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A study of the effect of a single neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on the subsequent long-term behaviour of rats in the plus maze and open field.
Psychopharmacology (Berl) 2002; 159(2):167-75P

Abstract

RATIONALE

Decreased 5-HT function has been shown to induce behaviour consistent with an "anxiolytic" effect. Administration of a single dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy" 12.5 mg/kg IP) to rats results in prolonged damage to central serotonergic nerve terminals. Thus we wished to assess whether an MDMA-induced lesion may have longer-term behavioural consequences.

OBJECTIVE

The study was designed to examine the behaviour of MDMA-pretreated and control animals in the elevated plus-maze and open field at a number of time-points, up to 80 days, after the administration of a single neurotoxic dose of MDMA (12.5 mg/kg IP).

RESULTS

MDMA-pretreated Dark Agouti rats demonstrated a statistically significant reduction in anxiety-related behaviour, compared to saline-pretreated control rats, in both the elevated plus-maze and open field when the rats were tested on day 73 (open field) and day 80 (plus maze) after MDMA administration.

CONCLUSIONS

The behavioural consequences of a single neurotoxic dose of MDMA can be demonstrated over 2 months after administration of the compound, thereby indicating that long-term adaptive changes occur within the brain following the neurodegeneration of 5-HT neurones produced by this recreationally used drug.

Authors+Show Affiliations

Department of Pharmacology, School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11862345

Citation

Mechan, Annis O., et al. "A Study of the Effect of a Single Neurotoxic Dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") On the Subsequent Long-term Behaviour of Rats in the Plus Maze and Open Field." Psychopharmacology, vol. 159, no. 2, 2002, pp. 167-75.
Mechan AO, Moran PM, Elliott M, et al. A study of the effect of a single neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on the subsequent long-term behaviour of rats in the plus maze and open field. Psychopharmacology (Berl). 2002;159(2):167-75.
Mechan, A. O., Moran, P. M., Elliott, M., Young, A. J., Joseph, M. H., & Green, R. (2002). A study of the effect of a single neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on the subsequent long-term behaviour of rats in the plus maze and open field. Psychopharmacology, 159(2), pp. 167-75.
Mechan AO, et al. A Study of the Effect of a Single Neurotoxic Dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") On the Subsequent Long-term Behaviour of Rats in the Plus Maze and Open Field. Psychopharmacology (Berl). 2002;159(2):167-75. PubMed PMID: 11862345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of the effect of a single neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on the subsequent long-term behaviour of rats in the plus maze and open field. AU - Mechan,Annis O, AU - Moran,Paula M, AU - Elliott,MartinJ, AU - Young,Andrew J, AU - Joseph,Michael H, AU - Green,RichardA, Y1 - 2001/10/03/ PY - 2001/03/01/received PY - 2001/08/04/accepted PY - 2002/2/28/pubmed PY - 2002/4/3/medline PY - 2002/2/28/entrez SP - 167 EP - 75 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 159 IS - 2 N2 - RATIONALE: Decreased 5-HT function has been shown to induce behaviour consistent with an "anxiolytic" effect. Administration of a single dose of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy" 12.5 mg/kg IP) to rats results in prolonged damage to central serotonergic nerve terminals. Thus we wished to assess whether an MDMA-induced lesion may have longer-term behavioural consequences. OBJECTIVE: The study was designed to examine the behaviour of MDMA-pretreated and control animals in the elevated plus-maze and open field at a number of time-points, up to 80 days, after the administration of a single neurotoxic dose of MDMA (12.5 mg/kg IP). RESULTS: MDMA-pretreated Dark Agouti rats demonstrated a statistically significant reduction in anxiety-related behaviour, compared to saline-pretreated control rats, in both the elevated plus-maze and open field when the rats were tested on day 73 (open field) and day 80 (plus maze) after MDMA administration. CONCLUSIONS: The behavioural consequences of a single neurotoxic dose of MDMA can be demonstrated over 2 months after administration of the compound, thereby indicating that long-term adaptive changes occur within the brain following the neurodegeneration of 5-HT neurones produced by this recreationally used drug. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/11862345/A_study_of_the_effect_of_a_single_neurotoxic_dose_of_34_methylenedioxymethamphetamine__MDMA L2 - https://dx.doi.org/10.1007/s002130100900 DB - PRIME DP - Unbound Medicine ER -