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Leptin concentrations do not correlate with fat mass nor with metabolic risk factors in morbidly obese females.
Diabetes Nutr Metab. 2001 Dec; 14(6):329-36.DN

Abstract

AIMS

To investigate the determinants of leptinemia in a cohort of morbid obese females compared to those of normal weight and mild-to-moderate obesity, and the relationships between leptin and metabolic derangements associated with obesity.

METHODS

Recruited females were: moderately obese [n=44; body mass index (BMI) 25-40 kg/m2], morbidly obese (n=34; BMI > or = 40 kg/m2) and normal weight volunteers (n=12; BMI 19-25 kg/m2). Fat mass assessed by bioelectrical impedance and fat distribution by waist-to-hip ratio (WHR) were determined in all subjects. Biochemical determinations included plasma leptin, lipoprotein profile, fasting insulin and cortisol.

RESULTS

Plasma leptin values were significantly increased in morbid obese patients (54.95 +/- 1.8 ng/ml) compared to those moderately obese (30.2 +/- 1.7 ng/ml; p<0.001) and to controls (9.77 +/- 1.4 ng/ml; p<0.001). Fat and age-adjusted leptin values were not different between groups. When subjects with a BMI <40 kg/m2 were considered, plasma leptin was significantly and positively related to anthropometric variables (BMI, percentage body fat and WHR), total cholesterol, LDL-cholesterol, plasma triglycerides, AST, ALT and uric acid; and negatively with HDL-cholesterol. In contrast, when morbidly obese patients were analyzed separately, no relationships were observed between leptin concentrations and BMI, percentage of adiposity or biochemical variables. For obese patients no significant differences were observed in the adjusted leptin values with respect to the presence of diabetes, dyslipidemia or hypertension.

CONCLUSIONS

In morbidly obese women, the plasma leptin concentrations, although increased, do not reflect the amount of adipose stores, and as such, factors other than simply adiposity need to be invoked to explain the variation in leptin values.

Authors+Show Affiliations

Unitat de Nutrició Humana, Hospital Universitari Sant Joan de Reus, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11853365

Citation

García-Lorda, P, et al. "Leptin Concentrations Do Not Correlate With Fat Mass nor With Metabolic Risk Factors in Morbidly Obese Females." Diabetes, Nutrition & Metabolism, vol. 14, no. 6, 2001, pp. 329-36.
García-Lorda P, Bulló M, Vilà R, et al. Leptin concentrations do not correlate with fat mass nor with metabolic risk factors in morbidly obese females. Diabetes Nutr Metab. 2001;14(6):329-36.
García-Lorda, P., Bulló, M., Vilà, R., del Mar Grasa, M., Alemany, M., & Salas-Salvadó, J. (2001). Leptin concentrations do not correlate with fat mass nor with metabolic risk factors in morbidly obese females. Diabetes, Nutrition & Metabolism, 14(6), 329-36.
García-Lorda P, et al. Leptin Concentrations Do Not Correlate With Fat Mass nor With Metabolic Risk Factors in Morbidly Obese Females. Diabetes Nutr Metab. 2001;14(6):329-36. PubMed PMID: 11853365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin concentrations do not correlate with fat mass nor with metabolic risk factors in morbidly obese females. AU - García-Lorda,P, AU - Bulló,M, AU - Vilà,R, AU - del Mar Grasa,M, AU - Alemany,M, AU - Salas-Salvadó,J, PY - 2002/2/21/pubmed PY - 2002/7/20/medline PY - 2002/2/21/entrez SP - 329 EP - 36 JF - Diabetes, nutrition & metabolism JO - Diabetes Nutr Metab VL - 14 IS - 6 N2 - AIMS: To investigate the determinants of leptinemia in a cohort of morbid obese females compared to those of normal weight and mild-to-moderate obesity, and the relationships between leptin and metabolic derangements associated with obesity. METHODS: Recruited females were: moderately obese [n=44; body mass index (BMI) 25-40 kg/m2], morbidly obese (n=34; BMI > or = 40 kg/m2) and normal weight volunteers (n=12; BMI 19-25 kg/m2). Fat mass assessed by bioelectrical impedance and fat distribution by waist-to-hip ratio (WHR) were determined in all subjects. Biochemical determinations included plasma leptin, lipoprotein profile, fasting insulin and cortisol. RESULTS: Plasma leptin values were significantly increased in morbid obese patients (54.95 +/- 1.8 ng/ml) compared to those moderately obese (30.2 +/- 1.7 ng/ml; p<0.001) and to controls (9.77 +/- 1.4 ng/ml; p<0.001). Fat and age-adjusted leptin values were not different between groups. When subjects with a BMI <40 kg/m2 were considered, plasma leptin was significantly and positively related to anthropometric variables (BMI, percentage body fat and WHR), total cholesterol, LDL-cholesterol, plasma triglycerides, AST, ALT and uric acid; and negatively with HDL-cholesterol. In contrast, when morbidly obese patients were analyzed separately, no relationships were observed between leptin concentrations and BMI, percentage of adiposity or biochemical variables. For obese patients no significant differences were observed in the adjusted leptin values with respect to the presence of diabetes, dyslipidemia or hypertension. CONCLUSIONS: In morbidly obese women, the plasma leptin concentrations, although increased, do not reflect the amount of adipose stores, and as such, factors other than simply adiposity need to be invoked to explain the variation in leptin values. SN - 0394-3402 UR - https://www.unboundmedicine.com/medline/citation/11853365/Leptin_concentrations_do_not_correlate_with_fat_mass_nor_with_metabolic_risk_factors_in_morbidly_obese_females_ DB - PRIME DP - Unbound Medicine ER -