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Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains.
Neurosci Lett. 2002 Mar 01; 320(1-2):25-8.NL

Abstract

The association between the K-variant of the butyrylcholinesterase gene (BCHE-K) and Alzheimer disease (AD) or AD-related neuropathology has been reported to date with conflicting results. Here, we determined in a sample of 521 cases the severity of AD-related neuropathology and the polymorphisms of both BCHE-K and apolipoprotein E (ApoE). Histopathologically, all brains were classified according to procedures permitting differentiation of the evolutionary stages of neurofibrillary tangles (NFTs) and amyloid-beta-protein deposition (A beta-deposits). The results show that the association between BCHE-K and AD-related neuropathology only was limited to homozygotes for the K allele (P=0.036 for NFTs, and P=0.045 for A beta-deposits) at ages > or = 70 years but not 50-69 years. Furthermore, no interaction was apparent between BCHE-K and ApoE.

Authors+Show Affiliations

Department of Clinical Neuroanatomy, J.W. Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. ghebremedhin@em.uni-frankfurt.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11849755

Citation

Ghebremedhin, Estifanos, et al. "Age-dependent Association Between Butyrylcholinesterase K-variant and Alzheimer Disease-related Neuropathology in Human Brains." Neuroscience Letters, vol. 320, no. 1-2, 2002, pp. 25-8.
Ghebremedhin E, Thal DR, Schultz C, et al. Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains. Neurosci Lett. 2002;320(1-2):25-8.
Ghebremedhin, E., Thal, D. R., Schultz, C., & Braak, H. (2002). Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains. Neuroscience Letters, 320(1-2), 25-8.
Ghebremedhin E, et al. Age-dependent Association Between Butyrylcholinesterase K-variant and Alzheimer Disease-related Neuropathology in Human Brains. Neurosci Lett. 2002 Mar 1;320(1-2):25-8. PubMed PMID: 11849755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains. AU - Ghebremedhin,Estifanos, AU - Thal,Dietmar R, AU - Schultz,Christian, AU - Braak,Heiko, PY - 2002/2/19/pubmed PY - 2002/4/19/medline PY - 2002/2/19/entrez SP - 25 EP - 8 JF - Neuroscience letters JO - Neurosci. Lett. VL - 320 IS - 1-2 N2 - The association between the K-variant of the butyrylcholinesterase gene (BCHE-K) and Alzheimer disease (AD) or AD-related neuropathology has been reported to date with conflicting results. Here, we determined in a sample of 521 cases the severity of AD-related neuropathology and the polymorphisms of both BCHE-K and apolipoprotein E (ApoE). Histopathologically, all brains were classified according to procedures permitting differentiation of the evolutionary stages of neurofibrillary tangles (NFTs) and amyloid-beta-protein deposition (A beta-deposits). The results show that the association between BCHE-K and AD-related neuropathology only was limited to homozygotes for the K allele (P=0.036 for NFTs, and P=0.045 for A beta-deposits) at ages > or = 70 years but not 50-69 years. Furthermore, no interaction was apparent between BCHE-K and ApoE. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/11849755/Age_dependent_association_between_butyrylcholinesterase_K_variant_and_Alzheimer_disease_related_neuropathology_in_human_brains_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394002000149 DB - PRIME DP - Unbound Medicine ER -