[Association between apolipoprotein E polymorphism and Alzheimer's disease: A population-based study in Guangzhou, China].
Zhonghua Liu Xing Bing Xue Za Zhi. 2001 Jun; 22(3):202-4.ZL

Abstract

OBJECTIVE

To investigate the distribution of apolipoprotein E (apoE) genotype of patients with Alzheimer's disease (AD) in the population aged 75 and older in Guangzhou and to determine whether there was an association between AD and apoE epsilon4 allele.

METHODS

A systematic cluster sampling design, two-stage screening and field evaluations were used in a cross-sectional population-based study. Three thousand eight handred and twenty-five subjects aged 75 and above in Liwan district of Guangzhou were interviewed. Blood samples were collected from 110 cases and 518 normal controls. The criteria of DSM-III-R and NINCDS-ADRDA were used for clinical diagnosis of probable AD. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to determine apoE genotypes.

RESULTS

There were 190 cases diagnosed as sporadic AD from this sample. The frequencies of the three apoE alleles were detected as follows: epsilon2 = 0.100, epsilon3 = 0.832, epsilon4 = 0.068 in AD patients; epsilon2 = 0.092, epsilon3 = 0.843, epsilon4 = 0.065 in normal controls. The frequencies of apoE genotype and allele in the AD patients were not significantly different from that in normal subjects (P > 0.05).

CONCLUSION

No association between sporadic AD and apoE epsilon4 allele was found among the population aged 75 and above in Liwan district of Guangzhou.

Authors+Show Affiliations

Lai S

Guangzhou University of Tradition Chinese Medicine, Guangzhou 510405, China.

Chen Y

No affiliation info available

Wen Z

No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseApolipoproteins EFemaleHumansMalePolymorphism, Genetic

Pub Type(s)

English Abstract

Journal Article

Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11860878

Citation

Lai, S, et al. "[Association Between Apolipoprotein E Polymorphism and Alzheimer's Disease: a Population-based Study in Guangzhou, China]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 22, no. 3, 2001, pp. 202-4.

Lai S, Chen Y, Wen Z. [Association between apolipoprotein E polymorphism and Alzheimer's disease: A population-based study in Guangzhou, China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2001;22(3):202-4.

Lai, S., Chen, Y., & Wen, Z. (2001). [Association between apolipoprotein E polymorphism and Alzheimer's disease: A population-based study in Guangzhou, China]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 22(3), 202-4.

Lai S, Chen Y, Wen Z. [Association Between Apolipoprotein E Polymorphism and Alzheimer's Disease: a Population-based Study in Guangzhou, China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2001;22(3):202-4. PubMed PMID: 11860878.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Association between apolipoprotein E polymorphism and Alzheimer's disease: A population-based study in Guangzhou, China]. AU - Lai,S, AU - Chen,Y, AU - Wen,Z, PY - 2002/2/28/pubmed PY - 2003/10/3/medline PY - 2002/2/28/entrez SP - 202 EP - 4 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 22 IS - 3 N2 - OBJECTIVE: To investigate the distribution of apolipoprotein E (apoE) genotype of patients with Alzheimer's disease (AD) in the population aged 75 and older in Guangzhou and to determine whether there was an association between AD and apoE epsilon4 allele. METHODS: A systematic cluster sampling design, two-stage screening and field evaluations were used in a cross-sectional population-based study. Three thousand eight handred and twenty-five subjects aged 75 and above in Liwan district of Guangzhou were interviewed. Blood samples were collected from 110 cases and 518 normal controls. The criteria of DSM-III-R and NINCDS-ADRDA were used for clinical diagnosis of probable AD. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to determine apoE genotypes. RESULTS: There were 190 cases diagnosed as sporadic AD from this sample. The frequencies of the three apoE alleles were detected as follows: epsilon2 = 0.100, epsilon3 = 0.832, epsilon4 = 0.068 in AD patients; epsilon2 = 0.092, epsilon3 = 0.843, epsilon4 = 0.065 in normal controls. The frequencies of apoE genotype and allele in the AD patients were not significantly different from that in normal subjects (P > 0.05). CONCLUSION: No association between sporadic AD and apoE epsilon4 allele was found among the population aged 75 and above in Liwan district of Guangzhou. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/11860878/[Association_between_apolipoprotein_E_polymorphism_and_Alzheimer's_disease:_A_population_based_study_in_Guangzhou_China]_ L2 - https://www.diseaseinfosearch.org/result/349 DB - PRIME DP - Unbound Medicine ER -

Tags

[Association between apolipoprotein E polymorphism and Alzheimer's disease: A population-based study in Guangzhou, China].Zhonghua Liu Xing Bing Xue Za Zhi. 2001 Jun; 22(3):202-4.ZL