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Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity.
Am J Clin Nutr. 2002 Mar; 75(3):484-91.AJ

Abstract

BACKGROUND

The fatty acid content and saturation degree of the diet can modulate HDL composition and cholesterol efflux.

OBJECTIVE

We studied the modifications in plasma lipoprotein particles and serum capacity to stimulate cholesterol efflux induced by different fatty acids.

DESIGN

Seventeen women and 24 men followed in the same sequence 4 diets containing 35% of total energy as fat. The saturated fat diet contained 17% palm oil; the monounsaturated fat diet, 20.9% olive oil; the n-6 polyunsaturated fat diet, 12.5% sunflower oil; and the n-3 polyunsaturated fat diet, sunflower oil supplemented with 4-4.5 g fish oil/d. Each phase lasted 4-5 wk.

RESULTS

In both sexes, apolipoprotein (apo) A-I concentrations were significantly lower with unsaturated fat diets than with the saturated fat diet, but concentrations of lipoproteins containing only apo A-I (Lp A-I) were lower only in the men. Concentrations of lipoproteins containing both apo A-I and apo A-II (Lp A-I:A-II) were lower with both polyunsaturated fat diets in the women but significantly higher in the men. Lp E concentrations were significantly higher with the 2 polyunsaturated fat diets. Lp E non-B particle concentrations were not modified in the men but were significantly higher in the women in both polyunsaturated fat phases. Lp C-III concentrations were higher with the saturated fat diet only in the men. The serum samples taken after the n-3 polyunsaturated fat phase were the most efficient for extracting cellular cholesterol in both sexes.

CONCLUSIONS

The monounsaturated and polyunsaturated fat diets were healthier, producing a better lipid profile. The n-3 polyunsaturated fat diet increased the capacity of serum to promote the efflux of cholesterol from cells in culture.

Authors+Show Affiliations

Fundación Jiménez Díaz, Servicio de Bioquímica Clínica, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11864853

Citation

Montoya, Maria Teresa, et al. "Fatty Acid Saturation of the Diet and Plasma Lipid Concentrations, Lipoprotein Particle Concentrations, and Cholesterol Efflux Capacity." The American Journal of Clinical Nutrition, vol. 75, no. 3, 2002, pp. 484-91.
Montoya MT, Porres A, Serrano S, et al. Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity. Am J Clin Nutr. 2002;75(3):484-91.
Montoya, M. T., Porres, A., Serrano, S., Fruchart, J. C., Mata, P., Gerique, J. A., & Castro, G. R. (2002). Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity. The American Journal of Clinical Nutrition, 75(3), 484-91.
Montoya MT, et al. Fatty Acid Saturation of the Diet and Plasma Lipid Concentrations, Lipoprotein Particle Concentrations, and Cholesterol Efflux Capacity. Am J Clin Nutr. 2002;75(3):484-91. PubMed PMID: 11864853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity. AU - Montoya,Maria Teresa, AU - Porres,Amelia, AU - Serrano,Sagrario, AU - Fruchart,Jean Charles, AU - Mata,Pedro, AU - Gerique,Juan Antonio Gómez, AU - Castro,Graciela Rosa, PY - 2002/2/28/pubmed PY - 2002/3/19/medline PY - 2002/2/28/entrez SP - 484 EP - 91 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 75 IS - 3 N2 - BACKGROUND: The fatty acid content and saturation degree of the diet can modulate HDL composition and cholesterol efflux. OBJECTIVE: We studied the modifications in plasma lipoprotein particles and serum capacity to stimulate cholesterol efflux induced by different fatty acids. DESIGN: Seventeen women and 24 men followed in the same sequence 4 diets containing 35% of total energy as fat. The saturated fat diet contained 17% palm oil; the monounsaturated fat diet, 20.9% olive oil; the n-6 polyunsaturated fat diet, 12.5% sunflower oil; and the n-3 polyunsaturated fat diet, sunflower oil supplemented with 4-4.5 g fish oil/d. Each phase lasted 4-5 wk. RESULTS: In both sexes, apolipoprotein (apo) A-I concentrations were significantly lower with unsaturated fat diets than with the saturated fat diet, but concentrations of lipoproteins containing only apo A-I (Lp A-I) were lower only in the men. Concentrations of lipoproteins containing both apo A-I and apo A-II (Lp A-I:A-II) were lower with both polyunsaturated fat diets in the women but significantly higher in the men. Lp E concentrations were significantly higher with the 2 polyunsaturated fat diets. Lp E non-B particle concentrations were not modified in the men but were significantly higher in the women in both polyunsaturated fat phases. Lp C-III concentrations were higher with the saturated fat diet only in the men. The serum samples taken after the n-3 polyunsaturated fat phase were the most efficient for extracting cellular cholesterol in both sexes. CONCLUSIONS: The monounsaturated and polyunsaturated fat diets were healthier, producing a better lipid profile. The n-3 polyunsaturated fat diet increased the capacity of serum to promote the efflux of cholesterol from cells in culture. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11864853/Fatty_acid_saturation_of_the_diet_and_plasma_lipid_concentrations_lipoprotein_particle_concentrations_and_cholesterol_efflux_capacity_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/75.3.484 DB - PRIME DP - Unbound Medicine ER -