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Prophylactic and curative effects of Bacopa monniera in gastric ulcer models.
Phytomedicine. 2001 Nov; 8(6):423-30.P

Abstract

Bacopa monniera Wettst. (BM, syn. Herpestis monniera L; Scrophulariaceae), is an Ayurvedic drug used as a rasayana. Its fresh juice was earlier reported to have significant antiulcerogenic activity. In continuation, methanolic extract of BM (BME) standardized to bacoside-A content (percentage-38.0 +/- 0.9), when given in the dose of 10-50 mg/kg, twice daily for 5 days, showed dose-dependent anti-ulcerogenic on various gastric ulcer models induced by ethanol, aspirin, 2 h cold restraint stress and 4 h pylorus ligation. BME in the dose of 20 mg/kg, given for 10 days, twice daily showed healing effects against 50% acetic acid-induced gastric ulcers. Further work was done to investigate the possible mechanisms of its action by studying its effect on various mucosal offensive acid-pepsin secretion and defensive factors like mucin secretion, mucosal cell shedding, cell proliferation and antioxidant activity in rats. BME 20 mg/kg showed no effect on acid-pepsin secretion, increased mucin secretion, while it decreased cell shedding with no effect on cell proliferation. BME showed significant antioxidant effect per se and in stressed animals. Thus, the gastric prophylactic and curative effects of BME may be due to its predominant effect on mucosal defensive factors.

Authors+Show Affiliations

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11824516

Citation

Sairam, K, et al. "Prophylactic and Curative Effects of Bacopa Monniera in Gastric Ulcer Models." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 8, no. 6, 2001, pp. 423-30.
Sairam K, Rao CV, Babu MD, et al. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine. 2001;8(6):423-30.
Sairam, K., Rao, C. V., Babu, M. D., & Goel, R. K. (2001). Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 8(6), 423-30.
Sairam K, et al. Prophylactic and Curative Effects of Bacopa Monniera in Gastric Ulcer Models. Phytomedicine. 2001;8(6):423-30. PubMed PMID: 11824516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. AU - Sairam,K, AU - Rao,C V, AU - Babu,M D, AU - Goel,R K, PY - 2002/2/5/pubmed PY - 2002/8/7/medline PY - 2002/2/5/entrez SP - 423 EP - 30 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 8 IS - 6 N2 - Bacopa monniera Wettst. (BM, syn. Herpestis monniera L; Scrophulariaceae), is an Ayurvedic drug used as a rasayana. Its fresh juice was earlier reported to have significant antiulcerogenic activity. In continuation, methanolic extract of BM (BME) standardized to bacoside-A content (percentage-38.0 +/- 0.9), when given in the dose of 10-50 mg/kg, twice daily for 5 days, showed dose-dependent anti-ulcerogenic on various gastric ulcer models induced by ethanol, aspirin, 2 h cold restraint stress and 4 h pylorus ligation. BME in the dose of 20 mg/kg, given for 10 days, twice daily showed healing effects against 50% acetic acid-induced gastric ulcers. Further work was done to investigate the possible mechanisms of its action by studying its effect on various mucosal offensive acid-pepsin secretion and defensive factors like mucin secretion, mucosal cell shedding, cell proliferation and antioxidant activity in rats. BME 20 mg/kg showed no effect on acid-pepsin secretion, increased mucin secretion, while it decreased cell shedding with no effect on cell proliferation. BME showed significant antioxidant effect per se and in stressed animals. Thus, the gastric prophylactic and curative effects of BME may be due to its predominant effect on mucosal defensive factors. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/11824516/Prophylactic_and_curative_effects_of_Bacopa_monniera_in_gastric_ulcer_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(04)70060-4 DB - PRIME DP - Unbound Medicine ER -