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Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord.
J Neurosci 2002; 22(4):1228-37JN

Abstract

Using a spinal cord slice preparation and patch-clamp recordings from spinal cord dorsal horn neurons, we examined excitatory and inhibitory circuits connecting to lamina V neurons after the activation of afferent central terminal vanilloid receptor-1 (VR1) receptors and P2X receptors. We found that single neurons in lamina V often received excitatory inputs from two chemically defined afferent pathways. One of these pathways was polysynaptic from capsaicin-sensitive afferent terminals. In this pathway the capsaicin-sensitive afferent input first activated interneurons in superficial laminas, and then the excitatory activity was transmitted onto lamina V neurons. The second excitatory input was monosynaptic from alpha(beta)m-ATP-sensitive/capsaicin-insensitive afferent terminals. Both capsaicin-sensitive and alpha(beta)m-ATP-sensitive/capsaicin-insensitive pathways also recruited polysynaptic inhibitory inputs to lamina V neurons. Furthermore, we demonstrated that simultaneous activation of both capsaicin-sensitive afferent pathways and alpha(beta)m-ATP-sensitive/capsaicin-insensitive pathways could generate a temporal summation of excitatory inputs onto single lamina V neurons. These convergent pathways may provide a mechanism of sensory integration for two chemically defined sensory inputs and may have implications in different sensory states.

Authors+Show Affiliations

McKnight Brain Institute of the University of Florida and Division of Neuroscience, Department of Oral Surgery, College of Dentistry, University of Florida, Gainesville, Florida 32610, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11850450

Citation

Nakatsuka, Terumasa, et al. "Activation of Central Terminal Vanilloid Receptor-1 Receptors and Alpha beta-methylene-ATP-sensitive P2X Receptors Reveals a Converged Synaptic Activity Onto the Deep Dorsal Horn Neurons of the Spinal Cord." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 22, no. 4, 2002, pp. 1228-37.
Nakatsuka T, Furue H, Yoshimura M, et al. Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord. J Neurosci. 2002;22(4):1228-37.
Nakatsuka, T., Furue, H., Yoshimura, M., & Gu, J. G. (2002). Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 22(4), pp. 1228-37.
Nakatsuka T, et al. Activation of Central Terminal Vanilloid Receptor-1 Receptors and Alpha beta-methylene-ATP-sensitive P2X Receptors Reveals a Converged Synaptic Activity Onto the Deep Dorsal Horn Neurons of the Spinal Cord. J Neurosci. 2002 Feb 15;22(4):1228-37. PubMed PMID: 11850450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord. AU - Nakatsuka,Terumasa, AU - Furue,Hidemasa, AU - Yoshimura,Megumu, AU - Gu,Jianguo G, PY - 2002/2/19/pubmed PY - 2002/2/28/medline PY - 2002/2/19/entrez SP - 1228 EP - 37 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J. Neurosci. VL - 22 IS - 4 N2 - Using a spinal cord slice preparation and patch-clamp recordings from spinal cord dorsal horn neurons, we examined excitatory and inhibitory circuits connecting to lamina V neurons after the activation of afferent central terminal vanilloid receptor-1 (VR1) receptors and P2X receptors. We found that single neurons in lamina V often received excitatory inputs from two chemically defined afferent pathways. One of these pathways was polysynaptic from capsaicin-sensitive afferent terminals. In this pathway the capsaicin-sensitive afferent input first activated interneurons in superficial laminas, and then the excitatory activity was transmitted onto lamina V neurons. The second excitatory input was monosynaptic from alpha(beta)m-ATP-sensitive/capsaicin-insensitive afferent terminals. Both capsaicin-sensitive and alpha(beta)m-ATP-sensitive/capsaicin-insensitive pathways also recruited polysynaptic inhibitory inputs to lamina V neurons. Furthermore, we demonstrated that simultaneous activation of both capsaicin-sensitive afferent pathways and alpha(beta)m-ATP-sensitive/capsaicin-insensitive pathways could generate a temporal summation of excitatory inputs onto single lamina V neurons. These convergent pathways may provide a mechanism of sensory integration for two chemically defined sensory inputs and may have implications in different sensory states. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/11850450/Activation_of_central_terminal_vanilloid_receptor_1_receptors_and_alpha_beta_methylene_ATP_sensitive_P2X_receptors_reveals_a_converged_synaptic_activity_onto_the_deep_dorsal_horn_neurons_of_the_spinal_cord_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=11850450 DB - PRIME DP - Unbound Medicine ER -