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Increased intima-media thickness in familial combined hyperlipidemia associated with apolipoprotein B.
Arterioscler Thromb Vasc Biol 2002; 22(2):283-8AT

Abstract

The aim of the present study was to quantify intima-media thickness (IMT) in familial combined hyperlipidemia (FCHL) and to evaluate the relationship of IMT in FCHL-affected subjects with lipids and apolipoproteins, blood pressure values, and surrogate markers of insulin resistance. IMT was measured by ultrasound at the left and right common carotid arteries in 46 FCHL-affected subjects who were free of clinical manifestations of atherosclerosis and in 55 age- and sex-matched healthy control subjects. FCHL-affected subjects had significantly increased IMT compared with healthy control subjects, with a difference of 57 microm (age- and sex-corrected P<0.01). In the FCHL group, significantly positive age- and sex-corrected univariate correlations were observed between IMT and total cholesterol, non-high density lipoprotein cholesterol, and apolipoprotein B. Multivariate regression analyses revealed that age, sex, and apolipoprotein B were significant and independent predictors of IMT, whereas body mass index was of borderline significance. Combined, these factors explained almost 50% of the observed IMT variation (P<0.001). The increased IMT observed in FCHL corresponds with approximately 7 years of physiological IMT increase in excess of the average IMT in age- and sex-matched control subjects. These novel findings show the important relationship between lipoprotein particles, marked by increased apolipoprotein B concentrations, and an increased IMT in FCHL. The increased IMT in FCHL-affected subjects is in agreement with the known high risk of cardiovascular disease in FCHL.

Authors+Show Affiliations

University Hospital Maastricht, Department of Medicine, Cardiovascular Research Institute Maastricht, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11834529

Citation

Keulen, Eric T P., et al. "Increased Intima-media Thickness in Familial Combined Hyperlipidemia Associated With Apolipoprotein B." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 2, 2002, pp. 283-8.
Keulen ET, Kruijshoop M, Schaper NC, et al. Increased intima-media thickness in familial combined hyperlipidemia associated with apolipoprotein B. Arterioscler Thromb Vasc Biol. 2002;22(2):283-8.
Keulen, E. T., Kruijshoop, M., Schaper, N. C., Hoeks, A. P., & de Bruin, T. W. (2002). Increased intima-media thickness in familial combined hyperlipidemia associated with apolipoprotein B. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(2), pp. 283-8.
Keulen ET, et al. Increased Intima-media Thickness in Familial Combined Hyperlipidemia Associated With Apolipoprotein B. Arterioscler Thromb Vasc Biol. 2002 Feb 1;22(2):283-8. PubMed PMID: 11834529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased intima-media thickness in familial combined hyperlipidemia associated with apolipoprotein B. AU - Keulen,Eric T P, AU - Kruijshoop,Margriet, AU - Schaper,Nicolaas C, AU - Hoeks,Arnold P G, AU - de Bruin,Tjerk W A, PY - 2002/2/9/pubmed PY - 2002/2/22/medline PY - 2002/2/9/entrez SP - 283 EP - 8 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 22 IS - 2 N2 - The aim of the present study was to quantify intima-media thickness (IMT) in familial combined hyperlipidemia (FCHL) and to evaluate the relationship of IMT in FCHL-affected subjects with lipids and apolipoproteins, blood pressure values, and surrogate markers of insulin resistance. IMT was measured by ultrasound at the left and right common carotid arteries in 46 FCHL-affected subjects who were free of clinical manifestations of atherosclerosis and in 55 age- and sex-matched healthy control subjects. FCHL-affected subjects had significantly increased IMT compared with healthy control subjects, with a difference of 57 microm (age- and sex-corrected P<0.01). In the FCHL group, significantly positive age- and sex-corrected univariate correlations were observed between IMT and total cholesterol, non-high density lipoprotein cholesterol, and apolipoprotein B. Multivariate regression analyses revealed that age, sex, and apolipoprotein B were significant and independent predictors of IMT, whereas body mass index was of borderline significance. Combined, these factors explained almost 50% of the observed IMT variation (P<0.001). The increased IMT observed in FCHL corresponds with approximately 7 years of physiological IMT increase in excess of the average IMT in age- and sex-matched control subjects. These novel findings show the important relationship between lipoprotein particles, marked by increased apolipoprotein B concentrations, and an increased IMT in FCHL. The increased IMT in FCHL-affected subjects is in agreement with the known high risk of cardiovascular disease in FCHL. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/11834529/Increased_intima_media_thickness_in_familial_combined_hyperlipidemia_associated_with_apolipoprotein_B_ L2 - http://www.ahajournals.org/doi/full/10.1161/hq0202.104100?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -