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Effects of ropivacaine on sodium, calcium, and potassium currents in guinea pig ventricular myocytes.
Acta Pharmacol Sin. 2002 Jan; 23(1):50-4.AP

Abstract

AIM

To study the effects of ropivacaine (Rop) on sodium current (INa), L-type calcium current (ICa-L), inward rectifier potassium current (IK1), and delayed rectifier potassium current (IK) in isolated guinea pig ventricular myocytes.

METHODS

Whole cell patch-clamp techniques were used in our experiment.

RESULTS

At potential of -40 mV, Rop 10, 50, and 100 micromol/L decreased sodium current by 8.3 %, 33.3 %, and 62.5 %, respectively and prolonged the time constant of INa inactivation by 8.2 %, 24.7 %, and 64.4 %, respectively (n = 5 cells from 3 animals, P < 0.05). At potential of +10 mV, Rop 50 and 100 micromol/L decreased L-type calcium current by 7.6 % and 22.5 %, and prolonged the slow time constant of ICa-L inactivation by 15.5 % and 33.0 %, respectively (n = 5 cells from 4 animals, P < 0.05). Rop 50 and 100 micromol/L did not markedly change the peak current of delayed rectifier potassium current and inward rectifier potassium current (n = 5 cells from 3 animals, P > 0.05), respectively.

CONCLUSION

Rop depressed INa and ICa-L, which may be related to its cardiotoxic effect

Authors+Show Affiliations

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China. hailei0314@263.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11860737

Citation

Ding, Hai-Lei, et al. "Effects of Ropivacaine On Sodium, Calcium, and Potassium Currents in Guinea Pig Ventricular Myocytes." Acta Pharmacologica Sinica, vol. 23, no. 1, 2002, pp. 50-4.
Ding HL, Zeng YM, Li XD, et al. Effects of ropivacaine on sodium, calcium, and potassium currents in guinea pig ventricular myocytes. Acta Pharmacol Sin. 2002;23(1):50-4.
Ding, H. L., Zeng, Y. M., Li, X. D., Jiang, W. P., & Duan, S. M. (2002). Effects of ropivacaine on sodium, calcium, and potassium currents in guinea pig ventricular myocytes. Acta Pharmacologica Sinica, 23(1), 50-4.
Ding HL, et al. Effects of Ropivacaine On Sodium, Calcium, and Potassium Currents in Guinea Pig Ventricular Myocytes. Acta Pharmacol Sin. 2002;23(1):50-4. PubMed PMID: 11860737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ropivacaine on sodium, calcium, and potassium currents in guinea pig ventricular myocytes. AU - Ding,Hai-Lei, AU - Zeng,Yin-Ming, AU - Li,Xiao-Dong, AU - Jiang,Wen-Ping, AU - Duan,Shi-Ming, PY - 2002/2/28/pubmed PY - 2003/9/17/medline PY - 2002/2/28/entrez SP - 50 EP - 4 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 23 IS - 1 N2 - AIM: To study the effects of ropivacaine (Rop) on sodium current (INa), L-type calcium current (ICa-L), inward rectifier potassium current (IK1), and delayed rectifier potassium current (IK) in isolated guinea pig ventricular myocytes. METHODS: Whole cell patch-clamp techniques were used in our experiment. RESULTS: At potential of -40 mV, Rop 10, 50, and 100 micromol/L decreased sodium current by 8.3 %, 33.3 %, and 62.5 %, respectively and prolonged the time constant of INa inactivation by 8.2 %, 24.7 %, and 64.4 %, respectively (n = 5 cells from 3 animals, P < 0.05). At potential of +10 mV, Rop 50 and 100 micromol/L decreased L-type calcium current by 7.6 % and 22.5 %, and prolonged the slow time constant of ICa-L inactivation by 15.5 % and 33.0 %, respectively (n = 5 cells from 4 animals, P < 0.05). Rop 50 and 100 micromol/L did not markedly change the peak current of delayed rectifier potassium current and inward rectifier potassium current (n = 5 cells from 3 animals, P > 0.05), respectively. CONCLUSION: Rop depressed INa and ICa-L, which may be related to its cardiotoxic effect SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/11860737/Effects_of_ropivacaine_on_sodium_calcium_and_potassium_currents_in_guinea_pig_ventricular_myocytes_ L2 - http://www.chinaphar.com/1671-4083/23/50.pdf DB - PRIME DP - Unbound Medicine ER -