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Characteristics of Puumala and Dobrava infections in Croatia.
J Med Virol. 2002 Apr; 66(4):542-51.JM

Abstract

In this study, two different hantaviruses, Puumala virus (PUUV) and Dobrava virus (DOBV), were demonstrated for the first time to coexist and cause hemorrhagic fever with renal syndrome (HFRS) in Croatia. Phylogenetic analysis showed some differences among the nucleotide sequences of PUUV originating from Dinara mountain, which was more closely related to Austrian PUUV than other Croatian PUUV from Mala Kapela mountain. More consistency was found among the Croatian DOBV. HFRS was verified in 85 of 201 suspected cases recorded in 1995 during the largest HFRS outbreak in Croatia. Most of these cases were soldiers. With the exception of the coastal region and islands, all of Croatia was found to be an area endemic for HFRS. A statistically significantly higher proportion of DOBV-infected patients had acute renal failure, visual disturbance, severe thrombocytopenia, and elevated levels of nonsegmented leukocytes, creatine, and total bilirubin. The prevalence of gastrointestinal and electrocardiography disorders also was greater in DOBV-infected patients. Interestingly, significantly more PUUV-infected patients had elevated systolic blood pressure on admission to the hospital. Further prospective studies are necessary to shed more light on differences in HFRS severity associated with PUU and DOB viruses.

Authors+Show Affiliations

Institute of Immunology, Zagreb, Croatia. alemka.markotic@imz.tel.hrNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11857535

Citation

Markotić, A, et al. "Characteristics of Puumala and Dobrava Infections in Croatia." Journal of Medical Virology, vol. 66, no. 4, 2002, pp. 542-51.
Markotić A, Nichol ST, Kuzman I, et al. Characteristics of Puumala and Dobrava infections in Croatia. J Med Virol. 2002;66(4):542-51.
Markotić, A., Nichol, S. T., Kuzman, I., Sanchez, A. J., Ksiazek, T. G., Gagro, A., Rabatić, S., Zgorelec, R., Avsic-Zupanc, T., Beus, I., & Dekaris, D. (2002). Characteristics of Puumala and Dobrava infections in Croatia. Journal of Medical Virology, 66(4), 542-51.
Markotić A, et al. Characteristics of Puumala and Dobrava Infections in Croatia. J Med Virol. 2002;66(4):542-51. PubMed PMID: 11857535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of Puumala and Dobrava infections in Croatia. AU - Markotić,A, AU - Nichol,S T, AU - Kuzman,I, AU - Sanchez,A J, AU - Ksiazek,T G, AU - Gagro,A, AU - Rabatić,S, AU - Zgorelec,R, AU - Avsic-Zupanc,T, AU - Beus,I, AU - Dekaris,D, PY - 2002/2/22/pubmed PY - 2002/5/16/medline PY - 2002/2/22/entrez SP - 542 EP - 51 JF - Journal of medical virology JO - J. Med. Virol. VL - 66 IS - 4 N2 - In this study, two different hantaviruses, Puumala virus (PUUV) and Dobrava virus (DOBV), were demonstrated for the first time to coexist and cause hemorrhagic fever with renal syndrome (HFRS) in Croatia. Phylogenetic analysis showed some differences among the nucleotide sequences of PUUV originating from Dinara mountain, which was more closely related to Austrian PUUV than other Croatian PUUV from Mala Kapela mountain. More consistency was found among the Croatian DOBV. HFRS was verified in 85 of 201 suspected cases recorded in 1995 during the largest HFRS outbreak in Croatia. Most of these cases were soldiers. With the exception of the coastal region and islands, all of Croatia was found to be an area endemic for HFRS. A statistically significantly higher proportion of DOBV-infected patients had acute renal failure, visual disturbance, severe thrombocytopenia, and elevated levels of nonsegmented leukocytes, creatine, and total bilirubin. The prevalence of gastrointestinal and electrocardiography disorders also was greater in DOBV-infected patients. Interestingly, significantly more PUUV-infected patients had elevated systolic blood pressure on admission to the hospital. Further prospective studies are necessary to shed more light on differences in HFRS severity associated with PUU and DOB viruses. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/11857535/Characteristics_of_Puumala_and_Dobrava_infections_in_Croatia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=2002&volume=66&issue=4&spage=542 DB - PRIME DP - Unbound Medicine ER -