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Eradication of residual bcr-abl-positive clones by inducing graft-versus-host disease after allogeneic stem cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Bone Marrow Transplant. 2002 Jan; 29(1):63-6.BM

Abstract

Persistence of bcr-abl transcripts after marrow grafting is thought to convey a high risk for relapse in patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). Donor leukocyte infusion (DLI) is closely associated with development of graft-versus-host disease (GVHD) and has well-defined activity against relapsed chronic myelogenous leukemia (CML) but not ALL. We report two patients with Ph-positive ALL who remained bcr-abl positive by reverse transcriptase polymerase chain reaction (RT-PCR) after marrow grafting. Residual bcr-abl transcripts in both patients were eliminated following acute GVHD, which was induced by either DLI or rapid reduction of immunosuppression. Both patients have continued in complete molecular remission for 18 months and 8 months following transplantation, respectively. Our observation suggests that induction of GVHD may eliminate minimal residual disease, thereby preventing leukemia relapse in patients transplanted for Ph-positive ALL.

Authors+Show Affiliations

Division of Hematology/Oncology, Department of Medicine, Kameda General Hospital, Kamogawa, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11840146

Citation

Matsue, K, et al. "Eradication of Residual Bcr-abl-positive Clones By Inducing Graft-versus-host Disease After Allogeneic Stem Cell Transplantation in Patients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia." Bone Marrow Transplantation, vol. 29, no. 1, 2002, pp. 63-6.
Matsue K, Tabayashi T, Yamada K, et al. Eradication of residual bcr-abl-positive clones by inducing graft-versus-host disease after allogeneic stem cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant. 2002;29(1):63-6.
Matsue, K., Tabayashi, T., Yamada, K., & Takeuchi, M. (2002). Eradication of residual bcr-abl-positive clones by inducing graft-versus-host disease after allogeneic stem cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplantation, 29(1), 63-6.
Matsue K, et al. Eradication of Residual Bcr-abl-positive Clones By Inducing Graft-versus-host Disease After Allogeneic Stem Cell Transplantation in Patients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. Bone Marrow Transplant. 2002;29(1):63-6. PubMed PMID: 11840146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eradication of residual bcr-abl-positive clones by inducing graft-versus-host disease after allogeneic stem cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. AU - Matsue,K, AU - Tabayashi,T, AU - Yamada,K, AU - Takeuchi,M, PY - 2001/04/20/received PY - 2001/10/08/accepted PY - 2002/2/13/pubmed PY - 2003/4/18/medline PY - 2002/2/13/entrez SP - 63 EP - 6 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 29 IS - 1 N2 - Persistence of bcr-abl transcripts after marrow grafting is thought to convey a high risk for relapse in patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). Donor leukocyte infusion (DLI) is closely associated with development of graft-versus-host disease (GVHD) and has well-defined activity against relapsed chronic myelogenous leukemia (CML) but not ALL. We report two patients with Ph-positive ALL who remained bcr-abl positive by reverse transcriptase polymerase chain reaction (RT-PCR) after marrow grafting. Residual bcr-abl transcripts in both patients were eliminated following acute GVHD, which was induced by either DLI or rapid reduction of immunosuppression. Both patients have continued in complete molecular remission for 18 months and 8 months following transplantation, respectively. Our observation suggests that induction of GVHD may eliminate minimal residual disease, thereby preventing leukemia relapse in patients transplanted for Ph-positive ALL. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/11840146/Eradication_of_residual_bcr_abl_positive_clones_by_inducing_graft_versus_host_disease_after_allogeneic_stem_cell_transplantation_in_patients_with_Philadelphia_chromosome_positive_acute_lymphoblastic_leukemia_ L2 - https://doi.org/10.1038/sj.bmt.1703318 DB - PRIME DP - Unbound Medicine ER -