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The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene.
J Nutr 2002; 132(2):283-8JN

Abstract

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status. Because MTHFR contains flavin adenine dinucleotide (FAD) as a prosthetic group, riboflavin status may also influence homocysteine metabolism. The objective of this study was to examine the association between riboflavin status and fasting plasma total homocysteine (tHcy) concentration while also considering MTHFR C677T genotype and folate status. The study was conducted using fasting plasma samples (n = 450) from the fifth examination of the Framingham Offspring Study cohort. All persons with the TT genotype and age- and sex-matched sets of individuals with the CT and CC genotypes were selected for determination of plasma riboflavin and flavin mono- and dinucleotide levels. Plasma riboflavin was associated with tHcy concentrations, but the association was largely confined to persons with plasma folate <12.5 nmol/L and TT genotype. In these persons, the mean tHcy among individuals with riboflavin levels <6.89 nmol/L was 14.5 micromol/L, whereas the mean tHcy for those with riboflavin > or = 11 nmol/L was 11.6 micromol/L (P-trend <0.03). Plasma flavin nucleotides were unrelated to tHcy concentrations. Our data suggest that riboflavin status may affect homocysteine metabolism, but only in a small segment of the population who have both low folate status and are homozygotes for the MTHFR C677T mutation.

Authors+Show Affiliations

Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. paul@hnrc.tufts.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11823591

Citation

Jacques, Paul F., et al. "The Relationship Between Riboflavin and Plasma Total Homocysteine in the Framingham Offspring Cohort Is Influenced By Folate Status and the C677T Transition in the Methylenetetrahydrofolate Reductase Gene." The Journal of Nutrition, vol. 132, no. 2, 2002, pp. 283-8.
Jacques PF, Kalmbach R, Bagley PJ, et al. The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr. 2002;132(2):283-8.
Jacques, P. F., Kalmbach, R., Bagley, P. J., Russo, G. T., Rogers, G., Wilson, P. W., ... Selhub, J. (2002). The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. The Journal of Nutrition, 132(2), pp. 283-8.
Jacques PF, et al. The Relationship Between Riboflavin and Plasma Total Homocysteine in the Framingham Offspring Cohort Is Influenced By Folate Status and the C677T Transition in the Methylenetetrahydrofolate Reductase Gene. J Nutr. 2002;132(2):283-8. PubMed PMID: 11823591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. AU - Jacques,Paul F, AU - Kalmbach,Renee, AU - Bagley,Pamela J, AU - Russo,Giuseppina T, AU - Rogers,Gail, AU - Wilson,Peter W F, AU - Rosenberg,Irwin H, AU - Selhub,Jacob, PY - 2002/2/2/pubmed PY - 2002/3/7/medline PY - 2002/2/2/entrez SP - 283 EP - 8 JF - The Journal of nutrition JO - J. Nutr. VL - 132 IS - 2 N2 - Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status. Because MTHFR contains flavin adenine dinucleotide (FAD) as a prosthetic group, riboflavin status may also influence homocysteine metabolism. The objective of this study was to examine the association between riboflavin status and fasting plasma total homocysteine (tHcy) concentration while also considering MTHFR C677T genotype and folate status. The study was conducted using fasting plasma samples (n = 450) from the fifth examination of the Framingham Offspring Study cohort. All persons with the TT genotype and age- and sex-matched sets of individuals with the CT and CC genotypes were selected for determination of plasma riboflavin and flavin mono- and dinucleotide levels. Plasma riboflavin was associated with tHcy concentrations, but the association was largely confined to persons with plasma folate <12.5 nmol/L and TT genotype. In these persons, the mean tHcy among individuals with riboflavin levels <6.89 nmol/L was 14.5 micromol/L, whereas the mean tHcy for those with riboflavin > or = 11 nmol/L was 11.6 micromol/L (P-trend <0.03). Plasma flavin nucleotides were unrelated to tHcy concentrations. Our data suggest that riboflavin status may affect homocysteine metabolism, but only in a small segment of the population who have both low folate status and are homozygotes for the MTHFR C677T mutation. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11823591/The_relationship_between_riboflavin_and_plasma_total_homocysteine_in_the_Framingham_Offspring_cohort_is_influenced_by_folate_status_and_the_C677T_transition_in_the_methylenetetrahydrofolate_reductase_gene_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/132.2.283 DB - PRIME DP - Unbound Medicine ER -