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Vegetarian diet ameliorates symptoms of atopic dermatitis through reduction of the number of peripheral eosinophils and of PGE2 synthesis by monocytes.

Abstract

Many patients with atopic dermatitis are dissatisfied with conventional treatments based on topical steroids and have experienced some traditional remedies and alternative therapies. However, most of such therapies have not been evaluated scientifically and clinically by specialists. This study was designed to assess whether a certain vegetarian diet might be effective for atopic dermatitis and if so, to identify the mechanisms of this remedy through analyses of immunological parameters. An open-trial study was carried out in twenty patients with atopic dermatitis. An improvement of dermatitis was evaluated by SCORAD index and serological and immunological parameters were monitored. After a two-month treatment, the severity of dermatitis was strikingly inhibited, as assessed by SCORAD index and serological parameters including LDH5 activity and a number of peripheral eosinophils. A sharp reduction in eosinophils and neutrophils was observed prior to improvement in the skin inflammation. In addition, PGE2 production by peripheral blood mononuclear cells was reduced by this treatment. In contrast, serum IgE levels did not change during the same period. Although this study is an open-trial one, it suggests that this treatment may be useful for the treatment of adult patients with severe atopic dermatitis.

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  • Authors+Show Affiliations

    ,

    Department III of Internal Medicine, Osaka University Medical School. ttanak@imed3.med.osaka-u.ac.jp

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    Source

    MeSH

    Adolescent
    Adult
    Dermatitis, Atopic
    Diet, Vegetarian
    Dinoprostone
    Eosinophils
    Female
    Humans
    Immunoglobulin E
    Inflammation
    Male
    Monocytes
    Severity of Illness Index
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    11840688

    Citation

    Tanaka, T, et al. "Vegetarian Diet Ameliorates Symptoms of Atopic Dermatitis Through Reduction of the Number of Peripheral Eosinophils and of PGE2 Synthesis By Monocytes." Journal of Physiological Anthropology and Applied Human Science, vol. 20, no. 6, 2001, pp. 353-61.
    Tanaka T, Kouda K, Kotani M, et al. Vegetarian diet ameliorates symptoms of atopic dermatitis through reduction of the number of peripheral eosinophils and of PGE2 synthesis by monocytes. J Physiol Anthropol Appl Human Sci. 2001;20(6):353-61.
    Tanaka, T., Kouda, K., Kotani, M., Takeuchi, A., Tabei, T., Masamoto, Y., ... Kouda, M. (2001). Vegetarian diet ameliorates symptoms of atopic dermatitis through reduction of the number of peripheral eosinophils and of PGE2 synthesis by monocytes. Journal of Physiological Anthropology and Applied Human Science, 20(6), pp. 353-61.
    Tanaka T, et al. Vegetarian Diet Ameliorates Symptoms of Atopic Dermatitis Through Reduction of the Number of Peripheral Eosinophils and of PGE2 Synthesis By Monocytes. J Physiol Anthropol Appl Human Sci. 2001;20(6):353-61. PubMed PMID: 11840688.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vegetarian diet ameliorates symptoms of atopic dermatitis through reduction of the number of peripheral eosinophils and of PGE2 synthesis by monocytes. AU - Tanaka,T, AU - Kouda,K, AU - Kotani,M, AU - Takeuchi,A, AU - Tabei,T, AU - Masamoto,Y, AU - Nakamura,H, AU - Takigawa,M, AU - Suemura,M, AU - Takeuchi,H, AU - Kouda,M, PY - 2002/2/14/pubmed PY - 2002/2/28/medline PY - 2002/2/14/entrez SP - 353 EP - 61 JF - Journal of physiological anthropology and applied human science JO - J Physiol Anthropol Appl Human Sci VL - 20 IS - 6 N2 - Many patients with atopic dermatitis are dissatisfied with conventional treatments based on topical steroids and have experienced some traditional remedies and alternative therapies. However, most of such therapies have not been evaluated scientifically and clinically by specialists. This study was designed to assess whether a certain vegetarian diet might be effective for atopic dermatitis and if so, to identify the mechanisms of this remedy through analyses of immunological parameters. An open-trial study was carried out in twenty patients with atopic dermatitis. An improvement of dermatitis was evaluated by SCORAD index and serological and immunological parameters were monitored. After a two-month treatment, the severity of dermatitis was strikingly inhibited, as assessed by SCORAD index and serological parameters including LDH5 activity and a number of peripheral eosinophils. A sharp reduction in eosinophils and neutrophils was observed prior to improvement in the skin inflammation. In addition, PGE2 production by peripheral blood mononuclear cells was reduced by this treatment. In contrast, serum IgE levels did not change during the same period. Although this study is an open-trial one, it suggests that this treatment may be useful for the treatment of adult patients with severe atopic dermatitis. SN - 1345-3475 UR - https://www.unboundmedicine.com/medline/citation/11840688/full_citation L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/jpa/20.353?from=PubMed DB - PRIME DP - Unbound Medicine ER -