Tags

Type your tag names separated by a space and hit enter

Positive association of ankylosing spondylitis with homozygous HLA-B2704, but protection with B2705 in Taiwan Chinese.
Kaohsiung J Med Sci. 2001 Oct; 17(10):509-16.KJ

Abstract

The study was undertaken to determine the effects of HLA-B27 subtypes on susceptibility to ankylosing spondylitis (AS) in Taiwan Chinese, a polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method was developed for subtyping of HLA-B27. In this series, there are 62 patients with AS who were tested HLA-B27 positive serologically and 738 normal persons over the age of 65. Among the 738 normal controls, 42 (5.7%) were HLA-B27 positive. There were six (14.3%) homozygous for B2704, 18 (42.9%) heterozygous for B2704, 2 (4.8%) double heterozygous for B2704 and B2705, one (2.3%) double heterozygous for B2704 and B2706, 2 (4.8%) homozygous for B2705, 11 (26.1%) heterozygous for B2705, and 2 (4.8%) heterozygous for B2706. In our patients with AS, 37 (59.7%) were homozygous for B2704 and 25 (40.3%) were heterozygous for B2704. The HLA-B27 carrier rate in Taiwan healthy old persons is estimated at 5.7%. Susceptibility to AS is determined by homozygosity for B2704. However, B2705 may be an indicator of protection against AS in Taiwan Chinese.

Authors+Show Affiliations

Shih HC
Department of Laboratory Medicine, China Medical College Hospital, Taichung, Taiwan.
Liu SC
No affiliation info available
Chang CP
No affiliation info available
Tschen JS
No affiliation info available
Chiu HY
No affiliation info available
Liu HC
No affiliation info available
Chang JG
No affiliation info available

MeSH

AgedAllelesGenetic Predisposition to DiseaseHLA-B27 AntigenHomozygoteHumansSpondylitis, AnkylosingTaiwan

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11831114

Citation

Shih, H C., et al. "Positive Association of Ankylosing Spondylitis With Homozygous HLA-B2704, but Protection With B2705 in Taiwan Chinese." The Kaohsiung Journal of Medical Sciences, vol. 17, no. 10, 2001, pp. 509-16.
Shih HC, Liu SC, Chang CP, et al. Positive association of ankylosing spondylitis with homozygous HLA-B2704, but protection with B2705 in Taiwan Chinese. Kaohsiung J Med Sci. 2001;17(10):509-16.
Shih, H. C., Liu, S. C., Chang, C. P., Tschen, J. S., Chiu, H. Y., Liu, H. C., & Chang, J. G. (2001). Positive association of ankylosing spondylitis with homozygous HLA-B2704, but protection with B2705 in Taiwan Chinese. The Kaohsiung Journal of Medical Sciences, 17(10), 509-16.
Shih HC, et al. Positive Association of Ankylosing Spondylitis With Homozygous HLA-B2704, but Protection With B2705 in Taiwan Chinese. Kaohsiung J Med Sci. 2001;17(10):509-16. PubMed PMID: 11831114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Positive association of ankylosing spondylitis with homozygous HLA-B2704, but protection with B2705 in Taiwan Chinese. AU - Shih,H C, AU - Liu,S C, AU - Chang,C P, AU - Tschen,J S, AU - Chiu,H Y, AU - Liu,H C, AU - Chang,J G, PY - 2002/2/8/pubmed PY - 2002/3/1/medline PY - 2002/2/8/entrez SP - 509 EP - 16 JF - The Kaohsiung journal of medical sciences JO - Kaohsiung J Med Sci VL - 17 IS - 10 N2 - The study was undertaken to determine the effects of HLA-B27 subtypes on susceptibility to ankylosing spondylitis (AS) in Taiwan Chinese, a polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method was developed for subtyping of HLA-B27. In this series, there are 62 patients with AS who were tested HLA-B27 positive serologically and 738 normal persons over the age of 65. Among the 738 normal controls, 42 (5.7%) were HLA-B27 positive. There were six (14.3%) homozygous for B2704, 18 (42.9%) heterozygous for B2704, 2 (4.8%) double heterozygous for B2704 and B2705, one (2.3%) double heterozygous for B2704 and B2706, 2 (4.8%) homozygous for B2705, 11 (26.1%) heterozygous for B2705, and 2 (4.8%) heterozygous for B2706. In our patients with AS, 37 (59.7%) were homozygous for B2704 and 25 (40.3%) were heterozygous for B2704. The HLA-B27 carrier rate in Taiwan healthy old persons is estimated at 5.7%. Susceptibility to AS is determined by homozygosity for B2704. However, B2705 may be an indicator of protection against AS in Taiwan Chinese. SN - 1607-551X UR - https://www.unboundmedicine.com/medline/citation/11831114/Positive_association_of_ankylosing_spondylitis_with_homozygous_HLA_B2704_but_protection_with_B2705_in_Taiwan_Chinese_ L2 - https://www.diseaseinfosearch.org/result/9679 DB - PRIME DP - Unbound Medicine ER -