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Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro.
Exp Neurol. 2002 Feb; 173(2):224-34.EN

Abstract

Spinal cord injury is a major cause of disability and results in many serious physical, psychological, and social difficulties. Numerous studies have shown that traumatic spinal cord injuries (SCI) lead to neuronal loss and axonal degeneration in and around the injury site that cause partial disability or complete paralysis. An important strategy in the treatment of SCI is to promote neuron survival and axon outgrowth, making possible the recovery of neural connections. Using an in vitro survival assay, we have identified ginsenosides Rb1 and Rg1, extracted from ginseng root (Panax ginseng C. A. Meyer), as efficient neuroprotective agents for spinal cord neurons. These compounds protect spinal neurons from excitotoxicity induced by glutamate and kainic acid, as well as oxidative stress induced by H(2)O(2). The neuroprotective effects are dose-dependent. The optimal doses are 20-40 microM for ginsenosides Rb1 and Rg1. The effects are specific for Rb1 and Rg1, since a third ginsenoside, Re, did not exhibit any activity. Ginseng has been used for thousands of years in the treatment of neurological disorders and other diseases in Asia. Ginsenosides Rb1 and Rg1 represent potentially effective therapeutic agents for spinal cord injuries.

Authors+Show Affiliations

Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers University, Piscataway, New Jersey 08854, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11822886

Citation

Liao, Baisong, et al. "Neuroprotective Effects of Ginseng Total Saponin and Ginsenosides Rb1 and Rg1 On Spinal Cord Neurons in Vitro." Experimental Neurology, vol. 173, no. 2, 2002, pp. 224-34.
Liao B, Newmark H, Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol. 2002;173(2):224-34.
Liao, B., Newmark, H., & Zhou, R. (2002). Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Experimental Neurology, 173(2), 224-34.
Liao B, Newmark H, Zhou R. Neuroprotective Effects of Ginseng Total Saponin and Ginsenosides Rb1 and Rg1 On Spinal Cord Neurons in Vitro. Exp Neurol. 2002;173(2):224-34. PubMed PMID: 11822886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. AU - Liao,Baisong, AU - Newmark,Harold, AU - Zhou,Renping, PY - 2002/2/2/pubmed PY - 2002/3/1/medline PY - 2002/2/2/entrez SP - 224 EP - 34 JF - Experimental neurology JO - Exp Neurol VL - 173 IS - 2 N2 - Spinal cord injury is a major cause of disability and results in many serious physical, psychological, and social difficulties. Numerous studies have shown that traumatic spinal cord injuries (SCI) lead to neuronal loss and axonal degeneration in and around the injury site that cause partial disability or complete paralysis. An important strategy in the treatment of SCI is to promote neuron survival and axon outgrowth, making possible the recovery of neural connections. Using an in vitro survival assay, we have identified ginsenosides Rb1 and Rg1, extracted from ginseng root (Panax ginseng C. A. Meyer), as efficient neuroprotective agents for spinal cord neurons. These compounds protect spinal neurons from excitotoxicity induced by glutamate and kainic acid, as well as oxidative stress induced by H(2)O(2). The neuroprotective effects are dose-dependent. The optimal doses are 20-40 microM for ginsenosides Rb1 and Rg1. The effects are specific for Rb1 and Rg1, since a third ginsenoside, Re, did not exhibit any activity. Ginseng has been used for thousands of years in the treatment of neurological disorders and other diseases in Asia. Ginsenosides Rb1 and Rg1 represent potentially effective therapeutic agents for spinal cord injuries. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/11822886/Neuroprotective_effects_of_ginseng_total_saponin_and_ginsenosides_Rb1_and_Rg1_on_spinal_cord_neurons_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014488601978410 DB - PRIME DP - Unbound Medicine ER -