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Report of two cases with Van der Woude syndrome: a child and her mother.
Genet Couns. 2001; 12(4):341-6.GC

Abstract

Report of two cases with Van der Woude syndrome: a child and her mother: Congenital pits of the lower lip are rare malformations. They are closely associated with cleft lip (CL), cleft lip/palate (CL/CP) or isolated cleft palate (CP) and if so this condition is known as Van der Woude syndrome, which is inherited in an autosomal dominant fashion with high penetrance. Two individuals, one with lower lip pits and cleft palate and the other with isolated lower lip pit from the same family are described. Autosomal dominant pattern of inheritance was observed in this family and treatment consisted of complete removal of sinus tracts in one patient. Pathological features of sinus tracts consisted of stratified nonkeratinized squamous epithelium and a lamina propria of dense connective tissue. Importance of genetic counseling is emphasized as at least half of gene carriers have some kind of clefting.

Authors+Show Affiliations

Plastic and Reconstructive Surgery Clinic, Ankara Training and Research Hospital, Turkey. u.kocer@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11837602

Citation

Koçer, U, et al. "Report of Two Cases With Van Der Woude Syndrome: a Child and Her Mother." Genetic Counseling (Geneva, Switzerland), vol. 12, no. 4, 2001, pp. 341-6.
Koçer U, Aksoy HM, Tiftikcioğlu YO, et al. Report of two cases with Van der Woude syndrome: a child and her mother. Genet Couns. 2001;12(4):341-6.
Koçer, U., Aksoy, H. M., Tiftikcioğlu, Y. O., Cöloğlu, H., & Karaaslan, O. (2001). Report of two cases with Van der Woude syndrome: a child and her mother. Genetic Counseling (Geneva, Switzerland), 12(4), 341-6.
Koçer U, et al. Report of Two Cases With Van Der Woude Syndrome: a Child and Her Mother. Genet Couns. 2001;12(4):341-6. PubMed PMID: 11837602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Report of two cases with Van der Woude syndrome: a child and her mother. AU - Koçer,U, AU - Aksoy,H M, AU - Tiftikcioğlu,Y O, AU - Cöloğlu,H, AU - Karaaslan,O, PY - 2002/2/12/pubmed PY - 2002/7/24/medline PY - 2002/2/12/entrez SP - 341 EP - 6 JF - Genetic counseling (Geneva, Switzerland) JO - Genet. Couns. VL - 12 IS - 4 N2 - Report of two cases with Van der Woude syndrome: a child and her mother: Congenital pits of the lower lip are rare malformations. They are closely associated with cleft lip (CL), cleft lip/palate (CL/CP) or isolated cleft palate (CP) and if so this condition is known as Van der Woude syndrome, which is inherited in an autosomal dominant fashion with high penetrance. Two individuals, one with lower lip pits and cleft palate and the other with isolated lower lip pit from the same family are described. Autosomal dominant pattern of inheritance was observed in this family and treatment consisted of complete removal of sinus tracts in one patient. Pathological features of sinus tracts consisted of stratified nonkeratinized squamous epithelium and a lamina propria of dense connective tissue. Importance of genetic counseling is emphasized as at least half of gene carriers have some kind of clefting. SN - 1015-8146 UR - https://www.unboundmedicine.com/medline/citation/11837602/Report_of_two_cases_with_Van_der_Woude_syndrome:_a_child_and_her_mother_ L2 - http://www.diseaseinfosearch.org/result/1331 DB - PRIME DP - Unbound Medicine ER -