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Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States.
J Am Soc Nephrol. 2002 Mar; 13(3):745-753.JA

Abstract

Several epidemiologic studies reported that persons with renal insufficiency might have increased cardiovascular disease-related mortality rates in select populations. The association between renal insufficiency and increased cardiovascular disease-related and all-cause mortality rates during 16 yr of follow-up monitoring was examined among participants who were 30 to 74 yr of age at the baseline examinations in 1976 to 1980, with urinary protein dipstick measurements (n = 8786) or serum creatinine levels of <or=3.0 mg/dl (n = 6354), from the Second National Health and Nutrition Examination Survey Mortality Study. GFR were estimated by adjusting serum creatinine levels for age, race, and gender, using the Modification of Diet in Renal Disease formula. Cardiovascular disease-related mortality rates were 6.2, 17.9, and 37.2 deaths/1000 person-yr among subjects with urinary protein levels of <30, 30 to 299, and >or=300 mg/dl and were 4.1, 8.6, and 20.5 deaths/1000 person-yr among participants with estimated GFR of >or=90, 70 to 89, and <70 ml/min, respectively. After adjustment for potential confounders, the relative hazards (and 95% confidence intervals) for cardiovascular disease-related death were 1.57 (0.99 to 2.48) and 1.77 (0.97 to 3.21) among subjects with urinary protein levels of 30 to 299 and >or=300 mg/dl, respectively, compared with <30 mg/dl (P trend = 0.02). The corresponding relative hazards for all-cause-related death were 1.64 (1.23 to 2.18) and 2.00 (1.13 to 3.55; P trend < 0.001). Compared with subjects with estimated GFR of >or=90 ml/min, those with estimated GFR of <70 ml/min exhibited higher relative risks of death from cardiovascular disease and all causes [1.68 (1.33 to 2.13) and 1.51 (1.19 to 1.91), respectively]. This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates.

Authors+Show Affiliations

*Department of Epidemiology, School of Public Health and Tropical Medicine, and Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, and National Heart, Lung, and Blood Institute, Bethesda, Maryland.*Department of Epidemiology, School of Public Health and Tropical Medicine, and Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, and National Heart, Lung, and Blood Institute, Bethesda, Maryland.*Department of Epidemiology, School of Public Health and Tropical Medicine, and Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, and National Heart, Lung, and Blood Institute, Bethesda, Maryland.*Department of Epidemiology, School of Public Health and Tropical Medicine, and Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, and National Heart, Lung, and Blood Institute, Bethesda, Maryland.*Department of Epidemiology, School of Public Health and Tropical Medicine, and Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, and National Heart, Lung, and Blood Institute, Bethesda, Maryland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11856780

Citation

Muntner, Paul, et al. "Renal Insufficiency and Subsequent Death Resulting From Cardiovascular Disease in the United States." Journal of the American Society of Nephrology : JASN, vol. 13, no. 3, 2002, pp. 745-753.
Muntner P, He J, Hamm L, et al. Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. J Am Soc Nephrol. 2002;13(3):745-753.
Muntner, P., He, J., Hamm, L., Loria, C., & Whelton, P. K. (2002). Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. Journal of the American Society of Nephrology : JASN, 13(3), 745-753. https://doi.org/10.1681/ASN.V133745
Muntner P, et al. Renal Insufficiency and Subsequent Death Resulting From Cardiovascular Disease in the United States. J Am Soc Nephrol. 2002;13(3):745-753. PubMed PMID: 11856780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. AU - Muntner,Paul, AU - He,Jiang, AU - Hamm,Lee, AU - Loria,Catherine, AU - Whelton,Paul K, PY - 2002/2/22/pubmed PY - 2002/4/27/medline PY - 2002/2/22/entrez SP - 745 EP - 753 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 13 IS - 3 N2 - Several epidemiologic studies reported that persons with renal insufficiency might have increased cardiovascular disease-related mortality rates in select populations. The association between renal insufficiency and increased cardiovascular disease-related and all-cause mortality rates during 16 yr of follow-up monitoring was examined among participants who were 30 to 74 yr of age at the baseline examinations in 1976 to 1980, with urinary protein dipstick measurements (n = 8786) or serum creatinine levels of <or=3.0 mg/dl (n = 6354), from the Second National Health and Nutrition Examination Survey Mortality Study. GFR were estimated by adjusting serum creatinine levels for age, race, and gender, using the Modification of Diet in Renal Disease formula. Cardiovascular disease-related mortality rates were 6.2, 17.9, and 37.2 deaths/1000 person-yr among subjects with urinary protein levels of <30, 30 to 299, and >or=300 mg/dl and were 4.1, 8.6, and 20.5 deaths/1000 person-yr among participants with estimated GFR of >or=90, 70 to 89, and <70 ml/min, respectively. After adjustment for potential confounders, the relative hazards (and 95% confidence intervals) for cardiovascular disease-related death were 1.57 (0.99 to 2.48) and 1.77 (0.97 to 3.21) among subjects with urinary protein levels of 30 to 299 and >or=300 mg/dl, respectively, compared with <30 mg/dl (P trend = 0.02). The corresponding relative hazards for all-cause-related death were 1.64 (1.23 to 2.18) and 2.00 (1.13 to 3.55; P trend < 0.001). Compared with subjects with estimated GFR of >or=90 ml/min, those with estimated GFR of <70 ml/min exhibited higher relative risks of death from cardiovascular disease and all causes [1.68 (1.33 to 2.13) and 1.51 (1.19 to 1.91), respectively]. This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/11856780/Renal_insufficiency_and_subsequent_death_resulting_from_cardiovascular_disease_in_the_United_States_ L2 - https://jasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=11856780 DB - PRIME DP - Unbound Medicine ER -