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Lower birth-weight in neonates of mothers carrying factor V G1691A and factor II A(20210) mutations.
Haematologica. 2002 Feb; 87(2):177-81.H

Abstract

BACKGROUND AND OBJECTIVES

Inherited thrombophilia has been associated with fetal and maternal complications of pregnancy. It is reasonable to suppose that an imbalance of maternal hemostasis could lead to decreased fetal growth.

DESIGN AND METHODS

We retrospectively investigated the birth-weight of neonates in relation to the presence of factor V G1691A and factor II A(20210) mutations in the mothers. Overall, 755 women (194 with a history of unexplained recurrent pregnancy loss, 202 with gestational hypertension with or without proteinuria, 359 with at least one uneventful pregnancy) and 1100 alive neonates were considered.

RESULTS

Among 980 neonates from mothers without mutations, 136 (13.9%) weighed <2500 grams, whereas 34 out 123 (27.6%) neonates from mothers carrying the factor V G1691A or factor II A(20210) mutation were under this birth-weight (OR: 2.4, 95%CI: 1.5- 3.7). Adjusting for diagnosis, parity, and age, the risk of having a baby <2500 grams was 2.0 (95%CI: 1.1-3.6) in women carrying factor V G1691A or factor II A(20210) mutation. When we analyzed all the neonates according to growth centiles and the presence of a thrombophilic mutation in the mothers, we found 142 (14.5%) and 28 (22.8%) neonates under the 10th centile from mothers without and with thrombophilic mutations, respectively (OR: 1.7, 95%-CI: 1.1-2.7). Adjusting for confounding variables (diagnosis, parity and age), the association between thrombophilic mutations and <10th growth centile did not change (OR: 1.7, 95% CI: 1.0-3.0).

INTERPRETATION AND CONCLUSIONS

Mothers carrying the factor V G1691A or factor II A(20210) mutation have a significantly higher risk of delivering neonates with a lower birth-weight.

Authors+Show Affiliations

Unità di Aterosclerosi e Trombosi and Obstetrics, Gynecology Department, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy. grandone@katamail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11836168

Citation

Grandone, Elvira, et al. "Lower Birth-weight in Neonates of Mothers Carrying Factor V G1691A and Factor II A(20210) Mutations." Haematologica, vol. 87, no. 2, 2002, pp. 177-81.
Grandone E, Margaglione M, Colaizzo D, et al. Lower birth-weight in neonates of mothers carrying factor V G1691A and factor II A(20210) mutations. Haematologica. 2002;87(2):177-81.
Grandone, E., Margaglione, M., Colaizzo, D., Pavone, G., Paladini, D., Martinelli, P., & Di Minno, G. (2002). Lower birth-weight in neonates of mothers carrying factor V G1691A and factor II A(20210) mutations. Haematologica, 87(2), 177-81.
Grandone E, et al. Lower Birth-weight in Neonates of Mothers Carrying Factor V G1691A and Factor II A(20210) Mutations. Haematologica. 2002;87(2):177-81. PubMed PMID: 11836168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower birth-weight in neonates of mothers carrying factor V G1691A and factor II A(20210) mutations. AU - Grandone,Elvira, AU - Margaglione,Maurizio, AU - Colaizzo,Donatella, AU - Pavone,Giuseppe, AU - Paladini,Dario, AU - Martinelli,Pasquale, AU - Di Minno,Giovanni, PY - 2002/2/12/pubmed PY - 2002/4/16/medline PY - 2002/2/12/entrez SP - 177 EP - 81 JF - Haematologica JO - Haematologica VL - 87 IS - 2 N2 - BACKGROUND AND OBJECTIVES: Inherited thrombophilia has been associated with fetal and maternal complications of pregnancy. It is reasonable to suppose that an imbalance of maternal hemostasis could lead to decreased fetal growth. DESIGN AND METHODS: We retrospectively investigated the birth-weight of neonates in relation to the presence of factor V G1691A and factor II A(20210) mutations in the mothers. Overall, 755 women (194 with a history of unexplained recurrent pregnancy loss, 202 with gestational hypertension with or without proteinuria, 359 with at least one uneventful pregnancy) and 1100 alive neonates were considered. RESULTS: Among 980 neonates from mothers without mutations, 136 (13.9%) weighed <2500 grams, whereas 34 out 123 (27.6%) neonates from mothers carrying the factor V G1691A or factor II A(20210) mutation were under this birth-weight (OR: 2.4, 95%CI: 1.5- 3.7). Adjusting for diagnosis, parity, and age, the risk of having a baby <2500 grams was 2.0 (95%CI: 1.1-3.6) in women carrying factor V G1691A or factor II A(20210) mutation. When we analyzed all the neonates according to growth centiles and the presence of a thrombophilic mutation in the mothers, we found 142 (14.5%) and 28 (22.8%) neonates under the 10th centile from mothers without and with thrombophilic mutations, respectively (OR: 1.7, 95%-CI: 1.1-2.7). Adjusting for confounding variables (diagnosis, parity and age), the association between thrombophilic mutations and <10th growth centile did not change (OR: 1.7, 95% CI: 1.0-3.0). INTERPRETATION AND CONCLUSIONS: Mothers carrying the factor V G1691A or factor II A(20210) mutation have a significantly higher risk of delivering neonates with a lower birth-weight. SN - 0390-6078 UR - https://www.unboundmedicine.com/medline/citation/11836168/Lower_birth_weight_in_neonates_of_mothers_carrying_factor_V_G1691A_and_factor_II_A_20210__mutations_ L2 - https://biocyc.org/gene?orgid=HUMAN&amp;id=HS11470 DB - PRIME DP - Unbound Medicine ER -