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Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis.
Am J Hematol. 2002 Feb; 69(2):144-6.AJ

Abstract

In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age- and sex-matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non-transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect.

Authors+Show Affiliations

Marwah SS
Department of Haematology, City Hospital Trust, Birmingham, United Kingdom. sukhjinder.marwah@cityhospbham.wmids.nhs.uk
Blann AD
No affiliation info available
Rea C
No affiliation info available
Phillips JD
No affiliation info available
Wright J
No affiliation info available
Bareford D
No affiliation info available

MeSH

AdultAnemia, Sickle CellAntioxidantsBlood TransfusionFemaleHumansIron OverloadMaleOxidative StressTransfusion ReactionVitamin E

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11835354

Citation

Marwah, S S., et al. "Reduced Vitamin E Antioxidant Capacity in Sickle Cell Disease Is Related to Transfusion Status but Not to Sickle Crisis." American Journal of Hematology, vol. 69, no. 2, 2002, pp. 144-6.
Marwah SS, Blann AD, Rea C, et al. Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis. Am J Hematol. 2002;69(2):144-6.
Marwah, S. S., Blann, A. D., Rea, C., Phillips, J. D., Wright, J., & Bareford, D. (2002). Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis. American Journal of Hematology, 69(2), 144-6.
Marwah SS, et al. Reduced Vitamin E Antioxidant Capacity in Sickle Cell Disease Is Related to Transfusion Status but Not to Sickle Crisis. Am J Hematol. 2002;69(2):144-6. PubMed PMID: 11835354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis. AU - Marwah,S S, AU - Blann,A D, AU - Rea,C, AU - Phillips,J D, AU - Wright,J, AU - Bareford,D, PY - 2002/2/9/pubmed PY - 2002/2/22/medline PY - 2002/2/9/entrez SP - 144 EP - 6 JF - American journal of hematology JO - Am J Hematol VL - 69 IS - 2 N2 - In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age- and sex-matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non-transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/11835354/full_citation L2 - https://doi.org/10.1002/ajh.10033 DB - PRIME DP - Unbound Medicine ER -