Abstract
The impact of influenza virus infection is estimated to run into billions of dollars worldwide. Vaccination plays a key role in prevention; however, vaccines do not provide complete protection against influenza due to the constant mutation of the virus responsible. Unlike amantadine and rimantadine, which are only effective against influenza A, the new neuraminidase inhibitors zanamivir (Relenza), GlaxoSmithKline) and oseltamivir (Tamiflu), Gilead/Roche) are potent and specific inhibitors of influenza types A and B and have minimal side effects. The greatest benefit is derived if treatment commences as soon as possible after symptoms develop. In order for these inhibitors to have a significant impact on the disease, clinicians and the general public need to be made more aware of the symptoms of influenza and the availability of these new drugs.
TY - JOUR
T1 - Neuraminidase inhibitors for the treatment and prevention of influenza.
A1 - McKimm-Breschkin,Jennifer L,
PY - 2002/2/7/pubmed
PY - 2002/7/26/medline
PY - 2002/2/7/entrez
SP - 103
EP - 12
JF - Expert opinion on pharmacotherapy
JO - Expert Opin Pharmacother
VL - 3
IS - 2
N2 - The impact of influenza virus infection is estimated to run into billions of dollars worldwide. Vaccination plays a key role in prevention; however, vaccines do not provide complete protection against influenza due to the constant mutation of the virus responsible. Unlike amantadine and rimantadine, which are only effective against influenza A, the new neuraminidase inhibitors zanamivir (Relenza), GlaxoSmithKline) and oseltamivir (Tamiflu), Gilead/Roche) are potent and specific inhibitors of influenza types A and B and have minimal side effects. The greatest benefit is derived if treatment commences as soon as possible after symptoms develop. In order for these inhibitors to have a significant impact on the disease, clinicians and the general public need to be made more aware of the symptoms of influenza and the availability of these new drugs.
SN - 1465-6566
UR - https://www.unboundmedicine.com/medline/citation/11829724/Neuraminidase_inhibitors_for_the_treatment_and_prevention_of_influenza_
L2 - https://www.tandfonline.com/doi/full/10.1517/14656566.3.2.103
DB - PRIME
DP - Unbound Medicine
ER -