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Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis.

Abstract

In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age- and sex-matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non-transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect.

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  • Authors

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    Source

    American journal of hematology 69:2 2002 Feb pg 144-6

    MeSH

    Adult
    Anemia, Sickle Cell
    Antioxidants
    Blood Transfusion
    Female
    Humans
    Iron Overload
    Male
    Oxidative Stress
    Vitamin E

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11835354

    Citation

    TY - JOUR T1 - Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis. AU - Marwah,S S, AU - Blann,A D, AU - Rea,C, AU - Phillips,J D, AU - Wright,J, AU - Bareford,D, PY - 2002/2/9/pubmed PY - 2002/2/22/medline PY - 2002/2/9/entrez SP - 144 EP - 6 JF - American journal of hematology JO - Am. J. Hematol. VL - 69 IS - 2 N2 - In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age- and sex-matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non-transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/11835354/full_citation L2 - http://dx.doi.org/10.1002/ajh.10033 ER -