patients with cirrhosis of the liver]. AU - Primignani,M, AU - Dell'Era,A, AU - Fazzini,L, AU - Zatelli,S, AU - de Franchis,R, PY - 2002/2/2/pubmed PY - 2002/2/20/medline PY - 2002/2/2/entrez SP - 735 EP - 40 JF - Recenti progressi in medicina JO - Recenti Prog Med VL - 92 IS - 12 N2 - Portal hypertensive gastropathy (PHG) is characterized by changes in the endoscopic appearance of the gastric mucosa, specific for portal hypertension. The identification of the elementary lesions of PHG allowed the development of a reproducible classification, defining mild and severe pictures, and the execution of a natural history study. This study showed a 80% overall prevalence of PHG in patient with cirrhosis of the liver and a correlation between duration of the disease and development of PHG. PHG has often been shown to be a fluctuating condition, thus suggesting that its pathophysiology is not only related to portal hypertension, but also to other, yet unknown, factors. Bleeding from PHG did not occur in patients with a recent diagnosis of liver cirrhosis. Acute and chronic bleeding occurred in 2.5% and 12% of patients, respectively. The death rate from acute PHG bleeding was lower (12.5%) than the death rate of variceal bleeding (39.1%). Vasoactive drugs can be used in the treatment of acute PHG bleeding. For chronic bleeding, non selective 13-blockers and, if needed, iron, are the treatment of choice. TIPS or surgical portosystemic shunt may be considered for acute or chronic PHG bleeding, if medical treatment fails. Clinical controlled trials are needed to evaluate the efficacy of these or other treatments. SN - 0034-1193 UR - https://www.unboundmedicine.com/medline/citation/11822093/[Portal_hypertensive_gastropathy_in_patients_with_cirrhosis_of_the_liver]_ L2 - https://medlineplus.gov/stomachdisorders.html DB - PRIME DP - Unbound Medicine ER -