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Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity.
Planta Med. 2002 Feb; 68(2):175-8.PM

Abstract

The natural product aesculin was demonstrated to possess potent hypouricemic effects in in vivo models of hyperuricemia in both mice and rats pretreated with oxonate. Aesculin, when administered intraperitoneally to the oxonate-induced hyperuricemic rodents, was able to elicit dose-dependent hypouricemic effects. At doses of 150 mg/kg of aesculin or above, the serum urate levels of the oxonate-pretreated mice were not different from normal mice. Such an effect in mice was observed as quick as 1.5 h after aesculin administration and was persistent for at least 5 h after aesculin administration. In rats, similar hypouricemic effects of intraperitoneally administered aesculin could also be demonstrated at doses of 100 mg/kg of aesculin or above, the serum urate levels of the oxonate-pretreated rats were not different from normal rats. Again, the effect persisted for at least 5 h after aesculin administration. In both rodents, however, oral administration at the same doses did not produce any observable hypouricemic effects. In addition, aesculin, when tested in vitro on rat and mouse liver homogenates, did not elicit any measurable inhibitory actions on the xanthine oxidase/xanthine dehydrogenase activities.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11859475

Citation

Kong, Lingdong, et al. "Aesculin Possesses Potent Hypouricemic Action in Rodents but Is Devoid of Xanthine Oxidase/dehydrogenase Inhibitory Activity." Planta Medica, vol. 68, no. 2, 2002, pp. 175-8.
Kong L, Zhou J, Wen Y, et al. Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity. Planta Med. 2002;68(2):175-8.
Kong, L., Zhou, J., Wen, Y., Li, J., & Cheng, C. H. (2002). Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity. Planta Medica, 68(2), 175-8.
Kong L, et al. Aesculin Possesses Potent Hypouricemic Action in Rodents but Is Devoid of Xanthine Oxidase/dehydrogenase Inhibitory Activity. Planta Med. 2002;68(2):175-8. PubMed PMID: 11859475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity. AU - Kong,Lingdong, AU - Zhou,Jin, AU - Wen,Yaolin, AU - Li,Jianmei, AU - Cheng,Christopher H K, PY - 2002/2/23/pubmed PY - 2002/5/29/medline PY - 2002/2/23/entrez SP - 175 EP - 8 JF - Planta medica JO - Planta Med. VL - 68 IS - 2 N2 - The natural product aesculin was demonstrated to possess potent hypouricemic effects in in vivo models of hyperuricemia in both mice and rats pretreated with oxonate. Aesculin, when administered intraperitoneally to the oxonate-induced hyperuricemic rodents, was able to elicit dose-dependent hypouricemic effects. At doses of 150 mg/kg of aesculin or above, the serum urate levels of the oxonate-pretreated mice were not different from normal mice. Such an effect in mice was observed as quick as 1.5 h after aesculin administration and was persistent for at least 5 h after aesculin administration. In rats, similar hypouricemic effects of intraperitoneally administered aesculin could also be demonstrated at doses of 100 mg/kg of aesculin or above, the serum urate levels of the oxonate-pretreated rats were not different from normal rats. Again, the effect persisted for at least 5 h after aesculin administration. In both rodents, however, oral administration at the same doses did not produce any observable hypouricemic effects. In addition, aesculin, when tested in vitro on rat and mouse liver homogenates, did not elicit any measurable inhibitory actions on the xanthine oxidase/xanthine dehydrogenase activities. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/11859475/Aesculin_possesses_potent_hypouricemic_action_in_rodents_but_is_devoid_of_xanthine_oxidase/dehydrogenase_inhibitory_activity_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-20262 DB - PRIME DP - Unbound Medicine ER -