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[The effects of n-3 fatty acid, fructose-1, 6-diphosphate and glutamine on mucosal cell proliferation and apoptosis of small bowel graft after transplantation in rats].
Zhonghua Wai Ke Za Zhi. 1999 Jun; 37(6):375-8, 23.ZW

Abstract

OBJECTIVE

To evaluate the effects of n-3 fatty acid (n-3 FA), fructose-1, 6-diphosphate (FDP) and glutamine (GLN) on mucosal cell proliferation and apoptosis of small bowel graft.

METHODS

196 inbred strain Wistar rats underwent heterotopic small bowel transplantation (SBT) as donors and recipients respectively. n-3FA, FDP and GLN were given via gastrolavage as well as venous infusion within total parenteral nutrition (TPN) solution for 10 days before and after surgery. Flow cytometry and in situ cell death detection were used for analysing the changes of mucosal cell proliferation and apoptosis.

RESULTS

Fewer proliferation and more apoptosis took place in mucosal cells of small bowel graft after transplantation. A higher mucosal cell proliferative index and lower apoptotic index were found in all small bowel graft after supplying with n-3FA, FDP and GLN.

CONCLUSIONS

n-3FA, FDP and GLN specific nutritional support significantly promoted mucosal cell proliferation, and on the other hand inhibited mucosal cell from undergoing apoptosis with different degrees. The effects of regulation help improve the structure and absorption function of transplanted small bowel.

Authors+Show Affiliations

Institute of General Surgery, Nanjing General Hospital, People's Liberation Army, Nanjing 210002.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11829867

Citation

Wu, X, et al. "[The Effects of N-3 Fatty Acid, Fructose-1, 6-diphosphate and Glutamine On Mucosal Cell Proliferation and Apoptosis of Small Bowel Graft After Transplantation in Rats]." Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], vol. 37, no. 6, 1999, pp. 375-8, 23.
Wu X, Li J, Li N. [The effects of n-3 fatty acid, fructose-1, 6-diphosphate and glutamine on mucosal cell proliferation and apoptosis of small bowel graft after transplantation in rats]. Zhonghua Wai Ke Za Zhi. 1999;37(6):375-8, 23.
Wu, X., Li, J., & Li, N. (1999). [The effects of n-3 fatty acid, fructose-1, 6-diphosphate and glutamine on mucosal cell proliferation and apoptosis of small bowel graft after transplantation in rats]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], 37(6), 375-8, 23.
Wu X, Li J, Li N. [The Effects of N-3 Fatty Acid, Fructose-1, 6-diphosphate and Glutamine On Mucosal Cell Proliferation and Apoptosis of Small Bowel Graft After Transplantation in Rats]. Zhonghua Wai Ke Za Zhi. 1999;37(6):375-8, 23. PubMed PMID: 11829867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effects of n-3 fatty acid, fructose-1, 6-diphosphate and glutamine on mucosal cell proliferation and apoptosis of small bowel graft after transplantation in rats]. AU - Wu,X, AU - Li,J, AU - Li,N, PY - 2002/2/7/pubmed PY - 2006/3/11/medline PY - 2002/2/7/entrez SP - 375-8, 23 JF - Zhonghua wai ke za zhi [Chinese journal of surgery] JO - Zhonghua Wai Ke Za Zhi VL - 37 IS - 6 N2 - OBJECTIVE: To evaluate the effects of n-3 fatty acid (n-3 FA), fructose-1, 6-diphosphate (FDP) and glutamine (GLN) on mucosal cell proliferation and apoptosis of small bowel graft. METHODS: 196 inbred strain Wistar rats underwent heterotopic small bowel transplantation (SBT) as donors and recipients respectively. n-3FA, FDP and GLN were given via gastrolavage as well as venous infusion within total parenteral nutrition (TPN) solution for 10 days before and after surgery. Flow cytometry and in situ cell death detection were used for analysing the changes of mucosal cell proliferation and apoptosis. RESULTS: Fewer proliferation and more apoptosis took place in mucosal cells of small bowel graft after transplantation. A higher mucosal cell proliferative index and lower apoptotic index were found in all small bowel graft after supplying with n-3FA, FDP and GLN. CONCLUSIONS: n-3FA, FDP and GLN specific nutritional support significantly promoted mucosal cell proliferation, and on the other hand inhibited mucosal cell from undergoing apoptosis with different degrees. The effects of regulation help improve the structure and absorption function of transplanted small bowel. SN - 0529-5815 UR - https://www.unboundmedicine.com/medline/citation/11829867/[The_effects_of_n_3_fatty_acid_fructose_1_6_diphosphate_and_glutamine_on_mucosal_cell_proliferation_and_apoptosis_of_small_bowel_graft_after_transplantation_in_rats]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-5815&year=1999&vol=37&issue=6&fpage=375 DB - PRIME DP - Unbound Medicine ER -