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[Improvement of protein metabolism by glutamine-enriched TPN and growth hormone in recipients of rat small bowel transplantation].
Zhonghua Wai Ke Za Zhi. 2000 Aug; 38(8):622-4.ZW

Abstract

OBJECTIVE

To observe the effect of glutamine-enriched TPN and recombinant human growth hormone (rhGH)on protein metabolism of recipient of rat small bowel transplantation.

METHODS

Twenty four recipients of rat allogeneic heterotopic small bowel transplantation (SD-->Wistar rat) were divided into 4 groups randomly according to the presence or absence of glutamine or rhGH in TPN regimen. Cyclosporine A (CsA) was used as the immunosuppressant. The changes of body weight, nitrogen balance, urinary 3-methyl histidine excretion and plasma albumin level during 14 days after transplantation were observed.

RESULTS

Applications of glutamine-enriched TPN or rhGH decreased the postoperative catabolism of protein of recipients. They promoted protein synthesis and positive nitrogen balance so as to minimize the loss of body weight and correct hypoalbuminemia. They were synergistic to other.

CONCLUSIONS

Glutamine-enriched TPN and rhGH can promote the protein metabolism of rat small bowel transplantation recipients effectively with the use of CsA, so as to improve the recovery of general condition. Their combination may have the synergistic effect.

Authors+Show Affiliations

Team of Graduate Student, Second Military Medical University, People's Liberation Army, Shanghai 200433, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11832125

Citation

Zhang, X, et al. "[Improvement of Protein Metabolism By Glutamine-enriched TPN and Growth Hormone in Recipients of Rat Small Bowel Transplantation]." Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], vol. 38, no. 8, 2000, pp. 622-4.
Zhang X, Li J, Li N, et al. [Improvement of protein metabolism by glutamine-enriched TPN and growth hormone in recipients of rat small bowel transplantation]. Zhonghua Wai Ke Za Zhi. 2000;38(8):622-4.
Zhang, X., Li, J., Li, N., & Li, Y. (2000). [Improvement of protein metabolism by glutamine-enriched TPN and growth hormone in recipients of rat small bowel transplantation]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], 38(8), 622-4.
Zhang X, et al. [Improvement of Protein Metabolism By Glutamine-enriched TPN and Growth Hormone in Recipients of Rat Small Bowel Transplantation]. Zhonghua Wai Ke Za Zhi. 2000;38(8):622-4. PubMed PMID: 11832125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Improvement of protein metabolism by glutamine-enriched TPN and growth hormone in recipients of rat small bowel transplantation]. AU - Zhang,X, AU - Li,J, AU - Li,N, AU - Li,Y, PY - 2002/2/8/pubmed PY - 2005/1/15/medline PY - 2002/2/8/entrez SP - 622 EP - 4 JF - Zhonghua wai ke za zhi [Chinese journal of surgery] JO - Zhonghua Wai Ke Za Zhi VL - 38 IS - 8 N2 - OBJECTIVE: To observe the effect of glutamine-enriched TPN and recombinant human growth hormone (rhGH)on protein metabolism of recipient of rat small bowel transplantation. METHODS: Twenty four recipients of rat allogeneic heterotopic small bowel transplantation (SD-->Wistar rat) were divided into 4 groups randomly according to the presence or absence of glutamine or rhGH in TPN regimen. Cyclosporine A (CsA) was used as the immunosuppressant. The changes of body weight, nitrogen balance, urinary 3-methyl histidine excretion and plasma albumin level during 14 days after transplantation were observed. RESULTS: Applications of glutamine-enriched TPN or rhGH decreased the postoperative catabolism of protein of recipients. They promoted protein synthesis and positive nitrogen balance so as to minimize the loss of body weight and correct hypoalbuminemia. They were synergistic to other. CONCLUSIONS: Glutamine-enriched TPN and rhGH can promote the protein metabolism of rat small bowel transplantation recipients effectively with the use of CsA, so as to improve the recovery of general condition. Their combination may have the synergistic effect. SN - 0529-5815 UR - https://www.unboundmedicine.com/medline/citation/11832125/[Improvement_of_protein_metabolism_by_glutamine_enriched_TPN_and_growth_hormone_in_recipients_of_rat_small_bowel_transplantation]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-5815&year=2000&vol=38&issue=8&fpage=622 DB - PRIME DP - Unbound Medicine ER -