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Botulinum toxin A for palmar hyperhidrosis.
J Eur Acad Dermatol Venereol 2001; 15(6):555-8JE

Abstract

OBJECTIVE

We evaluated the efficacy and safety of intracutaneous injections of botulinum toxin A on severe palmar hyperhidrosis.

METHODS

Ten patients with recalcitrant palmar hyperhidrosis were treated with intercutaneous injections of botulinum toxin A (Botox; 200 U for each hand). Patients were followed up to 23 months (mean +/- SD: 12.1 +/- 6.2 months). RESULTS Botulinum toxin significantly reduced abnormal sweating within 1 week in 100% of the patients. In six patients with a follow-up of 12 months or more the antisudorific effect lasted 12.3 +/- 5.5 months. The longest response duration was 22 months. Repeated treatment was performed in five patients with unchanged clinical efficacy. The only side-effect was tolerable pain from the intracutaneous injections in patients where a nerve block was not performed.

CONCLUSIONS

Botulinum toxin A (200 U Botox per palm) was able to induce long-term remission in palmar hyperhidrosis without significant acute and long-term side-effects. Strictly intracutaneous injection of small volumes is recommended. So far, response to repeated treatments did not show evidence of neutralizing antibody induction.

Authors+Show Affiliations

Department of Dermatology and Allergology, the Friedrich-Schiller-University of Jena, Germany. Wollina-uw@khdf.deNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

11843216

Citation

Wollina, U, and T Karamfilov. "Botulinum Toxin a for Palmar Hyperhidrosis." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 15, no. 6, 2001, pp. 555-8.
Wollina U, Karamfilov T. Botulinum toxin A for palmar hyperhidrosis. J Eur Acad Dermatol Venereol. 2001;15(6):555-8.
Wollina, U., & Karamfilov, T. (2001). Botulinum toxin A for palmar hyperhidrosis. Journal of the European Academy of Dermatology and Venereology : JEADV, 15(6), pp. 555-8.
Wollina U, Karamfilov T. Botulinum Toxin a for Palmar Hyperhidrosis. J Eur Acad Dermatol Venereol. 2001;15(6):555-8. PubMed PMID: 11843216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Botulinum toxin A for palmar hyperhidrosis. AU - Wollina,U, AU - Karamfilov,T, PY - 2002/2/15/pubmed PY - 2002/8/1/medline PY - 2002/2/15/entrez SP - 555 EP - 8 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 15 IS - 6 N2 - OBJECTIVE: We evaluated the efficacy and safety of intracutaneous injections of botulinum toxin A on severe palmar hyperhidrosis. METHODS: Ten patients with recalcitrant palmar hyperhidrosis were treated with intercutaneous injections of botulinum toxin A (Botox; 200 U for each hand). Patients were followed up to 23 months (mean +/- SD: 12.1 +/- 6.2 months). RESULTS Botulinum toxin significantly reduced abnormal sweating within 1 week in 100% of the patients. In six patients with a follow-up of 12 months or more the antisudorific effect lasted 12.3 +/- 5.5 months. The longest response duration was 22 months. Repeated treatment was performed in five patients with unchanged clinical efficacy. The only side-effect was tolerable pain from the intracutaneous injections in patients where a nerve block was not performed. CONCLUSIONS: Botulinum toxin A (200 U Botox per palm) was able to induce long-term remission in palmar hyperhidrosis without significant acute and long-term side-effects. Strictly intracutaneous injection of small volumes is recommended. So far, response to repeated treatments did not show evidence of neutralizing antibody induction. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/11843216/Botulinum_toxin_A_for_palmar_hyperhidrosis L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0926-9959&date=2001&volume=15&issue=6&spage=555 DB - PRIME DP - Unbound Medicine ER -