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[Apolipoprotein E polymorphism in a Moroccan population: allele frequency and relation to plasma lipid concentrations].
Ann Biol Clin (Paris). 2002 Jan-Feb; 60(1):73-8.AB

Abstract

To date, no data are available on relationship between apolipoprotein E (apo E) polymorphism and lipid levels in Moroccan population. The present work reports an apo E polymorphism repartition in Moroccan population and relationship between this polymorphism and the levels of plasma cholesterol, triglycerides, apo A1, B and E. Blood samples from 168 healthy Moroccan individuals from Rabat area (90 men and 78 women), aged from 20 to 50 years (32 9 years), were analysed for serum apo E, A1 and B, triglycerides, and total cholesterol. In parallel, genotyping by means of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) was performed. The apo E allelic frequencies were 11% for epsilon4, 84% for epsilon3 and 5% for epsilon2. There were correlation between apo E alleles and serum lipid concentrations, E2/E3 carriers had significantly higher level of apo E than E3/E3, and E4/E3 carriers had significantly higher total cholesterol apo B and triglycerides than E3/E3 and E2/E3 carriers. The total cholesterol and apo B concentrations are significantly higher in women than in men but the triglycerides are lower. The apo A1 concentration is independent of both sex and apo E genotype. Thus, the results demonstrate an influence of apo E alleles on serum cholesterol, triglycerides, apo E and apo B concentrations among healthy Moroccan.

Authors+Show Affiliations

Laboratoire de biochimie, chimie, biologie et biologie moléculaire, Faculté de médecine et de pharmacie, BP 6203, Rabat Maroc.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

fre

PubMed ID

11830396

Citation

Lahlali-Kacemi, N, et al. "[Apolipoprotein E Polymorphism in a Moroccan Population: Allele Frequency and Relation to Plasma Lipid Concentrations]." Annales De Biologie Clinique, vol. 60, no. 1, 2002, pp. 73-8.
Lahlali-Kacemi N, Bamou Y, Guedira A, et al. [Apolipoprotein E polymorphism in a Moroccan population: allele frequency and relation to plasma lipid concentrations]. Ann Biol Clin (Paris). 2002;60(1):73-8.
Lahlali-Kacemi, N., Bamou, Y., Guedira, A., Hassani, M., Visvikis, S., Siest, G., Alami, N., Kabbaj, O., & Lahrichi, M. (2002). [Apolipoprotein E polymorphism in a Moroccan population: allele frequency and relation to plasma lipid concentrations]. Annales De Biologie Clinique, 60(1), 73-8.
Lahlali-Kacemi N, et al. [Apolipoprotein E Polymorphism in a Moroccan Population: Allele Frequency and Relation to Plasma Lipid Concentrations]. Ann Biol Clin (Paris). 2002 Jan-Feb;60(1):73-8. PubMed PMID: 11830396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Apolipoprotein E polymorphism in a Moroccan population: allele frequency and relation to plasma lipid concentrations]. AU - Lahlali-Kacemi,N, AU - Bamou,Y, AU - Guedira,A, AU - Hassani,M, AU - Visvikis,S, AU - Siest,G, AU - Alami,N, AU - Kabbaj,O, AU - Lahrichi,M, PY - 2002/2/7/pubmed PY - 2002/9/6/medline PY - 2002/2/7/entrez SP - 73 EP - 8 JF - Annales de biologie clinique JO - Ann Biol Clin (Paris) VL - 60 IS - 1 N2 - To date, no data are available on relationship between apolipoprotein E (apo E) polymorphism and lipid levels in Moroccan population. The present work reports an apo E polymorphism repartition in Moroccan population and relationship between this polymorphism and the levels of plasma cholesterol, triglycerides, apo A1, B and E. Blood samples from 168 healthy Moroccan individuals from Rabat area (90 men and 78 women), aged from 20 to 50 years (32 9 years), were analysed for serum apo E, A1 and B, triglycerides, and total cholesterol. In parallel, genotyping by means of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) was performed. The apo E allelic frequencies were 11% for epsilon4, 84% for epsilon3 and 5% for epsilon2. There were correlation between apo E alleles and serum lipid concentrations, E2/E3 carriers had significantly higher level of apo E than E3/E3, and E4/E3 carriers had significantly higher total cholesterol apo B and triglycerides than E3/E3 and E2/E3 carriers. The total cholesterol and apo B concentrations are significantly higher in women than in men but the triglycerides are lower. The apo A1 concentration is independent of both sex and apo E genotype. Thus, the results demonstrate an influence of apo E alleles on serum cholesterol, triglycerides, apo E and apo B concentrations among healthy Moroccan. SN - 0003-3898 UR - https://www.unboundmedicine.com/medline/citation/11830396/[Apolipoprotein_E_polymorphism_in_a_Moroccan_population:_allele_frequency_and_relation_to_plasma_lipid_concentrations]_ L2 - http://www.jle.com/medline.md?issn=0003-3898&vol=60&iss=1&page=73 DB - PRIME DP - Unbound Medicine ER -