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Serum insulin/like growth factor I, bone mineral density and biochemical markers of bone metabolism in children with idiopathic osteoporosis.
Endocr Regul. 2001 Dec; 35(4):201-8.ER

Abstract

OBJECTIVE

To determine whether the serum concentration of insulin-like growth factor I (IGF-I) correlates with the occurrence of idiopathic osteoporosis in children, and whether serum levels of IGF-I correlate with selected bone metabolism markers in patients with osteoporosis.

METHODS

The study comprised 24 patients aged 7-18 years, including 12 with idiopathic osteoporosis and 12 control children. Bone mineralisation disorders were diagnosed on the basis of complex clinical, densitometric and biochemical evaluation. In all children serum concentration of IGF-I was estimated by radioimmunoassay and the third fraction of IGF binding proteins (IGFBP3) by immunoradiometry. In children with osteoporosis the indices of bone metabolism were also assessed, e.g. serum levels of osteocalcin and activity of bone isoenzyme of alkaline phosphatase (bone formation markers) and urine concentration of pyridinoline and deoxypyridinoline and collagen type I crosslinked C-telopeptyde (resorption markers).

RESULTS

It was found that in children with osteoporosis IGF-I concentration was significantly lower than in the control group (mean values were 583 and 850 ng/ml, respectively; P<0.05). These differences were independent on biological age of the studied children and were present in all adolescence stages. Concentrations of IGFBP3 did not differ significantly between groups (3593 vs. 3955 ng/ml), while that of IFG-I correlated positively with total and spinal bone mineral density (R=0.85 and R=0.80, respectively; P<0.00001). In children with osteoporosis there was also a significant relationship between IGF-I concentration and elimination of pyridinoline and deoxypyridinoline with urine (R=0.64 and R=0.65, respectively; P<0.05). There was no significant correlation between the concentration of IGF-I and IGFBP3 and other studied bone metabolism markers.

CONCLUSIONS

The conducted study revealed that lower IFG-I concentrations correlate with higher bone resorption markers values and decreased mineralisation. These results suggest the importance of insulin-like growth factor in the ethiopathogenesis of idiopathic osteoporosis, which needs to be confirmed in further studies.

Authors+Show Affiliations

Department of Paediatric Propedeutics, Institute of Paediatry, Medical University of Lodz, 91-738, Lodz, Poland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11858767

Citation

Chlebna-Sokol, D, and A Rusinska. "Serum Insulin/like Growth Factor I, Bone Mineral Density and Biochemical Markers of Bone Metabolism in Children With Idiopathic Osteoporosis." Endocrine Regulations, vol. 35, no. 4, 2001, pp. 201-8.
Chlebna-Sokol D, Rusinska A. Serum insulin/like growth factor I, bone mineral density and biochemical markers of bone metabolism in children with idiopathic osteoporosis. Endocr Regul. 2001;35(4):201-8.
Chlebna-Sokol, D., & Rusinska, A. (2001). Serum insulin/like growth factor I, bone mineral density and biochemical markers of bone metabolism in children with idiopathic osteoporosis. Endocrine Regulations, 35(4), 201-8.
Chlebna-Sokol D, Rusinska A. Serum Insulin/like Growth Factor I, Bone Mineral Density and Biochemical Markers of Bone Metabolism in Children With Idiopathic Osteoporosis. Endocr Regul. 2001;35(4):201-8. PubMed PMID: 11858767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum insulin/like growth factor I, bone mineral density and biochemical markers of bone metabolism in children with idiopathic osteoporosis. AU - Chlebna-Sokol,D, AU - Rusinska,A, PY - 2002/2/23/pubmed PY - 2002/6/5/medline PY - 2002/2/23/entrez SP - 201 EP - 8 JF - Endocrine regulations JO - Endocr Regul VL - 35 IS - 4 N2 - OBJECTIVE: To determine whether the serum concentration of insulin-like growth factor I (IGF-I) correlates with the occurrence of idiopathic osteoporosis in children, and whether serum levels of IGF-I correlate with selected bone metabolism markers in patients with osteoporosis. METHODS: The study comprised 24 patients aged 7-18 years, including 12 with idiopathic osteoporosis and 12 control children. Bone mineralisation disorders were diagnosed on the basis of complex clinical, densitometric and biochemical evaluation. In all children serum concentration of IGF-I was estimated by radioimmunoassay and the third fraction of IGF binding proteins (IGFBP3) by immunoradiometry. In children with osteoporosis the indices of bone metabolism were also assessed, e.g. serum levels of osteocalcin and activity of bone isoenzyme of alkaline phosphatase (bone formation markers) and urine concentration of pyridinoline and deoxypyridinoline and collagen type I crosslinked C-telopeptyde (resorption markers). RESULTS: It was found that in children with osteoporosis IGF-I concentration was significantly lower than in the control group (mean values were 583 and 850 ng/ml, respectively; P<0.05). These differences were independent on biological age of the studied children and were present in all adolescence stages. Concentrations of IGFBP3 did not differ significantly between groups (3593 vs. 3955 ng/ml), while that of IFG-I correlated positively with total and spinal bone mineral density (R=0.85 and R=0.80, respectively; P<0.00001). In children with osteoporosis there was also a significant relationship between IGF-I concentration and elimination of pyridinoline and deoxypyridinoline with urine (R=0.64 and R=0.65, respectively; P<0.05). There was no significant correlation between the concentration of IGF-I and IGFBP3 and other studied bone metabolism markers. CONCLUSIONS: The conducted study revealed that lower IFG-I concentrations correlate with higher bone resorption markers values and decreased mineralisation. These results suggest the importance of insulin-like growth factor in the ethiopathogenesis of idiopathic osteoporosis, which needs to be confirmed in further studies. SN - 1210-0668 UR - https://www.unboundmedicine.com/medline/citation/11858767/Serum_insulin/like_growth_factor_I_bone_mineral_density_and_biochemical_markers_of_bone_metabolism_in_children_with_idiopathic_osteoporosis_ L2 - https://biocyc.org/gene?orgid=HUMAN&amp;id=HS00381 DB - PRIME DP - Unbound Medicine ER -