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Selenium and glutathione levels, and glutathione peroxidase activities in blood components of uremic patients on hemodialysis supplemented with selenium and treated with erythropoietin.
J Trace Elem Med Biol. 2001; 15(4):201-8.JT

Abstract

Patients with chronic renal failure (CRF) often have reduced concentrations of selenium (Se) and lowered activities of glutathione peroxidase (GSH-Px) in blood components. The kidney is a major source of plasma GSH-Px. We measured Se and glutathione levels in blood components and red cell and plasma GSH-Px activities in 58 uremic patients on regular (3 times a week) hemodialysis (HD). The dialyzed patients were divided in 4 subgroups and were supplemented for 3 months with: 1) placebo (bakers yeast), 2) erythropoietin (EPO; 3 times a week with 2,000 U after each HD session), 3) Se-rich yeast (300 microg 3 times a week after each HD), and 4) Se-rich yeast plus EPO in doses as above. The results were compared with those for 25 healthy subjects. The Se concentrations and GSH-Px activities in the blood components of dialyzed uremic patients were significantly lower compared with the control group. Treatment of the HD patients with placebo and EPO only did not change the parameters studied. The treatment with Se as well as with Se and EPO caused an increase in Se levels and red cell GSH-Px activity. Plasma GSH-Px activity, however, increased only slowly or did not change after treatment with Se and with Se plus EPO. In the group treated with Se plus EPO the element concentration in blood components was higher compared with the group supplemented with Se alone. The weak or absence of response in plasma GSH-Px activity to Se supply indicates that the impaired kidney of uremic HD patients has reduced possibilities to synthesize this enzyme.

Authors+Show Affiliations

Department of Biochemistry, The Ludwik Rydygier Medical University, Bydgoszcz, Poland. bronzach@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11846008

Citation

Zachara, B A., et al. "Selenium and Glutathione Levels, and Glutathione Peroxidase Activities in Blood Components of Uremic Patients On Hemodialysis Supplemented With Selenium and Treated With Erythropoietin." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 15, no. 4, 2001, pp. 201-8.
Zachara BA, Adamowicz A, Trafikowska U, et al. Selenium and glutathione levels, and glutathione peroxidase activities in blood components of uremic patients on hemodialysis supplemented with selenium and treated with erythropoietin. J Trace Elem Med Biol. 2001;15(4):201-8.
Zachara, B. A., Adamowicz, A., Trafikowska, U., Trafikowska, A., Manitius, J., & Nartowicz, E. (2001). Selenium and glutathione levels, and glutathione peroxidase activities in blood components of uremic patients on hemodialysis supplemented with selenium and treated with erythropoietin. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 15(4), 201-8.
Zachara BA, et al. Selenium and Glutathione Levels, and Glutathione Peroxidase Activities in Blood Components of Uremic Patients On Hemodialysis Supplemented With Selenium and Treated With Erythropoietin. J Trace Elem Med Biol. 2001;15(4):201-8. PubMed PMID: 11846008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and glutathione levels, and glutathione peroxidase activities in blood components of uremic patients on hemodialysis supplemented with selenium and treated with erythropoietin. AU - Zachara,B A, AU - Adamowicz,A, AU - Trafikowska,U, AU - Trafikowska,A, AU - Manitius,J, AU - Nartowicz,E, PY - 2002/2/16/pubmed PY - 2002/8/20/medline PY - 2002/2/16/entrez SP - 201 EP - 8 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 15 IS - 4 N2 - Patients with chronic renal failure (CRF) often have reduced concentrations of selenium (Se) and lowered activities of glutathione peroxidase (GSH-Px) in blood components. The kidney is a major source of plasma GSH-Px. We measured Se and glutathione levels in blood components and red cell and plasma GSH-Px activities in 58 uremic patients on regular (3 times a week) hemodialysis (HD). The dialyzed patients were divided in 4 subgroups and were supplemented for 3 months with: 1) placebo (bakers yeast), 2) erythropoietin (EPO; 3 times a week with 2,000 U after each HD session), 3) Se-rich yeast (300 microg 3 times a week after each HD), and 4) Se-rich yeast plus EPO in doses as above. The results were compared with those for 25 healthy subjects. The Se concentrations and GSH-Px activities in the blood components of dialyzed uremic patients were significantly lower compared with the control group. Treatment of the HD patients with placebo and EPO only did not change the parameters studied. The treatment with Se as well as with Se and EPO caused an increase in Se levels and red cell GSH-Px activity. Plasma GSH-Px activity, however, increased only slowly or did not change after treatment with Se and with Se plus EPO. In the group treated with Se plus EPO the element concentration in blood components was higher compared with the group supplemented with Se alone. The weak or absence of response in plasma GSH-Px activity to Se supply indicates that the impaired kidney of uremic HD patients has reduced possibilities to synthesize this enzyme. SN - 0946-672X UR - https://www.unboundmedicine.com/medline/citation/11846008/Selenium_and_glutathione_levels_and_glutathione_peroxidase_activities_in_blood_components_of_uremic_patients_on_hemodialysis_supplemented_with_selenium_and_treated_with_erythropoietin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(01)80034-1 DB - PRIME DP - Unbound Medicine ER -