Tags

Type your tag names separated by a space and hit enter

Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease.

Abstract

Abnormally phosphorylated tau accumulates as neurofibrillary tangles and neuropil threads in older persons with and without Alzheimer's disease. The relationship between neurofibrillary tangles and neuropil threads and how they relate to cognitive function is unknown. This study investigated the relationship between phosphorylated tau lesions and cognitive function in 31 persons participating in the Religious Orders Study, a prospective, longitudinal clinicopathological study of aging and Alzheimer's disease. All subjects underwent detailed neuropsychological performance testing within a year of death and evidenced a spectrum of cognitive performance ranging from normal abilities to mild dementia. Measures of neurofibrillary tangle density and phosphorylated tau immunoreactive structures (predominantly neuropil threads) in the entorhinal and perirhinal cortices by quantitative image analysis were significantly correlated (r = 0.5). In multiple linear regression analyses controlling for age, sex, and education, parahippocampal neurofibrillary tangles and neuropil threads were significantly lower in persons without cognitive impairment compared to those with mild cognitive impairment and/or Alzheimer's disease. Further, neurofibrillary tangles were significantly correlated to measures of episodic memory but not other cognitive abilities; neuropil tangles were not significantly related to memory or other cognitive functions. These data indicate that phosphorylated tau pathology in the ventromedial temporal lobe develop prior to the onset of clinical dementia and their presence is associated with cognitive impairment, particularly impairment of episodic memory.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

    , , , , , , , , ,

    Source

    Annals of neurology 51:2 2002 Feb pg 182-9

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    Cognition Disorders
    Female
    Humans
    Linear Models
    Longitudinal Studies
    Male
    Neurofibrillary Tangles
    Parahippocampal Gyrus
    Prospective Studies
    tau Proteins

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11835374

    Citation

    Mitchell, Thomas W., et al. "Parahippocampal Tau Pathology in Healthy Aging, Mild Cognitive Impairment, and Early Alzheimer's Disease." Annals of Neurology, vol. 51, no. 2, 2002, pp. 182-9.
    Mitchell TW, Mufson EJ, Schneider JA, et al. Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Ann Neurol. 2002;51(2):182-9.
    Mitchell, T. W., Mufson, E. J., Schneider, J. A., Cochran, E. J., Nissanov, J., Han, L. Y., ... Arnold, S. E. (2002). Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Annals of Neurology, 51(2), pp. 182-9.
    Mitchell TW, et al. Parahippocampal Tau Pathology in Healthy Aging, Mild Cognitive Impairment, and Early Alzheimer's Disease. Ann Neurol. 2002;51(2):182-9. PubMed PMID: 11835374.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. AU - Mitchell,Thomas W, AU - Mufson,Elliott J, AU - Schneider,Julie A, AU - Cochran,Elizabeth J, AU - Nissanov,Jonathan, AU - Han,Li-Ying, AU - Bienias,Julia L, AU - Lee,Virginia M -Y, AU - Trojanowski,John Q, AU - Bennett,David A, AU - Arnold,Steven E, PY - 2002/2/9/pubmed PY - 2002/3/2/medline PY - 2002/2/9/entrez SP - 182 EP - 9 JF - Annals of neurology JO - Ann. Neurol. VL - 51 IS - 2 N2 - Abnormally phosphorylated tau accumulates as neurofibrillary tangles and neuropil threads in older persons with and without Alzheimer's disease. The relationship between neurofibrillary tangles and neuropil threads and how they relate to cognitive function is unknown. This study investigated the relationship between phosphorylated tau lesions and cognitive function in 31 persons participating in the Religious Orders Study, a prospective, longitudinal clinicopathological study of aging and Alzheimer's disease. All subjects underwent detailed neuropsychological performance testing within a year of death and evidenced a spectrum of cognitive performance ranging from normal abilities to mild dementia. Measures of neurofibrillary tangle density and phosphorylated tau immunoreactive structures (predominantly neuropil threads) in the entorhinal and perirhinal cortices by quantitative image analysis were significantly correlated (r = 0.5). In multiple linear regression analyses controlling for age, sex, and education, parahippocampal neurofibrillary tangles and neuropil threads were significantly lower in persons without cognitive impairment compared to those with mild cognitive impairment and/or Alzheimer's disease. Further, neurofibrillary tangles were significantly correlated to measures of episodic memory but not other cognitive abilities; neuropil tangles were not significantly related to memory or other cognitive functions. These data indicate that phosphorylated tau pathology in the ventromedial temporal lobe develop prior to the onset of clinical dementia and their presence is associated with cognitive impairment, particularly impairment of episodic memory. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/11835374/Parahippocampal_tau_pathology_in_healthy_aging_mild_cognitive_impairment_and_early_Alzheimer's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2002&volume=51&issue=2&spage=182 DB - PRIME DP - Unbound Medicine ER -