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[Usefulness of olanzapine in the levodopa-induced psychosis in patients with Parkinson's disease].
Neurologia. 2002 Jan; 17(1):7-11.N

Abstract

BACKGROUND

To evaluate the antipsychotic efficacy of olanzapine (OLZ) in patients with Parkinson's disease (PD) and drug-induced psychosis (DIP) and its repercussion on the motor function.

METHODS

Ten patients (5 women and 5 men) diagnosed of PD and DIP, aged 67 years (range: 50-81), with PD duration of 11.1 years (range: 6-23), treated chronically with levodopa per day, received a dose of 2.5 or 5.0 mg OLZ daily. Data concerning improvement of psychosis and worsening of motor function was based on Positive And Negative Symptoms Scale (PANSS) and Unified Parkinsons Disease Rating Scale (UPDRS) motor.

RESULTS

Psychotic symptoms were improved in all patients. In most of them the improvement was almost total. Seven patients increased levodopa dose on OLZ, but significant worsening of motor function was reported just in one patient. None of the patients had agranulocytosis in the blood monitoring. Two patients presented weight gain. Seven patients improved their cognitive status.

CONCLUSIONS

We conclude that OLZ at the doses studied may have efficacy for DIP which appears in PD and does not induce worsening of motor function in most of the patients.

Authors+Show Affiliations

Servicios de Neurología, Hospital Universitario Virgen Macarena, Sevilla, Spain. jchaconp@supercable.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

spa

PubMed ID

11834192

Citation

Chacón, J R., et al. "[Usefulness of Olanzapine in the Levodopa-induced Psychosis in Patients With Parkinson's Disease]." Neurologia (Barcelona, Spain), vol. 17, no. 1, 2002, pp. 7-11.
Chacón JR, Durán E, Durán JA, et al. [Usefulness of olanzapine in the levodopa-induced psychosis in patients with Parkinson's disease]. Neurologia. 2002;17(1):7-11.
Chacón, J. R., Durán, E., Durán, J. A., & Alvarez, M. (2002). [Usefulness of olanzapine in the levodopa-induced psychosis in patients with Parkinson's disease]. Neurologia (Barcelona, Spain), 17(1), 7-11.
Chacón JR, et al. [Usefulness of Olanzapine in the Levodopa-induced Psychosis in Patients With Parkinson's Disease]. Neurologia. 2002;17(1):7-11. PubMed PMID: 11834192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Usefulness of olanzapine in the levodopa-induced psychosis in patients with Parkinson's disease]. AU - Chacón,J R, AU - Durán,E, AU - Durán,J A, AU - Alvarez,M, PY - 2002/2/9/pubmed PY - 2002/4/19/medline PY - 2002/2/9/entrez SP - 7 EP - 11 JF - Neurologia (Barcelona, Spain) JO - Neurologia VL - 17 IS - 1 N2 - BACKGROUND: To evaluate the antipsychotic efficacy of olanzapine (OLZ) in patients with Parkinson's disease (PD) and drug-induced psychosis (DIP) and its repercussion on the motor function. METHODS: Ten patients (5 women and 5 men) diagnosed of PD and DIP, aged 67 years (range: 50-81), with PD duration of 11.1 years (range: 6-23), treated chronically with levodopa per day, received a dose of 2.5 or 5.0 mg OLZ daily. Data concerning improvement of psychosis and worsening of motor function was based on Positive And Negative Symptoms Scale (PANSS) and Unified Parkinsons Disease Rating Scale (UPDRS) motor. RESULTS: Psychotic symptoms were improved in all patients. In most of them the improvement was almost total. Seven patients increased levodopa dose on OLZ, but significant worsening of motor function was reported just in one patient. None of the patients had agranulocytosis in the blood monitoring. Two patients presented weight gain. Seven patients improved their cognitive status. CONCLUSIONS: We conclude that OLZ at the doses studied may have efficacy for DIP which appears in PD and does not induce worsening of motor function in most of the patients. SN - 0213-4853 UR - https://www.unboundmedicine.com/medline/citation/11834192/[Usefulness_of_olanzapine_in_the_levodopa_induced_psychosis_in_patients_with_Parkinson's_disease]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -