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[Effects of polymorphism of apolipoprotein E gene on body mass index and plasma lipid levels in obese children].
Zhonghua Yu Fang Yi Xue Za Zhi. 2001 Nov; 35(6):412-4.ZY

Abstract

OBJECTIVE

To investigate the association between body mass index (BMI) and plasma lipid levels in obese children with different apolipoprotein E (ApoE) genotypes.

METHODS

BMI, ApoE genotype and plasma level of lipid were measured in 324 obese children. Genotype of ApoE was performed with polymerase chain reaction (PCR).

RESULTS

Distribution of genotypes was E3/3 in 198(61.1%), E3/4 in 36(11.1%), E2/3 in 54 (16.7%) and E4/4 in 36(11.1%). In the ApoE3 group, BMI correlated significantly with all indices of blood lipid (P < 0.05). However, with the exception of low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), apolipoprotein B (ApoB), correlation between other indices of blood lipid and BMI varied in the ApoE genotypes. In the ApoE2 group, BMI correlated significantly with TG (P < 0.05), but not with ApoA I or high-density lipoprotein-cholesterol (HDL-C). In the ApoE4 group, BMI correlated significant with HDL-C and ApoA I (P < 0.05), but not with TG.

CONCLUSION

Polymorphism of the ApoE gene could play a role in association of BMI with plasma level of lipid.

Authors+Show Affiliations

Department of Pediatrics Renmin Hospital of Wuhan University, Hubei 430060, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11840773

Citation

Zhang, X, et al. "[Effects of Polymorphism of Apolipoprotein E Gene On Body Mass Index and Plasma Lipid Levels in Obese Children]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 35, no. 6, 2001, pp. 412-4.
Zhang X, Xia G, Mai G. [Effects of polymorphism of apolipoprotein E gene on body mass index and plasma lipid levels in obese children]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001;35(6):412-4.
Zhang, X., Xia, G., & Mai, G. (2001). [Effects of polymorphism of apolipoprotein E gene on body mass index and plasma lipid levels in obese children]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 35(6), 412-4.
Zhang X, Xia G, Mai G. [Effects of Polymorphism of Apolipoprotein E Gene On Body Mass Index and Plasma Lipid Levels in Obese Children]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001;35(6):412-4. PubMed PMID: 11840773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of polymorphism of apolipoprotein E gene on body mass index and plasma lipid levels in obese children]. AU - Zhang,X, AU - Xia,G, AU - Mai,G, PY - 2002/2/14/pubmed PY - 2002/3/13/medline PY - 2002/2/14/entrez SP - 412 EP - 4 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 35 IS - 6 N2 - OBJECTIVE: To investigate the association between body mass index (BMI) and plasma lipid levels in obese children with different apolipoprotein E (ApoE) genotypes. METHODS: BMI, ApoE genotype and plasma level of lipid were measured in 324 obese children. Genotype of ApoE was performed with polymerase chain reaction (PCR). RESULTS: Distribution of genotypes was E3/3 in 198(61.1%), E3/4 in 36(11.1%), E2/3 in 54 (16.7%) and E4/4 in 36(11.1%). In the ApoE3 group, BMI correlated significantly with all indices of blood lipid (P < 0.05). However, with the exception of low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), apolipoprotein B (ApoB), correlation between other indices of blood lipid and BMI varied in the ApoE genotypes. In the ApoE2 group, BMI correlated significantly with TG (P < 0.05), but not with ApoA I or high-density lipoprotein-cholesterol (HDL-C). In the ApoE4 group, BMI correlated significant with HDL-C and ApoA I (P < 0.05), but not with TG. CONCLUSION: Polymorphism of the ApoE gene could play a role in association of BMI with plasma level of lipid. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/11840773/[Effects_of_polymorphism_of_apolipoprotein_E_gene_on_body_mass_index_and_plasma_lipid_levels_in_obese_children]_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -