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The role of intravenous volume expansion in moderate pre-eclampsia.
Clin Hemorheol Microcirc. 2001; 25(3-4):83-9.CH

Abstract

We examined the hemodynamic and hemorheological effects of intravenous volume expansion in women with pre-eclampsia. 20 untreated women with moderate pre-eclampsia were randomized to receive a 500 ml infusion over 4 h of either hydroxyethylstarch (HAES steril 10%, HES) or NaCl 0.9% solution. After completion of the infusion trial all patients received oral antihypertensive drugs, bed rest and free sodium and water intake. The hemodynamic responses were measured by impedance cardiography. Hemorheological parameters and blood pressure were measured before and after (24 h later) infusion. The HES infusion but not NaCl leads to a significant reduction of hematocrit and erythrocyte aggregation. In addition to that there was a nonsignificant increase of the cardiac index in the HES-group but no changes in the heart rate. Intravenous volume expansion in women with pre-eclampsia with a long acting colloid like hydroxyethylstarch is associated with a significant influence on the flow properties (hematocrit and erythrocyte aggregation) of blood.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, City Hospital August, Bebel-Strasse 59, 65428 Ruesselsheim, Germany. lothalheilmann@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11847411

Citation

Heilmann, L, et al. "The Role of Intravenous Volume Expansion in Moderate Pre-eclampsia." Clinical Hemorheology and Microcirculation, vol. 25, no. 3-4, 2001, pp. 83-9.
Heilmann L, Gerhold S, von Tempelhoff GF, et al. The role of intravenous volume expansion in moderate pre-eclampsia. Clin Hemorheol Microcirc. 2001;25(3-4):83-9.
Heilmann, L., Gerhold, S., von Tempelhoff, G. F., & Pollow, K. (2001). The role of intravenous volume expansion in moderate pre-eclampsia. Clinical Hemorheology and Microcirculation, 25(3-4), 83-9.
Heilmann L, et al. The Role of Intravenous Volume Expansion in Moderate Pre-eclampsia. Clin Hemorheol Microcirc. 2001;25(3-4):83-9. PubMed PMID: 11847411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of intravenous volume expansion in moderate pre-eclampsia. AU - Heilmann,L, AU - Gerhold,S, AU - von Tempelhoff,G F, AU - Pollow,K, PY - 2002/2/16/pubmed PY - 2002/5/15/medline PY - 2002/2/16/entrez SP - 83 EP - 9 JF - Clinical hemorheology and microcirculation JO - Clin Hemorheol Microcirc VL - 25 IS - 3-4 N2 - We examined the hemodynamic and hemorheological effects of intravenous volume expansion in women with pre-eclampsia. 20 untreated women with moderate pre-eclampsia were randomized to receive a 500 ml infusion over 4 h of either hydroxyethylstarch (HAES steril 10%, HES) or NaCl 0.9% solution. After completion of the infusion trial all patients received oral antihypertensive drugs, bed rest and free sodium and water intake. The hemodynamic responses were measured by impedance cardiography. Hemorheological parameters and blood pressure were measured before and after (24 h later) infusion. The HES infusion but not NaCl leads to a significant reduction of hematocrit and erythrocyte aggregation. In addition to that there was a nonsignificant increase of the cardiac index in the HES-group but no changes in the heart rate. Intravenous volume expansion in women with pre-eclampsia with a long acting colloid like hydroxyethylstarch is associated with a significant influence on the flow properties (hematocrit and erythrocyte aggregation) of blood. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/11847411/The_role_of_intravenous_volume_expansion_in_moderate_pre_eclampsia_ L2 - http://www.diseaseinfosearch.org/result/2435 DB - PRIME DP - Unbound Medicine ER -