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[Relationship between folate, vitamin B12, total plasma homocysteine and mutation of reductase].
Zhonghua Yu Fang Yi Xue Za Zhi. 2000 Jan; 34(1):22-4.ZY

Abstract

OBJECTIVE

To study relationship between serum and red blood cell (RBC) folate, serum vitamin B(12) (VB(12)), total plasma homocysteine (tHcy), thermolabile genotypes, and activity of methylene-tetrahydrofolate reductase (MTHFR).

METHODS

Thirty-four non-pregnant and healthy mothers who gave birth to babies with neural tube defects (NTDs) and 42 mothers to normal babies previously were chosen. Plasma tHcy, RBC and serum folate, serum VB(12), activity of MTHFR and thermolabile genotypes were determined for all of them.

RESULTS

There was no significant difference in plasma tHcy, RBC and serun folate between case and control groups. Serum VB(12) was significantly lower in mothers of babies with NTDs than in those with normal ones. Plasma tHcy correlated with RBC folate inversely (P < 0.05). Mean plasma tHcy for thermolabile homozygous mutation of MTHFR was significantly higher than that for either heterozygous mutation or wild homozygous mutation (P < 0.001). There was no significant difference in serum folate between groups with varied MTHFR genotypes. Plasma tHcy was slightly greater in those with lower serum folate than in those with higher one, and correlated inversely with activity of MTHFR.

CONCLUSIONS

Increase in plasma tHcy correlates with homozygous mutation of thermolabile MTHFR and decrease in activity of MTHFR. Higher level of folate in the body can interfere the relationship between plasma tHcy and activity of MTHFR.

Authors+Show Affiliations

National Reference Laboratory for Reproductive Health Research, Beijing Medical University, Beijing, 100083, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11860891

Citation

Hao, L, et al. "[Relationship Between Folate, Vitamin B12, Total Plasma Homocysteine and Mutation of Reductase]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 34, no. 1, 2000, pp. 22-4.
Hao L, Liu M, Liu X, et al. [Relationship between folate, vitamin B12, total plasma homocysteine and mutation of reductase]. Zhonghua Yu Fang Yi Xue Za Zhi. 2000;34(1):22-4.
Hao, L., Liu, M., Liu, X., Chen, X., Tang, Y., & Li, Z. (2000). [Relationship between folate, vitamin B12, total plasma homocysteine and mutation of reductase]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 34(1), 22-4.
Hao L, et al. [Relationship Between Folate, Vitamin B12, Total Plasma Homocysteine and Mutation of Reductase]. Zhonghua Yu Fang Yi Xue Za Zhi. 2000;34(1):22-4. PubMed PMID: 11860891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between folate, vitamin B12, total plasma homocysteine and mutation of reductase]. AU - Hao,L, AU - Liu,M, AU - Liu,X, AU - Chen,X, AU - Tang,Y, AU - Li,Z, PY - 2002/2/28/pubmed PY - 2004/10/13/medline PY - 2002/2/28/entrez SP - 22 EP - 4 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 34 IS - 1 N2 - OBJECTIVE: To study relationship between serum and red blood cell (RBC) folate, serum vitamin B(12) (VB(12)), total plasma homocysteine (tHcy), thermolabile genotypes, and activity of methylene-tetrahydrofolate reductase (MTHFR). METHODS: Thirty-four non-pregnant and healthy mothers who gave birth to babies with neural tube defects (NTDs) and 42 mothers to normal babies previously were chosen. Plasma tHcy, RBC and serum folate, serum VB(12), activity of MTHFR and thermolabile genotypes were determined for all of them. RESULTS: There was no significant difference in plasma tHcy, RBC and serun folate between case and control groups. Serum VB(12) was significantly lower in mothers of babies with NTDs than in those with normal ones. Plasma tHcy correlated with RBC folate inversely (P < 0.05). Mean plasma tHcy for thermolabile homozygous mutation of MTHFR was significantly higher than that for either heterozygous mutation or wild homozygous mutation (P < 0.001). There was no significant difference in serum folate between groups with varied MTHFR genotypes. Plasma tHcy was slightly greater in those with lower serum folate than in those with higher one, and correlated inversely with activity of MTHFR. CONCLUSIONS: Increase in plasma tHcy correlates with homozygous mutation of thermolabile MTHFR and decrease in activity of MTHFR. Higher level of folate in the body can interfere the relationship between plasma tHcy and activity of MTHFR. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/11860891/[Relationship_between_folate_vitamin_B12_total_plasma_homocysteine_and_mutation_of_reductase]_ L2 - https://medlineplus.gov/folicacid.html DB - PRIME DP - Unbound Medicine ER -