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[Nutritional impact of glycyl-glutamine dipeptide on the autotransplanted small intestine in pig].
Zhonghua Wai Ke Za Zhi. 1999 Nov; 37(11):677-9.ZW

Abstract

OBJECTIVE

To observe the impact of glycyl-glutamine (Gly-Gln) dipeptide on the autotransplanted small bowel.

METHODS

Ten unbred pigs underwent small bowel autotransplantation and were divided randomly into two groups: GTPN and STPN. In the GTPN group (n = 5), the pigs received TPN supplemented with Gly-Gln for 28 days, whereas in the STPN group (n = 5), the pigs received isonitrogenous and isocaloric standard TPN for 28 days. The content of plasma glutamine (Gln), the concentrations of mucosal Gln, protein, villous DNA and RNA, villous height, mucosal thickness, crypt depth, villous surface area, D-xylose absorption test, and intestinal permeability to (99m)Tc-DTPA were measured on the operative day or on the 1st and 28th day after operation.

RESULTS

All the indexes except the intestinal permeability (IP) to (99m)Tc-DTPA were significantly higher in the GTPN group than in the STPN group (P < 0.05) on the 28th day after operation, but the IP to (99m)Tc-DTPA was significantly lower in the GTPN group than in the STPN group (P < 0.05).

CONCLUSIONS

Gly-Gln has special nutritional effect in improving the metabolism, structure and function of autotransplanted small intestine in pig.

Authors+Show Affiliations

Institute of General Surgery, Nanjing General Hospital, People's Liberation Army, Nanjing 210002.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11829925

Citation

Jiang, J, et al. "[Nutritional Impact of Glycyl-glutamine Dipeptide On the Autotransplanted Small Intestine in Pig]." Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], vol. 37, no. 11, 1999, pp. 677-9.
Jiang J, Li J, Li Y, et al. [Nutritional impact of glycyl-glutamine dipeptide on the autotransplanted small intestine in pig]. Zhonghua Wai Ke Za Zhi. 1999;37(11):677-9.
Jiang, J., Li, J., Li, Y., Wang, X., Wang, Z., & Liu, F. (1999). [Nutritional impact of glycyl-glutamine dipeptide on the autotransplanted small intestine in pig]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], 37(11), 677-9.
Jiang J, et al. [Nutritional Impact of Glycyl-glutamine Dipeptide On the Autotransplanted Small Intestine in Pig]. Zhonghua Wai Ke Za Zhi. 1999;37(11):677-9. PubMed PMID: 11829925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Nutritional impact of glycyl-glutamine dipeptide on the autotransplanted small intestine in pig]. AU - Jiang,J, AU - Li,J, AU - Li,Y, AU - Wang,X, AU - Wang,Z, AU - Liu,F, PY - 2002/2/7/pubmed PY - 2004/9/8/medline PY - 2002/2/7/entrez SP - 677 EP - 9 JF - Zhonghua wai ke za zhi [Chinese journal of surgery] JO - Zhonghua Wai Ke Za Zhi VL - 37 IS - 11 N2 - OBJECTIVE: To observe the impact of glycyl-glutamine (Gly-Gln) dipeptide on the autotransplanted small bowel. METHODS: Ten unbred pigs underwent small bowel autotransplantation and were divided randomly into two groups: GTPN and STPN. In the GTPN group (n = 5), the pigs received TPN supplemented with Gly-Gln for 28 days, whereas in the STPN group (n = 5), the pigs received isonitrogenous and isocaloric standard TPN for 28 days. The content of plasma glutamine (Gln), the concentrations of mucosal Gln, protein, villous DNA and RNA, villous height, mucosal thickness, crypt depth, villous surface area, D-xylose absorption test, and intestinal permeability to (99m)Tc-DTPA were measured on the operative day or on the 1st and 28th day after operation. RESULTS: All the indexes except the intestinal permeability (IP) to (99m)Tc-DTPA were significantly higher in the GTPN group than in the STPN group (P < 0.05) on the 28th day after operation, but the IP to (99m)Tc-DTPA was significantly lower in the GTPN group than in the STPN group (P < 0.05). CONCLUSIONS: Gly-Gln has special nutritional effect in improving the metabolism, structure and function of autotransplanted small intestine in pig. SN - 0529-5815 UR - https://www.unboundmedicine.com/medline/citation/11829925/[Nutritional_impact_of_glycyl_glutamine_dipeptide_on_the_autotransplanted_small_intestine_in_pig]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-5815&amp;year=1999&amp;vol=37&amp;issue=11&amp;fpage=677 DB - PRIME DP - Unbound Medicine ER -