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Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis.
In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age- and sex-matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non-transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect.
Department of Haematology, City Hospital Trust, Birmingham, United Kingdom. email@example.com, , , ,
Anemia, Sickle Cell
Pub Type(s)Journal Article