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Sucralfate in the treatment of chemotherapy-induced stomatitis: a double-blind, placebo-controlled pilot study.
Anticancer Res 2001 Sep-Oct; 21(5):3707-10AR

Abstract

BACKGROUND

The study was a double-blind, placebo-controlled, randomised pilot study to assess the efficacy of sucralfate gel in the treatment of chemotherapy-induced mucositis.

PATIENTS AND METHODS

At the onset of stomatitis, forty patients received sucralfate gel (1 gr.) or placebo and were instructed to apply the gel over oral mucosas, 3 times daily.

RESULTS

Objective response was observed in 14 patients (11 complete response+3 partial response) and in 15 patients (10 CR+5 PR), in the sucralfate and placebo arms, respectively; (p = NS). Analysis of VAS (visual analogue scale) scoring of pain did not detect any statistical difference between the two groups. No important side-effects were observed. Twelve out 21 patients who obtained a complete resolution of stomatitis (5 out of 11 and 7 out of 10 in the sucralfate and in placebo arms, respectively) received further treatment at the subsequent course of chemotherapy; prevention of mucositis was observed in 4 patients in the sucralfate arm and in 6 patients in the placebo arm, respectively.

CONCLUSION

In the present pilot study, sucralfate did not demonstrate a significant advantage in comparison to the placebo in the treatment of chemotherapy-induced stomatitis.

Authors+Show Affiliations

Department of Medical Oncology, National Institute for Cancer Research, Genova, Italy. schiara@hp380.ist.unige.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11848548

Citation

Chiara, S, et al. "Sucralfate in the Treatment of Chemotherapy-induced Stomatitis: a Double-blind, Placebo-controlled Pilot Study." Anticancer Research, vol. 21, no. 5, 2001, pp. 3707-10.
Chiara S, Nobile MT, Vincenti M, et al. Sucralfate in the treatment of chemotherapy-induced stomatitis: a double-blind, placebo-controlled pilot study. Anticancer Res. 2001;21(5):3707-10.
Chiara, S., Nobile, M. T., Vincenti, M., Gozza, A., Pastrone, I., Rosso, M., & Rosso, R. (2001). Sucralfate in the treatment of chemotherapy-induced stomatitis: a double-blind, placebo-controlled pilot study. Anticancer Research, 21(5), pp. 3707-10.
Chiara S, et al. Sucralfate in the Treatment of Chemotherapy-induced Stomatitis: a Double-blind, Placebo-controlled Pilot Study. Anticancer Res. 2001;21(5):3707-10. PubMed PMID: 11848548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sucralfate in the treatment of chemotherapy-induced stomatitis: a double-blind, placebo-controlled pilot study. AU - Chiara,S, AU - Nobile,M T, AU - Vincenti,M, AU - Gozza,A, AU - Pastrone,I, AU - Rosso,M, AU - Rosso,R, PY - 2002/2/19/pubmed PY - 2002/3/13/medline PY - 2002/2/19/entrez SP - 3707 EP - 10 JF - Anticancer research JO - Anticancer Res. VL - 21 IS - 5 N2 - BACKGROUND: The study was a double-blind, placebo-controlled, randomised pilot study to assess the efficacy of sucralfate gel in the treatment of chemotherapy-induced mucositis. PATIENTS AND METHODS: At the onset of stomatitis, forty patients received sucralfate gel (1 gr.) or placebo and were instructed to apply the gel over oral mucosas, 3 times daily. RESULTS: Objective response was observed in 14 patients (11 complete response+3 partial response) and in 15 patients (10 CR+5 PR), in the sucralfate and placebo arms, respectively; (p = NS). Analysis of VAS (visual analogue scale) scoring of pain did not detect any statistical difference between the two groups. No important side-effects were observed. Twelve out 21 patients who obtained a complete resolution of stomatitis (5 out of 11 and 7 out of 10 in the sucralfate and in placebo arms, respectively) received further treatment at the subsequent course of chemotherapy; prevention of mucositis was observed in 4 patients in the sucralfate arm and in 6 patients in the placebo arm, respectively. CONCLUSION: In the present pilot study, sucralfate did not demonstrate a significant advantage in comparison to the placebo in the treatment of chemotherapy-induced stomatitis. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/11848548/Sucralfate_in_the_treatment_of_chemotherapy_induced_stomatitis:_a_double_blind_placebo_controlled_pilot_study_ DB - PRIME DP - Unbound Medicine ER -