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[Transmissible spongiform encephalopathies. History, epidemiology, etiological, hyphotheses].
Minerva Med. 2002 Feb; 93(1):59-73.MM

Abstract

The history of transmissible spongiform encephalopathies is shortly reviewed beginning with the Westminster parliament act in the year 1755 up to the description in 1996 of the variant of the Creutzfeldt-Jakob disease, transmitted from cattle to man by alimentary route. The epidemiological patterns of encephalopathies of the various animal species and of the four encephalopathies up to date reported in man are shortly described: Creutzfeldt-Jakob disease, Kuru, Gerstmann-Straussler-Scheinker disease, Fatal Familial Insomnia. Etiological hypotheses are discussed until the identification of Prions: PrPcell, on the surface of normal cells, PrPscr in the brain of humans and animals dead for these diseases. The strains of the PrPscr are described on the basis of some characters observed through the passages in rodents and of molecular pattern. The possible future epidemiological evolution of the vCJD is also discussed.

Authors+Show Affiliations

Direttore dellIstituto di Microbiologia dellUniversità di Firenze, Italy.

Pub Type(s)

English Abstract
Historical Article
Journal Article
Review

Language

ita

PubMed ID

11850614

Citation

Gargani, G. "[Transmissible Spongiform Encephalopathies. History, Epidemiology, Etiological, Hyphotheses]." Minerva Medica, vol. 93, no. 1, 2002, pp. 59-73.
Gargani G. [Transmissible spongiform encephalopathies. History, epidemiology, etiological, hyphotheses]. Minerva Med. 2002;93(1):59-73.
Gargani, G. (2002). [Transmissible spongiform encephalopathies. History, epidemiology, etiological, hyphotheses]. Minerva Medica, 93(1), 59-73.
Gargani G. [Transmissible Spongiform Encephalopathies. History, Epidemiology, Etiological, Hyphotheses]. Minerva Med. 2002;93(1):59-73. PubMed PMID: 11850614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Transmissible spongiform encephalopathies. History, epidemiology, etiological, hyphotheses]. A1 - Gargani,G, PY - 2002/2/19/pubmed PY - 2002/5/8/medline PY - 2002/2/19/entrez SP - 59 EP - 73 JF - Minerva medica JO - Minerva Med VL - 93 IS - 1 N2 - The history of transmissible spongiform encephalopathies is shortly reviewed beginning with the Westminster parliament act in the year 1755 up to the description in 1996 of the variant of the Creutzfeldt-Jakob disease, transmitted from cattle to man by alimentary route. The epidemiological patterns of encephalopathies of the various animal species and of the four encephalopathies up to date reported in man are shortly described: Creutzfeldt-Jakob disease, Kuru, Gerstmann-Straussler-Scheinker disease, Fatal Familial Insomnia. Etiological hypotheses are discussed until the identification of Prions: PrPcell, on the surface of normal cells, PrPscr in the brain of humans and animals dead for these diseases. The strains of the PrPscr are described on the basis of some characters observed through the passages in rodents and of molecular pattern. The possible future epidemiological evolution of the vCJD is also discussed. SN - 0026-4806 UR - https://www.unboundmedicine.com/medline/citation/11850614/[Transmissible_spongiform_encephalopathies__History_epidemiology_etiological_hyphotheses]_ DB - PRIME DP - Unbound Medicine ER -