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Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats.
Jpn J Pharmacol. 2001 Dec; 87(4):297-308.JJ

Abstract

We investigated the characteristics of delta9-tetrahydrocannabinol (THC)-induced impairment of learning and memory using an 8-arm radial maze task, a water maze, a visual discrimination task with 2 figures and a passive avoidance test in rats. THC (6 mg/kg, i.p.) impaired spatial memory in the standard task of the 8-arm radial maze. THC (4-6 mg/kg, i.p.) selectively impaired working memory in a reference and working memory task of the 8-arm radial maze. Even at a dose of 10 mg/kg, THC did not impair spatial memory in the water maze. In addition, THC at a dose of 6 mg/kg, which had inhibitory effects in the 8-arm radial maze, did not affect performance in the visual discrimination task. These results indicate that at low doses (2-6 mg/kg), THC may not produce visual function abnormalities. THC impaired retrieval (6 mg/kg, i.p.) as well as acquisition (10 mg/kg, i.p.) in the passive avoidance test. The consolidation process was also impaired by i.c.v. injection (100 microg), but not i.p. injection (6-10 mg/kg) of THC. These results suggest that THC-induced impairment of spatial memory is based on the selective impairment of working memory through its effects on acquisition and retrieval processes.

Authors+Show Affiliations

Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11829149

Citation

Mishima, K, et al. "Characteristics of Learning and Memory Impairment Induced By Delta9-tetrahydrocannabinol in Rats." Japanese Journal of Pharmacology, vol. 87, no. 4, 2001, pp. 297-308.
Mishima K, Egashira N, Hirosawa N, et al. Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats. Jpn J Pharmacol. 2001;87(4):297-308.
Mishima, K., Egashira, N., Hirosawa, N., Fujii, M., Matsumoto, Y., Iwasaki, K., & Fujiwara, M. (2001). Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats. Japanese Journal of Pharmacology, 87(4), 297-308.
Mishima K, et al. Characteristics of Learning and Memory Impairment Induced By Delta9-tetrahydrocannabinol in Rats. Jpn J Pharmacol. 2001;87(4):297-308. PubMed PMID: 11829149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats. AU - Mishima,K, AU - Egashira,N, AU - Hirosawa,N, AU - Fujii,M, AU - Matsumoto,Y, AU - Iwasaki,K, AU - Fujiwara,M, PY - 2002/2/7/pubmed PY - 2002/7/24/medline PY - 2002/2/7/entrez SP - 297 EP - 308 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 87 IS - 4 N2 - We investigated the characteristics of delta9-tetrahydrocannabinol (THC)-induced impairment of learning and memory using an 8-arm radial maze task, a water maze, a visual discrimination task with 2 figures and a passive avoidance test in rats. THC (6 mg/kg, i.p.) impaired spatial memory in the standard task of the 8-arm radial maze. THC (4-6 mg/kg, i.p.) selectively impaired working memory in a reference and working memory task of the 8-arm radial maze. Even at a dose of 10 mg/kg, THC did not impair spatial memory in the water maze. In addition, THC at a dose of 6 mg/kg, which had inhibitory effects in the 8-arm radial maze, did not affect performance in the visual discrimination task. These results indicate that at low doses (2-6 mg/kg), THC may not produce visual function abnormalities. THC impaired retrieval (6 mg/kg, i.p.) as well as acquisition (10 mg/kg, i.p.) in the passive avoidance test. The consolidation process was also impaired by i.c.v. injection (100 microg), but not i.p. injection (6-10 mg/kg) of THC. These results suggest that THC-induced impairment of spatial memory is based on the selective impairment of working memory through its effects on acquisition and retrieval processes. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/11829149/Characteristics_of_learning_and_memory_impairment_induced_by_delta9_tetrahydrocannabinol_in_rats_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/jjp/87.297?from=PubMed DB - PRIME DP - Unbound Medicine ER -