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Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.
Planta Med. 2002 Jan; 68(1):49-54.PM

Abstract

Assay-guided fractionation of the ethanol extract of Tovomita krukovii resulted in the identification of four new xanthones (1 - 4) and ten known compounds (5 - 14). The structures of compounds 1 - 14 were determined by spectral data to be 3,5-dihydroxy-4-methoxyxanthone (1), 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (2), 1,3,5-trihydroxy-8-isoprenylxanthone (3), 1,5,7-trihydroxy-8-isoprenylxanthone (4), 1,3,7-trihydroxy-2-isoprenylxanthone (5), 1,5-dihydroxyxanthone (6), 1,6-dihydroxy-5-methoxyxanthone (7), 1,3,5-trihydroxyxanthone (8), 1,3,6-trihydroxy-5-methoxyxanthone (9), 1,6-dihydroxy-3,5-dimethoxyxanthone (10), 1,3,7-trihydroxyxanthone (11), 3-geranyl-2,4,6-trihydroxybenzophenone (12), betulinic acid (13), and 3,4-dihydroxybenzoic acid (14). Compounds 2, 3, 12 and 13 showed inhibitory effects against Candida albicans secreted aspartic proteases (SAP) with IC50 values of 15 microg/ml, 25 microg/ml, 40 microg/ml, and 6.5 microg/ml, respectively, while the other compounds were inactive. In addition, compound 12 showed activity against C. albicans, C. neoformans, S. aureus and methicillin resistant S. aureus (MRS).

Authors+Show Affiliations

National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Thad Cochran Research Center, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11842327

Citation

Zhang, Zhizhen, et al. "Natural Products Inhibiting Candida Albicans Secreted Aspartic Proteases From Tovomita Krukovii." Planta Medica, vol. 68, no. 1, 2002, pp. 49-54.
Zhang Z, ElSohly HN, Jacob MR, et al. Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. Planta Med. 2002;68(1):49-54.
Zhang, Z., ElSohly, H. N., Jacob, M. R., Pasco, D. S., Walker, L. A., & Clark, A. M. (2002). Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. Planta Medica, 68(1), 49-54.
Zhang Z, et al. Natural Products Inhibiting Candida Albicans Secreted Aspartic Proteases From Tovomita Krukovii. Planta Med. 2002;68(1):49-54. PubMed PMID: 11842327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. AU - Zhang,Zhizhen, AU - ElSohly,Hala N, AU - Jacob,Melissa R, AU - Pasco,David S, AU - Walker,Larry A, AU - Clark,Alice M, PY - 2002/2/14/pubmed PY - 2002/5/9/medline PY - 2002/2/14/entrez SP - 49 EP - 54 JF - Planta medica JO - Planta Med VL - 68 IS - 1 N2 - Assay-guided fractionation of the ethanol extract of Tovomita krukovii resulted in the identification of four new xanthones (1 - 4) and ten known compounds (5 - 14). The structures of compounds 1 - 14 were determined by spectral data to be 3,5-dihydroxy-4-methoxyxanthone (1), 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (2), 1,3,5-trihydroxy-8-isoprenylxanthone (3), 1,5,7-trihydroxy-8-isoprenylxanthone (4), 1,3,7-trihydroxy-2-isoprenylxanthone (5), 1,5-dihydroxyxanthone (6), 1,6-dihydroxy-5-methoxyxanthone (7), 1,3,5-trihydroxyxanthone (8), 1,3,6-trihydroxy-5-methoxyxanthone (9), 1,6-dihydroxy-3,5-dimethoxyxanthone (10), 1,3,7-trihydroxyxanthone (11), 3-geranyl-2,4,6-trihydroxybenzophenone (12), betulinic acid (13), and 3,4-dihydroxybenzoic acid (14). Compounds 2, 3, 12 and 13 showed inhibitory effects against Candida albicans secreted aspartic proteases (SAP) with IC50 values of 15 microg/ml, 25 microg/ml, 40 microg/ml, and 6.5 microg/ml, respectively, while the other compounds were inactive. In addition, compound 12 showed activity against C. albicans, C. neoformans, S. aureus and methicillin resistant S. aureus (MRS). SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/11842327/Natural_products_inhibiting_Candida_albicans_secreted_aspartic_proteases_from_Tovomita_krukovii_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-20049 DB - PRIME DP - Unbound Medicine ER -