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Autoimmune uveitis in children: clinical correlation between antinuclear antibody positivity and ocular recurrences.
Rheumatol Int. 2002 Jan; 21(4):127-32.RI

Abstract

OBJECTIVE

The aim of this study was to identify the correlation between antinuclear antibody (ANA) titre and the onset and clinical course of uveitis in children with juvenile idiopathic arthritis (JIA) or without any other systemic autoimmune disease, i.e., idiopathic uveitis (IU).

METHODS

Twenty-two patients affected by uveitis were examined. Ten had JIA-associated uveitis, 12 had IU. Follow-up ranged from 7 to 101 months. The ANA were titrated three times per year and additionally in case of ocular recurrences. All patients were treated with immunosuppressive drug combination therapy (IDCT).

RESULTS

JIA-associated uveitis: ocular recurrences were noted in three ANA-positive patients and in one ANA-negative patient. IU uveitis: ocular recurrences were noted in one ANA-positive and in one ANA-negative patient. No significant rise in ANA titre was noted in either group during uveitis recurrence.

CONCLUSIONS

(1) ANA had no value in predicting the recurrence of uveitis. (2) IDCT does not influence ANA production.

Authors+Show Affiliations

Manzotti F
Institute of Ophthalmology, University of Parma, Italy.
Orsoni JG
No affiliation info available
Zavota L
No affiliation info available
Cimino L
No affiliation info available
Zola E
No affiliation info available
Bonaguri C
No affiliation info available

MeSH

Age DistributionAge of OnsetAntibodies, AntinuclearArthritis, JuvenileAutoimmune DiseasesBiomarkersCase-Control StudiesChildChild, PreschoolFemaleFollow-Up StudiesHumansImmunosuppressive AgentsIncidenceMaleRecurrenceRisk FactorsSampling StudiesSeverity of Illness IndexSex DistributionUveitis

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11843166

Citation

Manzotti, Francesca, et al. "Autoimmune Uveitis in Children: Clinical Correlation Between Antinuclear Antibody Positivity and Ocular Recurrences." Rheumatology International, vol. 21, no. 4, 2002, pp. 127-32.
Manzotti F, Orsoni JG, Zavota L, et al. Autoimmune uveitis in children: clinical correlation between antinuclear antibody positivity and ocular recurrences. Rheumatol Int. 2002;21(4):127-32.
Manzotti, F., Orsoni, J. G., Zavota, L., Cimino, L., Zola, E., & Bonaguri, C. (2002). Autoimmune uveitis in children: clinical correlation between antinuclear antibody positivity and ocular recurrences. Rheumatology International, 21(4), 127-32.
Manzotti F, et al. Autoimmune Uveitis in Children: Clinical Correlation Between Antinuclear Antibody Positivity and Ocular Recurrences. Rheumatol Int. 2002;21(4):127-32. PubMed PMID: 11843166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoimmune uveitis in children: clinical correlation between antinuclear antibody positivity and ocular recurrences. AU - Manzotti,Francesca, AU - Orsoni,Jelka G, AU - Zavota,Laura, AU - Cimino,Luca, AU - Zola,Enrica, AU - Bonaguri,Chiara, PY - 2002/2/15/pubmed PY - 2002/8/16/medline PY - 2002/2/15/entrez SP - 127 EP - 32 JF - Rheumatology international JO - Rheumatol Int VL - 21 IS - 4 N2 - OBJECTIVE: The aim of this study was to identify the correlation between antinuclear antibody (ANA) titre and the onset and clinical course of uveitis in children with juvenile idiopathic arthritis (JIA) or without any other systemic autoimmune disease, i.e., idiopathic uveitis (IU). METHODS: Twenty-two patients affected by uveitis were examined. Ten had JIA-associated uveitis, 12 had IU. Follow-up ranged from 7 to 101 months. The ANA were titrated three times per year and additionally in case of ocular recurrences. All patients were treated with immunosuppressive drug combination therapy (IDCT). RESULTS: JIA-associated uveitis: ocular recurrences were noted in three ANA-positive patients and in one ANA-negative patient. IU uveitis: ocular recurrences were noted in one ANA-positive and in one ANA-negative patient. No significant rise in ANA titre was noted in either group during uveitis recurrence. CONCLUSIONS: (1) ANA had no value in predicting the recurrence of uveitis. (2) IDCT does not influence ANA production. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/11843166/Autoimmune_uveitis_in_children:_clinical_correlation_between_antinuclear_antibody_positivity_and_ocular_recurrences_ L2 - https://dx.doi.org/10.1007/s00296-001-0158-7 DB - PRIME DP - Unbound Medicine ER -