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Altered levels of soluble adhesion molecules in patients with rheumatoid arthritis complicated by peripheral neuropathy.
J Rheumatol. 2002 Jan; 29(1):57-61.JR

Abstract

OBJECTIVE

To assess levels of 2 circulating soluble adhesion molecules, vascular cellular adhesion molecule (sVCAM) and E-selectin, in patients with rheumatoid arthritis (RA) complicated by peripheral neuropathy compared to RA patients with no neurological complications and healthy controls.

METHODS

In total, 25 RA patients with peripheral neuropathy (detected by clinical examination and confirmed by electromyography and nerve conduction studies), 40 RA patients without peripheral neuropathy, and 25 controls were studied. Clinical and laboratory assessments of disease activity were carried out and levels of sVCAM-1 and E-selectin were measured by ELISA in each of the 3 groups.

RESULTS

Levels of sVCAM-1 and sE-selectin were higher (p < 0.001) in RA patients with peripheral neuropathy than in patients without neuropathy and controls. Levels of sE-selectin and sVCAM-1 correlated positively with disease activity variables. Correlation was independent of age and sex.

CONCLUSION

Peripheral neuropathy in patients with RA is associated with increased endothelial cell activation evidenced by elevated serum levels of sVCAM-1 and sE-selectin in this group of patients.

Authors+Show Affiliations

Rheumatology and Rehabilitation Department, Cairo University, Egypt. miedanycrd@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11824972

Citation

El, MiedanyYasserM, et al. "Altered Levels of Soluble Adhesion Molecules in Patients With Rheumatoid Arthritis Complicated By Peripheral Neuropathy." The Journal of Rheumatology, vol. 29, no. 1, 2002, pp. 57-61.
El M, Ashour S, Moustafa H, et al. Altered levels of soluble adhesion molecules in patients with rheumatoid arthritis complicated by peripheral neuropathy. J Rheumatol. 2002;29(1):57-61.
El, M., Ashour, S., Moustafa, H., & Ahmed, I. (2002). Altered levels of soluble adhesion molecules in patients with rheumatoid arthritis complicated by peripheral neuropathy. The Journal of Rheumatology, 29(1), 57-61.
El M, et al. Altered Levels of Soluble Adhesion Molecules in Patients With Rheumatoid Arthritis Complicated By Peripheral Neuropathy. J Rheumatol. 2002;29(1):57-61. PubMed PMID: 11824972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered levels of soluble adhesion molecules in patients with rheumatoid arthritis complicated by peripheral neuropathy. AU - El,MiedanyYasserM, AU - Ashour,Samia, AU - Moustafa,Hossam, AU - Ahmed,Ihab, PY - 2002/2/5/pubmed PY - 2002/7/3/medline PY - 2002/2/5/entrez SP - 57 EP - 61 JF - The Journal of rheumatology JO - J Rheumatol VL - 29 IS - 1 N2 - OBJECTIVE: To assess levels of 2 circulating soluble adhesion molecules, vascular cellular adhesion molecule (sVCAM) and E-selectin, in patients with rheumatoid arthritis (RA) complicated by peripheral neuropathy compared to RA patients with no neurological complications and healthy controls. METHODS: In total, 25 RA patients with peripheral neuropathy (detected by clinical examination and confirmed by electromyography and nerve conduction studies), 40 RA patients without peripheral neuropathy, and 25 controls were studied. Clinical and laboratory assessments of disease activity were carried out and levels of sVCAM-1 and E-selectin were measured by ELISA in each of the 3 groups. RESULTS: Levels of sVCAM-1 and sE-selectin were higher (p < 0.001) in RA patients with peripheral neuropathy than in patients without neuropathy and controls. Levels of sE-selectin and sVCAM-1 correlated positively with disease activity variables. Correlation was independent of age and sex. CONCLUSION: Peripheral neuropathy in patients with RA is associated with increased endothelial cell activation evidenced by elevated serum levels of sVCAM-1 and sE-selectin in this group of patients. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/11824972/Altered_levels_of_soluble_adhesion_molecules_in_patients_with_rheumatoid_arthritis_complicated_by_peripheral_neuropathy_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=11824972 DB - PRIME DP - Unbound Medicine ER -